ProRule PRU00385

General rule information [?]

Accession PRU00385
Dates 18-JAN-2005 (Created)
29-SEP-2022 (Last updated, Version 12)
Data class Domain;
Predictors PROSITE; PS51049; KASH
Name KASH domain
Function The KASH or KLS domain is a highly hydrophobic nuclear envelope localization domain of ~60 amino acids comprising an ~20-amino-acid transmembrane region and a 30-35-residue C-terminal region that lies between the inner and the outer nuclear membranes.
Scope(s) Eukaryota
Example(s) Q8NF91 (SYNE1_HUMAN);

Propagated annotation [?]

Keywords [?]

Gene Ontology [?]

GO:0016020; Cellular component:membrane

Cross-references [?]

General Transmembrane; -; 1;

Features [?]

From: PS51049
Key From To Description Tag Condition FTGroup
TOPO_DOM Nter 9 /note="Cytoplasmic"
TRANSMEM 10 30 /note="Helical; Anchor for type IV membrane protein"
TOPO_DOM 31 Cter /note="Perinuclear space"
DOMAIN from to /note="KASH #"

Additional information [?]

Size range 55-65 amino acids
Related rules None
Fusion None
Repeats 1
Topology Not cytoplasmic


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UniProtKB rule member sequences [?]