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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00345


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00345
General rule information [?]

Accession PRU00345
Dates 01-JUN-2004 (Created)
27-JUN-2022 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS50995; HTH_MARR_2
Name MarR-type HTH domain
Function The marR-type HTH domain is a DNA-binding, winged helix-turn-helix (wHTH) domain of about 135 amino acids present in transcription regulators of the marR/slyA family, involved in the development of antibiotic resistance.
Scope(s) Bacteria
Archaea
Example(s) Q93CC3;

Propagated annotation [?]

Keywords [?]

DNA-binding
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Cross-references [?]

PROSITE PS01117; HTH_MARR_1; 1;

Features [?]

From: PS50995
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="HTH marR-type #"
DNA_BIND 47 70 /note="H-T-H motif"

Additional information [?]

Size range 120-160 amino acids
Related rules None
Fusion None
Repeats 1
Topology Cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]