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PROSITE entry PS50175


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PURL: https://purl.expasy.org/prosite/signature/PS50175

Direct ScanProsite submission
General information about the entry

Entry name [info] ASP_PROT_RETROV
Accession [info] PS50175
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED;
26-FEB-2020 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00128
Associated ProRule [info] PRU00275

Name and characterization of the entry

Description [info] Aspartyl protease, retroviral-type family profile.
Matrix / Profile [info] 
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=72;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=67;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-0.7856000; R2=0.0251893; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2336.9001465; R2=5.5017223; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=369; H_SCORE=4367; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=290; H_SCORE=3932; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105;

...
 
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='V';  M= -7,-21,-18,-26,-19,  9,-28,-22,  9,-11,  5,  4,-17,-22,-18,-10,-13, -3, 11,-17,  0,-19;
/M: SY='E';  M= -8,  1,-24,  2, 18,-21,-19, -7,-18,  9,-14,-10,  0,-11,  8,  7, -1,  0,-15,-27,-13, 13;
/M: SY='A';  M= 12,-18,-18,-24,-20,  3,  5,-20, -8,-19, -4, -3,-13,-20,-21,-20, -4, -8, -1,-15, -9,-19;
/M: SY='L';  M=-10,-30,-20,-31,-21,  9,-31,-21, 22,-30, 47, 20,-29,-29,-20,-21,-29,-10, 13,-20,  0,-21;
/M: SY='L';  M= -7,-30,-17,-31,-24,  9,-30,-23, 23,-27, 36, 16,-29,-30,-24,-20,-23, -7, 22,-22, -2,-24;
/M: SY='D';  M=-20, 50,-30, 70, 20,-40,-10,  0,-40,  0,-30,-30, 20,-10,  0,-10,  0,-10,-30,-40,-20, 10;
/M: SY='T';  M=  0,  0,-10,-10,-10,-10,-19,-20,-10,-10,-11,-10,  0,-10,-10,-10, 21, 49,  0,-30,-10,-10;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='A';  M= 50,-10,-10,-20,-10,-20,  0,-20,-10,-10,-10,-10,-10,-10,-10,-20, 10,  0,  0,-20,-20,-10;
/M: SY='D';  M=-18, 43,-30, 60, 24,-39,-12,  1,-38,  2,-28,-27, 17, -9,  6, -8,  0,-10,-30,-38,-19, 15;
/M: SY='D';  M=-12,  5,-26,  7,  0,-20,-20,  2,-10, -3,-10, -5,  2,-16, -3, -4, -7, -7, -8,-29, -8, -3;
/M: SY='T';  M=  3, -1,-10, -7, -7,-13,-14,-17,-12,-10,-16,-13,  2,-11, -7,-10, 26, 37, -1,-33,-13, -7;
/M: SY='V';  M= -5,-30,-14,-34,-30, -1,-34,-30, 37,-25, 13, 13,-25,-26,-26,-25,-14, -5, 39,-26, -6,-30;
/M: SY='L';  M= -9,-30,-22,-34,-25,  7,-34,-25, 32,-29, 33, 18,-26,-26,-22,-24,-24, -9, 22,-20,  0,-25;
/M: SY='E';  M=  0,  0,-22, -2,  7,-23,-14,-10,-21,  6,-22,-14,  2,  3,  2,  2,  7,  7,-16,-28,-17,  4;
/M: SY='E';  M=-10,  0,-28,  2, 14,-20,-14, -4,-20,  2,-15,-11, -1,-13, 10,  3, -3, -6,-20,-18, -8, 11;
/M: SY='H';  M= -4, -4,-24, -9, -3,-17,-18,  3, -9, -2,-12, -2,  2, -7, -2, -1, -3, -3,-10,-26, -9, -5;
/M: SY='D';  M=-14, 15,-28, 18,  6,-20,-14, 10,-22, -5,-17,-12, 11,-17,  2, -7, -4, -9,-23,-17, -5,  4;
/M: SY='W';  M=-11,-21,-30,-22,-20,  4, -9,-19, -8,-20, -1, -5,-19,-26,-18,-18,-19,-15,-11, 29,  6,-18;
