ProRule PRU00280
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00280 |
| Accession | PRU00280 |
| Dates | 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 12) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50846; HMA_2 |
Name | Heavy-metal-associated domain |
| Function | Found in proteins that transport or detoxify heavy metals. This domain contains two conserved cysteines that could be involved in the binding of these metals. |
| Scope(s) |
Eukaryota Bacteria |
| Example(s) | Q47840 (COPZ_ENTHA); |
Propagated annotation
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Keywords
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| Metal-binding | |
| end case | |
Cross-references
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| PROSITE | PS01047; HMA_1; 1; |
Features
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| From: PS50846 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="HMA #" | |||||||||
| BINDING | 12 | 12 | /ligand="a metal cation" /ligand_id="ChEBI:CHEBI:25213" /ligand_label="#1" |
C | 1 | |||||||
| BINDING | 15 | 15 | /ligand="a metal cation" /ligand_id="ChEBI:CHEBI:25213" /ligand_label="#1" |
C | 1 | |||||||
Additional information
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| Size range | 54-75 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-6 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [2] Bacteria [122] Eukaryota [113] All [ 237 ]
- Retrieve set of proteins with 3D structure for this domain