PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00385


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00385
General rule information [?]

Accession PRU00385
Dates 18-JAN-2005 (Created)
29-SEP-2022 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS51049; KASH
Name KASH domain
Function The KASH or KLS domain is a highly hydrophobic nuclear envelope localization domain of ~60 amino acids comprising an ~20-amino-acid transmembrane region and a 30-35-residue C-terminal region that lies between the inner and the outer nuclear membranes.
Scope(s) Eukaryota
Metazoa
Example(s) Q8NF91;

Propagated annotation [?]

Keywords [?]

Membrane
Transmembrane

Gene Ontology [?]

GO:0016020; Cellular component:membrane

Cross-references [?]

General Transmembrane; -; 1;

Features [?]

From: PS51049
Key From To Description Tag Condition FTGroup
TOPO_DOM Nter 9 /note="Cytoplasmic"
TRANSMEM 10 30 /note="Helical; Anchor for type IV membrane protein"
TOPO_DOM 31 Cter /note="Perinuclear space"
DOMAIN from to /note="KASH #"

Additional information [?]

Size range 55-65 amino acids
Related rules None
Fusion None
Repeats 1
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]