General rule information
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Accession |
PRU00385 |
Dates |
18-JAN-2005 (Created) 21-NOV-2019 (Last updated, Version 11) |
Function |
The KASH or KLS domain is a highly hydrophobic nuclear envelope localization domain of ~60 amino acids comprising an ~20-amino-acid transmembrane region and a 30-35-residue C-terminal region that lies between the inner and the outer nuclear membranes. |
Propagated annotation
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General |
Transmembrane; -; 1; |
GO:0016021; Cellular component: integral component of membrane.
GO:0016020; Cellular component: membrane.
From: PS51049 |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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TOPO_DOM
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Nter
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9
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Cytoplasmic
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TRANSMEM
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10
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30
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Helical; Anchor for type IV membrane protein
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TOPO_DOM
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31
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Cter
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Perinuclear space
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DOMAIN
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from
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to
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KASH #
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Additional information
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Size range |
55-65 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Not cytoplasmic |
Example |
Q8NF91 (SYNE1_HUMAN) |
Scope |
Eukaryota; Metazoa |
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distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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