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annotation rule: PRU00362

General rule information [?]

Accession PRU00362
Dates 11-OCT-2004 (Created)
19-NOV-2022 (Last updated, Version 20)
Data class Domain
Predictors PROSITE; PS50990; PEPTIDASE_C39
Name Peptidase family C39 domain
Function This domain is a thiol peptidase found in ABC transporters, and belongs to the C39 peptidase family.

Propagated annotation [?]


Description [?]

case (<Feature:PS50990:7=C> and <Feature:PS50990:81=H>)
+ RecName: EC 3.4.22.-;
end case


Cross-references [?]

PROSITE PS00211; ABC_TRANSPORTER_1; 1;
PS50893; ABC_TRANSPORTER_2; 1; trigger=PRU00434;
PS50990; PEPTIDASE_C39; 1;
PS50929; ABC_TM1F; 1;

Keywords [?]

case <OC:Bacteria> or <OC:Archaea>
Transport
end case

case (<OC:Bacteria> or <OC:Archaea>) and defined <Property:Membrane> and <Property:Membrane=2>
Membrane
Cell inner membrane
end case

case <OC:Bacteria> or <OC:Archaea>
Transmembrane
ATP-binding
Nucleotide-binding
end case

case (<Feature:PS50990:7=C> and <Feature:PS50990:81=H>)
Thiol protease
Hydrolase
Protease
end case


Features [?]

From: PS00017
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     from     to       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" /ligand_label="#        
From: PS50990
DOMAIN     from     to       Peptidase C39 #        
case <Feature:PS50990:7=C>
ACT_SITE     7     7                
else case <Feature:PS50990:81=H>
ACT_SITE     81     81                
end case


Additional information [?]

Size range 121 amino acids
Related rules PRU01700
Repeats 1
Topology Undefined
Example P08716 (HLYBP_ECOLX)
Scope
Bacteria
Archaea
Comments A number of the proteins are classified as non-peptidase homologues as they either have been found experimentally to be without peptidase activity, or to lack amino acid residues that are believed to be essential for the catalytic activity.

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]