/M: SY='P';  M= -7, -7,-31, -2,  2,-28,-14,-10,-21,  0,-27,-15, -6, 34,  1, -8, -1, -6,-23,-29,-21, -1;
/I:         I=-7; MI=-5; IM=-5; DM=-15; MD=-15;
/M: SY='G';  M= -2, -8,-24, -8,-10,-21, 15,-16,-23, -5,-17,-12, -4,-15,-10, -4, -1, -6,-15,-24,-19,-10;
/M: SY='N';  M= -6, 11,-23,  6, -1,-22, -7, -5,-19,  2,-23,-15, 18, -9, -2,  2,  6,  0,-19,-32,-17, -3;
/M: SY='W';  M=-16,-23,-37,-24,-20,  3,-21,-16,-12,-13,-15,-13,-22,-16,-14,-13,-22,-15,-18, 63, 21,-16;
/M: SY='P';  M= -9,-10,-31, -7,  3,-27,-19,-11,-23, 13,-25,-13, -7, 24,  4, 12, -5, -5,-22,-25,-18,  1;
/M: SY='P';  M= -6,-16,-26,-17,-13,-15, -8,-20, -5,-11, -7, -5,-12,  2,-13,-12, -6, -1, -5,-24,-15,-15;
/M: SY='R';  M= -7, -5,-23, -8,  0,-20,-20, -2,-15, 11,-15, -4, -3,-14,  5, 12, -1,  3,-10,-24, -8,  1;
/I:         MD=-23;
/M: SY='B';  M= -7,  5,-19,  3,  4,-15,-12, -4, -8,  1,-12, -6,  5,  1,  2, -3, -2, -3,-11,-20,-10,  2; D=-4;
/I:         MD=-23;
/M: SY='A';  M=  7, -5, -9, -9, -7, -7, -5,-10, -4, -4, -6, -4, -4, -8, -6, -7,  3,  6,  0,-12, -4, -7; D=-4;
/I:         I=-4; MI=0; IM=0; DM=-23;
/M: SY='M';  M= -4, -8,-23,-14,-12,-14,-12,-10, -1, -7, -8,  1, -2,-18, -6, -9, -3, -4, -3,-20, -9, -9;
/M: SY='I';  M= -8,-26,-21,-29,-19,  0,-31,-22, 26,-23, 24, 16,-24,-24,-16,-20,-19, -8, 21,-23, -4,-19;
/M: SY='Q';  M= -8,-11,-28,-13, -6,-24,  4, -5,-13, -9,-11, -2, -6,-18,  9, -5, -7,-13,-15,-21,-13,  0;
/M: SY='G';  M=  5,-10,-28,-11,-19,-29, 63,-20,-37,-19,-28,-19, -1,-19,-19,-20,  1,-18,-27,-20,-29,-19;
/M: SY='I';  M=  2,-24,-22,-31,-24, -4,-29,-26, 29,-24, 12, 11,-18,-19,-18,-24,-10, -3, 23,-23, -6,-24;
/M: SY='G';  M=  0, -7,-28, -9,-18,-28, 60,-19,-37,-18,-29,-19,  3,-19,-18,-18,  2,-14,-28,-22,-28,-18;
/M: SY='G';  M= -2, -8,-28, -9,-13,-27, 42,-13,-31,-14,-25,-13, -1,-18, -6,-14,  1,-13,-25,-20,-20, -9;
/M:         M=  0,-10,-21,-16,-13, -6, -4,-15, -8,-10,-11, -6, -4,-18,-10, -9,  0, -2, -4,-21,-10,-11;
/M: SY='I';  M= -5,-10,-15,-16,-14,-10,-23,-18,  7,-10, -3,  0, -3,-19,-12,-12, -2,  3,  7,-29,-10,-14;
/M: SY='N';  M=-11,  4,-20,  1,  7,-19,-13,  0,-20,  5,-19,-10,  8,-11,  3,  7, -2, -5,-19,-27,-11,  4;
/M:         M= -3,-11,-23,-12,-12,-16, -8,-12, -7,-12,-12, -5,-10,  0,-11,-15, -4, -3, -2,-26,-13,-13;
/M: SY='R';  M=-11, -7,-28, -7,  5,-11,-21, -4,-23, 16,-18,-10, -5,-15,  4, 18, -8, -6,-18, -9, -1,  4;
/M: SY='Q';  M=-11, -5,-29, -6,  7,-18,-20, -4,-19, 11,-19, -8, -3,-14, 15, 10, -5, -7,-20, -6, -2, 11;
/M: SY='Y';  M= -7, -9,-22,-12,-10,  0,-17, -6,-12, -6,-13,-10, -5,-19, -7, -7,  3,  7,-11,  2, 14, -9;
/M: SY='D';  M= -7,  3,-24,  4,  0,-19,-15,-10,-16, -2,-15,-10,  2,-10, -2, -4,  1,  0,-14,-21,-12, -1;
/M: SY='N';  M=-10,  9,-24,  8,  7,-24,-13,  3,-19,  3,-18,-10, 11,-16, 10,  5,  0, -5,-18,-29,-13,  7;
/M: SY='V';  M= -4,-20,-18,-23,-17, -6,-25,-18, 11,-12,  4,  8,-18,-18,-12, -8, -7,  1, 17,-24, -7,-16;
/M: SY='L';  M=-10,-15,-26,-14, -1, -9,-21, -2, -2,-13,  7,  2,-14,-12, -5,-10,-14, -9, -7,-23, -4, -5;
/M: SY='V';  M= -8,-18,-24,-19,-11, -9,-26,-15,  2, -7,  1,  1,-17,-10,-12, -8,-12, -3,  4,-16, -6,-12;
/M: SY='W';  M=-12,-12,-25,-12,  2,-16,-22, -6,-14, -1,-13, -7,-11,-18,  5,  0,-13,-13,-15,  6, -3,  3;
