PRU00385
General rule information
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| Accession | PRU00385 |
| Dates | 18-JAN-2005 (Created) 29-SEP-2022 (Last updated, Version 12) |
| Data class | Domain |
| Predictors | PROSITE; PS51049; KASH |
| Name | KASH domain |
| Function | The KASH or KLS domain is a highly hydrophobic nuclear envelope localization domain of ~60 amino acids comprising an ~20-amino-acid transmembrane region and a 30-35-residue C-terminal region that lies between the inner and the outer nuclear membranes. |
Propagated annotation
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Computed features
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| General | Transmembrane; -; 1; |
Gene Ontology
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GO:0016020; Cellular component: membrane.
Keywords
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Features
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| From: PS51049 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 9 | Cytoplasmic | |||||||||
| TRANSMEM | 10 | 30 | Helical; Anchor for type IV membrane protein | |||||||||
| TOPO_DOM | 31 | Cter | Perinuclear space | |||||||||
| DOMAIN | from | to | KASH # | |||||||||
Additional information
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| Size range | 55-65 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Not cytoplasmic |
| Example | Q8NF91 (SYNE1_HUMAN) |
| Scope | Eukaryota; Metazoa |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [21]
- Retrieve set of proteins with 3D structure for this domain