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ProRule PRU00298


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU00298
Accession PRU00298
Dates 12-DEC-2003 (Created)
4-NOV-2024 (Last updated, Version 23)
Data class Domain;
Predictors PROSITE; PS50292; PEROXIDASE_3
Name Animal heme peroxidase
Function Removal of H(2)O(2)
Scope(s) Eukaryota
Example(s) P11247 (PERM_MOUSE);

Propagated annotation [?]

Comments [?]

case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
CATALYTIC ACTIVITY Reaction=H2O2 + AH2 = A + 2 H2O; Xref=Rhea:RHEA:30275, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:17499;
COFACTOR Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per heterodimer.;
COFACTOR Name=heme b; Xref=ChEBI:CHEBI:60344; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer.;
end case
SIMILARITYBelongs to the peroxidase family.

Keywords [?]

case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
Oxidoreductase
Peroxidase
end case
case <FTGroup:1>
Iron
Heme
end case
case <FTGroup:3>
Calcium
end case
case <FTGroup:1> or <FTGroup:3>
Metal-binding
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
GO:0016491; Molecular function:oxidoreductase activity
GO:0004601; Molecular function:peroxidase activity
end case

Cross-references [?]

PROSITE PS00435; PEROXIDASE_1; 1;
PROSITE PS00436; PEROXIDASE_2; 1;

Features [?]

From: PS50292
Key From To Description Tag Condition FTGroup
case <Feature:PS50292:4=C> and <Feature:PS50292:111=C>
CHAIN 2 108 /note=" light chain"
CHAIN 109 Cter /note=" heavy chain"
end case
BINDING 95 95 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/note="covalent"		 D 1
BINDING 238 238 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/note="covalent"		 E 1
ACT_SITE 96 96 /note="Proton acceptor" H 2
SITE 235 235 /note="Transition state stabilizer" R 2
BINDING 97 97 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 D 3
BINDING 164 164 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 [ST] 3
BINDING 166 166 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 [FY] 3
BINDING 168 168 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 D 3
BINDING 170 170 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 [ST] 3
BINDING 332 332 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
DISULFID 4 17 disulf C-x*-C
DISULFID 111 121 disulf C-x*-C
DISULFID 115 139 disulf C-x*-C
DISULFID 217 228 disulf C-x*-C
DISULFID 435 491 disulf C-x*-C
DISULFID 534 560 disulf C-x*-C

Additional information [?]

Size range 510-750 amino acids
Related rules None
Fusion None
Repeats 1-6
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]