/M: SY='L';  M=-10,-18,-25,-20,-12, -1,-19,-14,  4,-12,  7,  4,-15,-21,-10,-11,-14, -7,  0,-15,  3,-12;
/M:         M= -8, -4,-22, -2,  0,-16, -9, -2,-19, -1,-13, -8, -4,-17, -5, -1, -7,-10,-13,-24,-10, -3;
/M: SY='D';  M= -7,  6,-26,  9,  5,-26, -6, -9,-23,  3,-20,-14,  3, -9,  0,  0,  0, -6,-19,-28,-17,  2;
/M: SY='E';  M=-11,  5,-29,  9, 14,-26,-11,  1,-26, 11,-19,-12,  2, -7,  7,  4, -6,-11,-23,-27,-13,  9;
/I:         I=-5; MI=0; MD=-25; IM=0;
/M:         M= -5,-11,-21,-15,-14, -7, -1,-16, -9, -7,-12, -5, -4,-19,-13, -5, -1, -2, -3,-21,-10,-14; D=-5;
/I:         DM=-25;
/M: SY='T';  M= -7,-15,-23,-19,-13, -9,-21,-12,  1, -9,  0,  1,-11,-13, -8, -4, -7,  3,  1,-21, -4,-13;
/M: SY='R';  M=-12,-11,-26,-13, -2, -6,-25,  1, -7,  1, -8, -2, -7,-17, -4,  5, -9, -6, -5,-21, -1, -4;
/M: SY='G';  M=  0, -7,-22,-10,-10,-21, 10,-11,-19, -8,-20,-11,  0,-15, -6, -7,  8,  3,-13,-26,-16, -9;
/M: SY='P';  M= -9,-10,-27, -9, -5,-10,-20,-16,-16, -9,-18,-14,-10, 29, -9,-11, -1,  7,-17,-24,-14, -9;
/M: SY='I';  M=-10,-28,-15,-32,-26, 14,-31,-19, 22,-24, 18, 15,-24,-27,-22,-21,-19, -8, 19,-14,  9,-25;
/M: SY='I';  M= -7,-29,-19,-32,-26,  4,-32,-24, 30,-25, 24, 17,-27,-27,-23,-22,-19, -6, 29,-22, -1,-26;
/M: SY='I';  M= -7,-26,-18,-31,-25,  9,-31,-25, 24,-24, 20, 11,-23,-25,-23,-21,-14,  1, 23,-21, -1,-25;
/M: SY='P';  M= -2,-15,-27,-14,-11,-16,  3,-19,-15,-17,-15,-12,-10, 16,-14,-19, -1, -5,-16,-25,-20,-14;
/I:         MD=-18;
/M: SY='P';  M= -4,  6,-24, 10,  9,-23,-11, -7,-21, -4,-23,-18,  5, 16, -1,-10,  5, -1,-21,-29,-17,  3; D=-4;
/I:         I=-4; MI=0; IM=0; DM=-18;
/M: SY='T';  M= -6, -7,  2,-13,-14, -9,-21,-18, -2,-18,  1, -4, -5,-21,-14,-16, -1,  9,  1,-32,-12,-15;
/M: SY='P';  M=-11,-15,-37, -9,  0,-28,-20,-17,-18, -2,-27,-17,-14, 64, -7,-10,-10,-10,-26,-28,-25, -8;
/M: SY='V';  M= -5,-27,-23,-30,-25,  3,-23,-22, 13,-20,  3,  3,-25,-26,-20,-19,-16, -9, 16,  6,  5,-22;
/M: SY='N';  M= -5, 15,-23,  8,  6,-23,-10, -3,-20, -3,-25,-17, 21,  5,  2, -6,  7,  4,-24,-34,-20,  3;
/M: SY='I';  M= -9,-30,-23,-34,-25,  5,-34,-25, 34,-29, 33, 19,-26,-26,-21,-24,-24, -9, 23,-21, -1,-25;
/M: SY='L';  M=-13,-32,-29,-36,-26, 14,-30,-25, 16,-28, 23,  9,-29,-28,-22,-22,-29,-15,  5, 21, 10,-23;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='R';  M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='D';  M=-16, 45,-27, 56, 15,-35, -8,  1,-35, -1,-30,-28, 27,-12,  0, -8,  4, -6,-29,-40,-20,  8;
/M: SY='I';  M= -4,-17,-15,-25,-21, -1,-26,-20, 19,-23, 16,  8,-11,-24,-18,-21,-15, -7, 11,-24, -6,-21;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 160 in 160 different sequences
Number of true positive hits 153 in 153 different sequences
Number of 'unknown' hits 0
Number of false positive hits 7 in 7 different sequences
Number of false negative sequences 17
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 95.62 %
Recall (true positives / (true positives + false negatives)) 90.00 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] DOMAIN
Feature description [info] Peptidase A2
Version [info] 6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 153 sequences 

APRV1_HUMAN (Q53RT3), APRV1_MOUSE (Q09PK2), DDI1_ARATH  (Q1EBV4), 

GAG_ALVA(P0C776), GAG_AVIMA   (P26315), GAG_IPHA(P04023), 
GAG_IPMA(P11365), GAG_RSVP(P03322), GAG_RSVSB   (O92954), 
POK9_HUMAN  (P63128), POL4_DROME  (P10394), POL_ALV (Q7SQ98), 
POL_ALVA(Q04095), POL_AVIRE   (P03360), POL_BAEVM   (P10272), 
POL_BIV29   (P19560), POL_BLVAU   (P25059), POL_BLVJ(P03361), 
POL_CAEVC   (P33459), POL_COYMV   (P19199), POL_EIAV9   (P11204), 
POL_EIAVC   (P32542), POL_EIAVY   (P03371), POL_FIVPE   (P16088), 
POL_FIVSD   (P19028), POL_FIVT2   (P31822), POL_FLV (P10273), 
POL_GALV(P21414), POL_HTL1A   (P03362), POL_HTL1C   (P14078), 
POL_HTL1L   (P0C211), POL_HTL32   (Q0R5R2), POL_HTL3P   (Q4U0X6), 
POL_HTLV2   (P03363), POL_HV190   (O93215), POL_HV192   (O12158), 
POL_HV193   (O89290), POL_HV196   (Q9QBY3), POL_HV197   (Q9QBZ9), 
POL_HV19N   (O41798), POL_HV1A2   (P03369), POL_HV1AN   (Q77373), 
POL_HV1B1   (P03366), POL_HV1B5   (P04587), POL_HV1B9   (Q73368), 
POL_HV1BR   (P03367), POL_HV1C4   (P05960), POL_HV1EL   (P04589), 
POL_HV1ET   (Q75002), POL_HV1H2   (P04585), POL_HV1J3   (P12498), 
POL_HV1JR   (P20875), POL_HV1LW   (P0C6F2), POL_HV1M2   (Q9QBZ1), 
POL_HV1MA   (P04588), POL_HV1MN   (P05961), POL_HV1MP   (Q9QBZ5), 
POL_HV1MV   (Q79666), POL_HV1N5   (P12497), POL_HV1ND   (P18802), 
POL_HV1OY   (P20892), POL_HV1RH   (P05959), POL_HV1S2   (Q9WC54), 
POL_HV1S9   (Q9WC63), POL_HV1SE   (O89940), POL_HV1U4   (P24740), 
POL_HV1V9   (Q9Q720), POL_HV1VI   (Q9QSR3), POL_HV1Y2   (P35963), 
POL_HV1YB   (Q9IDV9), POL_HV1YF   (O91080), POL_HV1Z2   (P12499), 
POL_HV2BE   (P18096), POL_HV2CA   (P24107), POL_HV2D1   (P17757), 
POL_HV2D2   (P15833), POL_HV2EH   (Q89928), POL_HV2G1   (P18042), 
POL_HV2KR   (Q74120), POL_HV2NZ   (P05962), POL_HV2RO   (P04584), 
POL_HV2SB   (P12451), POL_HV2ST   (P20876), POL_HV2UC   (Q76634), 
POL_JEMBR   (Q82851), POL_JSRV(P31623), POL_KORV(Q9TTC1), 
POL_MLVAV   (P03356), POL_MLVBM   (Q7SVK7), POL_MLVCB   (P08361), 
POL_MLVF5   (P26810), POL_MLVFF   (P26809), POL_MLVFP   (P26808), 
POL_MLVMS   (P03355), POL_MLVRD   (P11227), POL_MMTVB   (P03365), 
POL_MMTVC   (P11283), POL_MPMV(P07572), POL_OMVVS   (P16901), 
POL_RSVP(P03354), POL_RSVSB   (O92956), POL_SIVCZ   (P17283), 
POL_SIVEK   (Q1A249), POL_SIVG1   (Q02836), POL_SIVGB   (P22382), 
POL_SIVM1   (P05896), POL_SIVM2   (P05897), POL_SIVMB   (Q1A267), 
POL_SIVS4   (P12502), POL_SIVSP   (P19505), POL_SIVTN   (Q8AII1), 
POL_SIVV1   (P27973), POL_SIVVG   (P27980), POL_SIVVT   (P05895), 
POL_SMRVH   (P03364), POL_SRV1(P04025), POL_SRV2(P51517), 
POL_VILV(P03370), POL_VILV1   (P23426), POL_VILV2   (P23427), 
POL_VILVK   (P35956), POL_WMSV(P03359), POL_XMRV3   (Q2F7J3), 
POL_XMRV4   (Q2F7J0), POL_XMRV6   (A1Z651), PRO_BLVAU   (P0DOI1), 
PRO_BLVJ(P0DOI0), PRO_HTL1A   (P10274), PRO_HTL1C   (P14074), 
PRO_HTL1L   (P0C210), PRO_HTL32   (Q0R5R3), PRO_HTL3P   (Q09SZ9), 
PRO_HTLV2   (P03353), PRO_JSRV(P31625), PRO_MMTVB   (P10271), 
PRO_MMTVC   (Q9IZT2), PRO_MPMV(P07570), PRO_SMRVH   (P21407), 
PRO_SRV1(P04024), PRO_SRV2(P51518), VP113_HUMAN (P63121), 
VPK04_HUMAN (P63124), VPK10_HUMAN (P10265), VPK18_HUMAN (P63123), 
VPK19_HUMAN (P63120), VPK21_HUMAN (P63119), VPK24_HUMAN (P63129), 
VPK25_HUMAN (P63125), VPK6_HUMAN  (Q9Y6I0), VPK7_HUMAN  (P63131), 
VPK8_HUMAN  (P63122), VPK9_HUMAN  (P63127), VPRT_BLVJ   (P10270)
» more

UniProtKB/Swiss-Prot
False negative sequences		 17 sequences 

POL_CSVMV   (Q89703), POL_FFV (O93209), POL_FOAMV   (P14350), 

POL_SFV1(P23074), POL_SFV3L   (P27401), POL_WDSV(O92815), 
TF211_SCHPO (Q9UR07), TF212_SCHPO (P0CT41), TF21_SCHPO  (P0CT34), 
TF22_SCHPO  (P0CT35), TF23_SCHPO  (P0CT36), TF24_SCHPO  (P0CT37), 
TF25_SCHPO  (P0CT38), TF26_SCHPO  (P0CT39), TF27_SCHPO  (P0CT42), 
TF28_SCHPO  (P0CT43), TF29_SCHPO  (P0CT40)
» more

UniProtKB/Swiss-Prot
False positive sequences		 7 sequences 

DDI1_CANGA  (Q6FQE9), DDI1_CHAGB  (Q2H085), DDI1_EREGS  (Q754R2), 

DDI1_YARLI  (Q6CFI3), DDI1_YEAST  (P40087), NUC2_NEUCR  (Q01317), 
V219_FOWPN  (Q9J516)
» more

PDB
[Detailed view]		 777 PDB

pdb_00001a30; pdb_00001a8g; pdb_00001a8k; pdb_00001a94; pdb_00001a9m; pdb_00001aaq; pdb_00001aid; pdb_00001ajv; pdb_00001ajx; pdb_00001axa; pdb_00001az5; pdb_00001b11; pdb_00001b6j; pdb_00001b6k; pdb_00001b6l; pdb_00001b6m; pdb_00001b6p; pdb_00001bai; pdb_00001bdl; pdb_00001bdq; pdb_00001bdr; pdb_00001bv7; pdb_00001bv9; pdb_00001bve; pdb_00001bvg; pdb_00001bwa; pdb_00001bwb; pdb_00001cpi; pdb_00001d4h; pdb_00001d4i; pdb_00001d4j; pdb_00001d4k; pdb_00001d4l; pdb_00001d4s; pdb_00001d4y; pdb_00001daz; pdb_00001dif; pdb_00001dmp; pdb_00001dw6; pdb_00001ebk; pdb_00001ebw; pdb_00001eby; pdb_00001ebz; pdb_00001ec0; pdb_00001ec1; pdb_00001ec2; pdb_00001ec3; pdb_00001f7a; pdb_00001fb7; pdb_00001fej; pdb_00001ff0; pdb_00001fff; pdb_00001ffi; pdb_00001fg6; pdb_00001fg8; pdb_00001fgc; pdb_00001fiv; pdb_00001fmb; pdb_00001fqx; pdb_00001g2k; pdb_00001g35; pdb_00001g6l; pdb_00001gnm; pdb_00001gnn; pdb_00001gno; pdb_00001hbv; pdb_00001hef; pdb_00001heg; pdb_00001hhp; pdb_00001hih; pdb_00001hii; pdb_00001hiv; pdb_00001hos; pdb_00001hpo; pdb_00001hps; pdb_00001hpv; pdb_00001hpx; pdb_00001hsg; pdb_00001hsh; pdb_00001hsi; pdb_00001hte; pdb_00001htf; pdb_00001htg; pdb_00001hvh; pdb_00001hvi; pdb_00001hvj; pdb_00001hvk; pdb_00001hvl; pdb_00001hvr; pdb_00001hvs; pdb_00001hwr; pdb_00001hxb; pdb_00001hxw; pdb_00001ida; pdb_00001idb; pdb_00001iiq; pdb_00001ivp; pdb_00001ivq; pdb_00001izi; pdb_00001jld; pdb_00001k1t; pdb_00001k1u; pdb_00001k2b; pdb_00001k2c; pdb_00001k6c; pdb_00001k6p; pdb_00001k6t; pdb_00001k6v; pdb_00001kj4; pdb_00001kj7; pdb_00001kjf; pdb_00001kjg; pdb_00001kjh; pdb_00001kzk; pdb_00001lv1; pdb_00001lzq; pdb_00001m0b; pdb_00001mer; pdb_00001mes; pdb_00001met; pdb_00001meu; pdb_00001mrw; pdb_00001mrx; pdb_00001msm; pdb_00001msn; pdb_00001mt7; pdb_00001mt8; pdb_00001mt9; pdb_00001mtb; pdb_00001mtr; pdb_00001mvp; pdb_00001n49; pdb_00001nh0; pdb_00001npa; pdb_00001npv; pdb_00001npw; pdb_00001nso; pdb_00001odw; pdb_00001odx; pdb_00001ody; pdb_00001pro; pdb_00001q9p; pdb_00001qbr; pdb_00001qbs; pdb_00001qbt; pdb_00001qbu; pdb_00001rl8; pdb_00001sbg; pdb_00001sdt; pdb_00001sdu; pdb_00001sdv; pdb_00001sgu; pdb_00001sh9; pdb_00001siv; pdb_00001sp5; pdb_00001t3r; pdb_00001t7i; pdb_00001t7j; pdb_00001t7k; pdb_00001tcw; pdb_00001tcx; pdb_00001tsq; pdb_00001tsu; pdb_00001u8g; pdb_00001upj; pdb_00001vij; pdb_00001vik; pdb_00001w5v; pdb_00001w5w; pdb_00001w5x; pdb_00001w5y; pdb_00001xl2; pdb_00001xl5; pdb_00001yt9; pdb_00001ytg; pdb_00001yth; pdb_00001yti; pdb_00001ytj; pdb_00001z1h; pdb_00001z1r; pdb_00001z8c; pdb_00001zbg; pdb_00001zj7; pdb_00001zlf; pdb_00001zp8; pdb_00001zpa; pdb_00001zpk; pdb_00001zsf; pdb_00001zsr; pdb_00001ztz; pdb_00002a1e; pdb_00002aid; pdb_00002aoc; pdb_00002aod; pdb_00002aoe; pdb_00002aof; pdb_00002aog; pdb_00002aoh; pdb_00002aoi; pdb_00002aoj; pdb_00002aqu; pdb_00002avm; pdb_00002avo; pdb_00002avq; pdb_00002avs; pdb_00002avv; pdb_00002az8; pdb_00002az9; pdb_00002azb; pdb_00002azc; pdb_00002b7f; pdb_00002b7z; pdb_00002bb9; pdb_00002bbb; pdb_00002bpv; pdb_00002bpw; pdb_00002bpx; pdb_00002bpy; pdb_00002bpz; pdb_00002f3k; pdb_00002f80; pdb_00002f81; pdb_00002f8g; pdb_00002fde; pdb_00002fgu; pdb_00002fgv; pdb_00002fiv; pdb_00002fmb; pdb_00002fns; pdb_00002fnt; pdb_00002fxe; pdb_00002g69; pdb_00002hah; pdb_00002hb2; pdb_00002hb3; pdb_00002hb4; pdb_00002hc0; pdb_00002hpe; pdb_00002hpf; pdb_00002hs1; pdb_00002hs2; pdb_00002hvp; pdb_00002i4d; pdb_00002i4u; pdb_00002i4v; pdb_00002i4w; pdb_00002i4x; pdb_00002idw; pdb_00002ien; pdb_00002ieo; pdb_00002j9j; pdb_00002j9k; pdb_00002je4; pdb_00002mip; pdb_00002nmy; pdb_00002nmz; pdb_00002nnk; pdb_00002nnp; pdb_00002nph; pdb_00002nxd; pdb_00002nxl; pdb_00002nxm; pdb_00002o4k; pdb_00002o4l; pdb_00002o4n; pdb_00002o4p; pdb_00002o4s; pdb_00002p3b; pdb_00002pk5; pdb_00002pk6; pdb_00002pqz; pdb_00002pwc; pdb_00002pwr; pdb_00002pym; pdb_00002pyn; pdb_00002q3k; pdb_00002q63; pdb_00002q64; pdb_00002qak; pdb_00002qci; pdb_00002qd6; pdb_00002qd7; pdb_00002qd8; pdb_00002qhc; pdb_00002qhy; pdb_00002qhz; pdb_00002qi0; pdb_00002qi1; pdb_00002qi3; pdb_00002qi4; pdb_00002qi5; pdb_00002qi6; pdb_00002qi7; pdb_00002qnn; pdb_00002qnp; pdb_00002qnq; pdb_00002r38; pdb_00002r3t; pdb_00002r3w; pdb_00002r43; pdb_00002r5p; pdb_00002r5q; pdb_00002r8n; pdb_00002rsp; pdb_00002upj; pdb_00002uxz; pdb_00002uy0; pdb_00002whh; pdb_00002wkz; pdb_00002wl0; pdb_00002xye; pdb_00002xyf; pdb_00002z4o; pdb_00002z54; pdb_00002zga; pdb_00002zye; pdb_00003a2o; pdb_00003aid; pdb_00003b7v; pdb_00003b80; pdb_00003bc4; pdb_00003bgb; pdb_00003bgc; pdb_00003bhe; pdb_00003bva; pdb_00003bvb; pdb_00003bxr; pdb_00003bxs; pdb_00003ckt; pdb_00003cyw; pdb_00003cyx; pdb_00003d1x; pdb_00003d1y; pdb_00003d1z; pdb_00003d20; pdb_00003djk; pdb_00003dk1; pdb_00003dox; pdb_00003ebz; pdb_00003ec0; pdb_00003ecg; pdb_00003ekp; pdb_00003ekq; pdb_00003ekt; pdb_00003ekv; pdb_00003ekw; pdb_00003ekx; pdb_00003eky; pdb_00003el0; pdb_00003el1; pdb_00003el4; pdb_00003el5; pdb_00003el9; pdb_00003em3; pdb_00003em4; pdb_00003em6; pdb_00003fiv; pdb_00003fsm; pdb_00003fx5; pdb_00003gga; pdb_00003ggu; pdb_00003ggv; pdb_00003ggx; pdb_00003gi0; pdb_00003gi4; pdb_00003