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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00298


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00298
General rule information [?]

Accession PRU00298
Dates 12-DEC-2003 (Created)
04-NOV-2024 (Last updated, Version 24)
Data class Domain;
Predictors PROSITE; PS50292; PEROXIDASE_3
Name Animal heme peroxidase
Function Removal of H(2)O(2)
Scope(s) Eukaryota
Example(s) P11247;

Propagated annotation [?]

Comments [?]

case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
CATALYTIC ACTIVITY Reaction=H2O2 + AH2 = A + 2 H2O; Xref=Rhea:RHEA:30275, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:17499;
COFACTOR Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per heterodimer.;
COFACTOR Name=heme b; Xref=ChEBI:CHEBI:60344; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer.;
end case
SIMILARITYBelongs to the peroxidase family.

Keywords [?]

case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
Oxidoreductase
Peroxidase
end case
case <FTGroup:1>
Iron
Heme
end case
case <FTGroup:3>
Calcium
end case
case <FTGroup:1> or <FTGroup:3>
Metal-binding
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
GO:0016491; Molecular function:oxidoreductase activity
GO:0004601; Molecular function:peroxidase activity
end case

Cross-references [?]

PROSITE PS00435; PEROXIDASE_1; 1;
PROSITE PS00436; PEROXIDASE_2; 1;

Features [?]

From: PS50292
Key From To Description Tag Condition FTGroup
case <Feature:PS50292:4=C> and <Feature:PS50292:111=C>
CHAIN 2 108 /note=" light chain"
CHAIN 109 Cter /note=" heavy chain"
end case
BINDING 95 95 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/note="covalent"		 D 1
BINDING 238 238 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/note="covalent"		 E 1
ACT_SITE 96 96 /note="Proton acceptor" H 2
SITE 235 235 /note="Transition state stabilizer" R 2
BINDING 97 97 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 D 3
BINDING 164 164 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 [ST] 3
BINDING 166 166 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 [FY] 3
BINDING 168 168 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 D 3
BINDING 170 170 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"		 [ST] 3
BINDING 332 332 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H
DISULFID 4 17 disulf C-x*-C
DISULFID 111 121 disulf C-x*-C
DISULFID 115 139 disulf C-x*-C
DISULFID 217 228 disulf C-x*-C
DISULFID 435 491 disulf C-x*-C
DISULFID 534 560 disulf C-x*-C

Additional information [?]

Size range 510-750 amino acids
Related rules None
Fusion None
Repeats 1-6
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]