ProRule PRU00385
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00385 |
| Accession | PRU00385 |
| Dates | 18-JAN-2005 (Created)
29-SEP-2022 (Last updated, Version 12) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51049; KASH |
Name | KASH domain |
| Function | The KASH or KLS domain is a highly hydrophobic nuclear envelope localization domain of ~60 amino acids comprising an ~20-amino-acid transmembrane region and a 30-35-residue C-terminal region that lies between the inner and the outer nuclear membranes. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q8NF91 (SYNE1_HUMAN); |
Propagated annotation
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Keywords
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Gene Ontology
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| GO:0016020; Cellular component:membrane |
Cross-references
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| General | