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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00362


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00362
General rule information [?]

Accession PRU00362
Dates 11-OCT-2004 (Created)
19-NOV-2022 (Last updated, Version 21)
Data class Domain;
Predictors PROSITE; PS50990; PEPTIDASE_C39
Name Peptidase family C39 domain
Function This domain is a thiol peptidase found in ABC transporters, and belongs to the C39 peptidase family.
Scope(s) Bacteria
Archaea
Example(s) P08716;

Propagated annotation [?]

Identifier, protein and gene names [?]

case (<Feature:PS50990:7=C> and <Feature:PS50990:81=H>)
Protein name + RecName: EC=3.4.22.-;
end case

Keywords [?]

case <OC:Bacteria> or <OC:Archaea>
Transport
end case
case (<OC:Bacteria> or <OC:Archaea>) and defined <Property:Membrane> and <Property:Membrane=2>
Membrane
Cell inner membrane
end case
case <OC:Bacteria> or <OC:Archaea>
Transmembrane
ATP-binding
Nucleotide-binding
end case
case (<Feature:PS50990:7=C> and <Feature:PS50990:81=H>)
Thiol protease
Hydrolase
Protease
end case
case <Feature:PS50990:7=C>

Cross-references [?]

PROSITE PS00211; ABC_TRANSPORTER_1; 1;
PROSITE PS50893; ABC_TRANSPORTER_2; 1;
PROSITE PS50990; PEPTIDASE_C39; 1;
PROSITE PS50929; ABC_TM1F; 1;

Features [?]

From: PS00017
Key From To Description Tag Condition FTGroup
BINDING from to /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
/ligand_label="#"
From: PS50990
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C39 #"
case <Feature:PS50990:7=C>
ACT_SITE 7 7
else case <Feature:PS50990:81=H>
ACT_SITE 81 81
end case

Additional information [?]

Size range 121 amino acids
Related rules PRU01700
Fusion None
Repeats 1
Topology Undefined
Comments A number of the proteins are classified as non-peptidase homologues as they either have been found experimentally to be without peptidase activity, or to lack amino acid residues that are believed to be essential for the catalytic activity.

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]