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annotation rule: PRU00385

General rule information [?]

Accession PRU00385
Dates 18-JAN-2005 (Created)
21-NOV-2019 (Last updated, Version 11)
Data class Domain
Predictors PROSITE; PS51049; KASH
Name KASH domain
Function The KASH or KLS domain is a highly hydrophobic nuclear envelope localization domain of ~60 amino acids comprising an ~20-amino-acid transmembrane region and a 30-35-residue C-terminal region that lies between the inner and the outer nuclear membranes.

Propagated annotation [?]


Computed features [?]

General Transmembrane; -; 1;

Gene Ontology [?]

GO:0016021; Cellular component: integral component of membrane.
GO:0016020; Cellular component: membrane.

Keywords [?]

Membrane
Transmembrane

Features [?]

From: PS51049
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     9       Cytoplasmic        
TRANSMEM     10     30       Helical; Anchor for type IV membrane protein        
TOPO_DOM     31     Cter       Perinuclear space        
DOMAIN     from     to       KASH #        

Additional information [?]

Size range 55-65 amino acids
Related rules None
Repeats 1
Topology Not cytoplasmic
Example Q8NF91 (SYNE1_HUMAN)
Scope
Eukaryota; Metazoa

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]