ProRule PRU00362
General rule information
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| Accession | PRU00362 |
| Dates | 11-OCT-2004 (Created)
19-NOV-2022 (Last updated, Version 20) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50990; PEPTIDASE_C39 |
Name | Peptidase family C39 domain |
| Function | This domain is a thiol peptidase found in ABC transporters, and belongs to the C39 peptidase family. |
| Scope(s) |
Bacteria Archaea |
| Example(s) | P08716 (HLYBP_ECOLX); |
Propagated annotation
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Identifier, protein and gene names
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| case (<Feature:PS50990:7=C> and <Feature:PS50990:81=H>) | |
| Protein name | + RecName: EC=3.4.22.-; |
| end case | |
Keywords
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| case <OC:Bacteria> or <OC:Archaea> | |
| Transport | |
| end case | |
| case (<OC:Bacteria> or <OC:Archaea>) and defined <Property:Membrane> and <Property:Membrane=2> | |
| Membrane | |
| Cell inner membrane | |
| end case | |
| case <OC:Bacteria> or <OC:Archaea> | |
| Transmembrane | |
| ATP-binding | |
| Nucleotide-binding | |
| end case | |
| case (<Feature:PS50990:7=C> and <Feature:PS50990:81=H>) | |
| Thiol protease | |
| Hydrolase | |
| Protease | |
| end case | |
| case <Feature:PS50990:7=C> | |
Cross-references
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| PROSITE | PS00211; ABC_TRANSPORTER_1; 1; |
| PROSITE | PS50893; ABC_TRANSPORTER_2; 1; |
| PROSITE | PS50990; PEPTIDASE_C39; 1; |
| PROSITE | PS50929; ABC_TM1F; 1; |
Features
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| From: PS00017 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | from | to | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" /ligand_label="#" |
|||||||||
| From: PS50990 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase C39 #" | |||||||||
| case <Feature:PS50990:7=C> | ||||||||||||
| ACT_SITE | 7 | 7 | ||||||||||
| else case <Feature:PS50990:81=H> | ||||||||||||
| ACT_SITE | 81 | 81 | ||||||||||
| end case | ||||||||||||
Additional information
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| Size range | 121 amino acids |
| Related rules |
PRU01700 |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
| Comments | A number of the proteins are classified as non-peptidase homologues as they either have been found experimentally to be without peptidase activity, or to lack amino acid residues that are believed to be essential for the catalytic activity. |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [2] Bacteria [38] Viruses [1] All [ 41 ]
- Retrieve set of proteins with 3D structure for this domain