gi5; pdb_00003gi6; pdb_00003h5b; pdb_00003hau; pdb_00003haw; pdb_00003hbo; pdb_00003hdk; pdb_00003hlo; pdb_00003hvp; pdb_00003hzc; pdb_00003i2l; pdb_00003i6o; pdb_00003i7e; pdb_00003i8w; pdb_00003iaw; pdb_00003ixo; pdb_00003jvw; pdb_00003jvy; pdb_00003jw2; pdb_00003k4v; pdb_00003ka2; pdb_00003kdb; pdb_00003kdc; pdb_00003kdd; pdb_00003kf0; pdb_00003kfn; pdb_00003kfp; pdb_00003kfr; pdb_00003kfs; pdb_00003kt2; pdb_00003kt5; pdb_00003lzs; pdb_00003lzu; pdb_00003lzv; pdb_00003mxd; pdb_00003mxe; pdb_00003n3i; pdb_00003ndt; pdb_00003ndu; pdb_00003ndw; pdb_00003ndx; pdb_00003nls; pdb_00003nr6; pdb_00003nu3; pdb_00003nu4; pdb_00003nu5; pdb_00003nu6; pdb_00003nu9; pdb_00003nuj; pdb_00003nuo; pdb_00003nwq; pdb_00003nwx; pdb_00003nxn; pdb_00003nyg; pdb_00003o9f; pdb_00003o9g; pdb_00003o9h; pdb_00003o9i; pdb_00003ogp; pdb_00003ogq; pdb_00003ok9; pdb_00003oq7; pdb_00003oqa; pdb_00003oqd; pdb_00003ots; pdb_00003oty; pdb_00003ou1; pdb_00003ou3; pdb_00003ou4; pdb_00003oua; pdb_00003oub; pdb_00003ouc; pdb_00003oud; pdb_00003oxc; pdb_00003oxv; pdb_00003oxw; pdb_00003oxx; pdb_00003oy4; pdb_00003phv; pdb_00003pj6; pdb_00003psu; pdb_00003pwm; pdb_00003pwr; pdb_00003qaa; pdb_00003qbf; pdb_00003qih; pdb_00003qn8; pdb_00003qp0; pdb_00003qpj; pdb_00003qrm; pdb_00003qro; pdb_00003qrs; pdb_00003r4b; pdb_00003s85; pdb_00003sqf; pdb_00003st5; pdb_00003t11; pdb_00003t3c; pdb_00003th9; pdb_00003tkg; pdb_00003tkw; pdb_00003tl9; pdb_00003tlh; pdb_00003tof; pdb_00003tog; pdb_00003toh; pdb_00003ttp; pdb_00003u7s; pdb_00003ucb; pdb_00003uf3; pdb_00003ufn; pdb_00003uhl; pdb_00003upj; pdb_00003vf5; pdb_00003vf7; pdb_00003vfa; pdb_00003vfb; pdb_00003zps; pdb_00003zpt; pdb_00003zpu; pdb_00004a6b; pdb_00004a6c; pdb_00004coe; pdb_00004cp7; pdb_00004cpq; pdb_00004cpr; pdb_00004cps; pdb_00004cpt; pdb_00004cpu; pdb_00004cpw; pdb_00004cpx; pdb_00004dfg; pdb_00004dqb; pdb_00004dqc; pdb_00004dqe; pdb_00004dqf; pdb_00004dqg; pdb_00004dqh; pdb_00004e43; pdb_00004ej8; pdb_00004ejd; pdb_00004ejk; pdb_00004ejl; pdb_00004ep2; pdb_00004ep3; pdb_00004epj; pdb_00004eq0; pdb_00004eqj; pdb_00004f73; pdb_00004f74; pdb_00004f75; pdb_00004f76; pdb_00004faf; pdb_00004fe6; pdb_00004fiv; pdb_00004fl8; pdb_00004flg; pdb_00004fm6; pdb_00004gb2; pdb_00004hdb; pdb_00004hdf; pdb_00004hdp; pdb_00004he9; pdb_00004heg; pdb_00004hla; pdb_00004hvp; pdb_00004i8w; pdb_00004i8z; pdb_00004j54; pdb_00004j55; pdb_00004j5j; pdb_00004jec; pdb_00004k4p; pdb_00004k4q; pdb_00004k4r; pdb_00004ll3; pdb_00004mc1; pdb_00004mc2; pdb_00004mc6; pdb_00004mc9; pdb_00004obd; pdb_00004obf; pdb_00004obg; pdb_00004obh; pdb_00004obj; pdb_00004obk; pdb_00004phv; pdb_00004q1w; pdb_00004q1x; pdb_00004q1y; pdb_00004q5m; pdb_00004qgi; pdb_00004qj2; pdb_00004qj6; pdb_00004qj7; pdb_00004qj8; pdb_00004qj9; pdb_00004qja; pdb_00004qlh; pdb_00004u7q; pdb_00004u7v; pdb_00004u8w; pdb_00004upj; pdb_00004ydg; pdb_00004ye3; pdb_00004yhq; pdb_00004zip; pdb_00004zls; pdb_00005agz; pdb_00005ah6; pdb_00005ah7; pdb_00005ah8; pdb_00005ah9; pdb_00005aha; pdb_00005ahb; pdb_00005ahc; pdb_00005bry; pdb_00005bs4; pdb_00005dgu; pdb_00005dgw; pdb_00005e5k; pdb_00005fiv; pdb_00005hvp; pdb_00005jfp; pdb_00005jfu; pdb_00005jg1; pdb_00005kao; pdb_00005ufz; pdb_00005ult; pdb_00005uov; pdb_00005upj; pdb_00005upz; pdb_00005vck; pdb_00005vea; pdb_00005vj3; pdb_00005w5w; pdb_00005yoj; pdb_00005yok; pdb_00005yrs; pdb_00006b36; pdb_00006b38; pdb_00006b3c; pdb_00006b3f; pdb_00006b3g; pdb_00006b3h; pdb_00006bz2; pdb_00006c8x; pdb_00006c8y; pdb_00006d0d; pdb_00006d0e; pdb_00006dif; pdb_00006dil; pdb_00006dj1; pdb_00006dj2; pdb_00006dj5; pdb_00006dj7; pdb_00006dv0; pdb_00006dv4; pdb_00006e7j; pdb_00006e9a; pdb_00006fiv; pdb_00006kmp; pdb_00006mcr; pdb_00006mcs; pdb_00006o48; pdb_00006oos; pdb_00006oot; pdb_00006oou; pdb_00006opw; pdb_00006opy; pdb_00006opz; pdb_00006oxo; pdb_00006oxp; pdb_00006oxq; pdb_00006oxr; pdb_00006oxs; pdb_00006oxt; pdb_00006oxu; pdb_00006oxv; pdb_00006oxw; pdb_00006oxx; pdb_00006oxy; pdb_00006oxz; pdb_00006oy0; pdb_00006oy1; pdb_00006oy2; pdb_00006oyd; pdb_00006oyr; pdb_00006p9a; pdb_00006p9b; pdb_00006pjb; pdb_00006pjc; pdb_00006pjd; pdb_00006pje; pdb_00006pjf; pdb_00006pjg; pdb_00006pjh; pdb_00006pji; pdb_00006pjk; pdb_00006pjl; pdb_00006pjm; pdb_00006pjn; pdb_00006pjo; pdb_00006prf; pdb_00006s1u; pdb_00006s1v; pdb_00006s1w; pdb_00006upj; pdb_00006uwb; pdb_00006uwc; pdb_00006vce; pdb_00006vod; pdb_00006voe; pdb_00006w6q; pdb_00006w6r; pdb_00006w6s; pdb_00006w6t; pdb_00007bgt; pdb_00007bgu; pdb_00007doz; pdb_00007dpq; pdb_00007dt9; pdb_00007hvp; pdb_00007ldy; pdb_00007ldz; pdb_00007le0; pdb_00007le1; pdb_00007le2; pdb_00007le3; pdb_00007le4; pdb_00007le5; pdb_00007le6; pdb_00007le7; pdb_00007le8; pdb_00007le9; pdb_00007lea; pdb_00007leb; pdb_00007lec; pdb_00007led; pdb_00007lee; pdb_00007lef; pdb_00007leg; pdb_00007leh; pdb_00007lei; pdb_00007m9g; pdb_00007m9h; pdb_00007m9i; pdb_00007m9j; pdb_00007m9k; pdb_00007m9l; pdb_00007m9m; pdb_00007m9n; pdb_00007m9o; pdb_00007m9p; pdb_00007m9q; pdb_00007m9r; pdb_00007m9s; pdb_00007m9t; pdb_00007m9u; pdb_00007m9v; pdb_00007m9w; pdb_00007m9x; pdb_00007m9z; pdb_00007ma0; pdb_00007ma1; pdb_00007ma2; pdb_00007ma3; pdb_00007ma4; pdb_00007ma5; pdb_00007ma6; pdb_00007ma7; pdb_00007ma8; pdb_00007ma9; pdb_00007maa; pdb_00007mab; pdb_00007mac; pdb_00007mad; pdb_00007mae; pdb_00007maf; pdb_00007mag; pdb_00007mah; pdb_00007mai; pdb_00007maj; pdb_00007mak; pdb_00007mal; pdb_00007man; pdb_00007mao; pdb_00007map; pdb_00007maq; pdb_00007mar; pdb_00007mas; pdb_00007n6t; pdb_00007n6v; pdb_00007n6x; pdb_00007sep; pdb_00007sjx; pdb_00007to5; pdb_00007to6; pdb_00007upj; pdb_00007wbs; pdb_00007wcq; pdb_00007yf6; pdb_00008dch; pdb_00008dci; pdb_00008esx; pdb_00008esy; pdb_00008f0f; pdb_00008fui; pdb_00008fuj; pdb_00008hvp; pdb_00008vb1; pdb_00009hvp
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