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annotation rule: PRU00298

General rule information [?]

Accession PRU00298
Dates 12-DEC-2003 (Created)
27-OCT-2018 (Last updated, Version 17)
Data class Domain
Predictors PROSITE; PS50292; PEROXIDASE_3
Name Animal heme peroxidase
Function Removal of H(2)O(2)

Propagated annotation [?]


Comments [?]

case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
Catalytic activity Reaction=AH2 + H2O2 = A + 2 H2O; Xref=Rhea:RHEA:30275, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:17499;.
Cofactor Ca(2+)
Note: Binds 1 Ca(2+) ion per heterodimer.
heme b
Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer.
end case

Similarity Belongs to the peroxidase family.

Cross-references [?]

case <FTGroup:2>
PROSITE PS00435; PEROXIDASE_1; 1;
PS00436; PEROXIDASE_2; 1;
end case


Gene Ontology [?]

case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
GO:0016491; Molecular function: oxidoreductase activity.
GO:0004601; Molecular function: peroxidase activity.

Keywords [?]

end case

case <FTGroup:1>
end case

case <FTGroup:3>
end case

case <FTGroup:1> or <FTGroup:3>
end case

case <FTTag:disulf>
end case


Features [?]

case <Feature:PS50292:4=C> and <Feature:PS50292:111=C>
From: PS50292
Key     From     To       Description   Tag   Condition   FTGroup
CHAIN     2     108       light chain        
CHAIN     109     Cter       heavy chain        

BINDING     95     95       Heme (covalent)     D   1
BINDING     238     238       Heme (covalent)     E   1
ACT_SITE     96     96       Proton acceptor     H   2
SITE     235     235       Transition state stabilizer     R   2
METAL     97     97       Calcium     D   3
METAL     164     164       Calcium     [ST]   3
METAL     166     166       Calcium; via carbonyl oxygen     [FY]   3
METAL     168     168       Calcium     D   3
METAL     170     170       Calcium     [ST]   3
METAL     332     332       Iron (heme axial ligand)     H  
DISULFID     4     17           disulf   C-x*-C  
DISULFID     111     121           disulf   C-x*-C  
DISULFID     115     139           disulf   C-x*-C  
DISULFID     217     228           disulf   C-x*-C  
DISULFID     435     491           disulf   C-x*-C  
DISULFID     534     560           disulf   C-x*-C  

Additional information [?]

Size range 510-750 amino acids
Related rules None
Repeats 1-6
Topology Undefined
Example P11247 (PERM_MOUSE)
Scope
Eukaryota

Copyright

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.



UniProtKB rule member sequences [?]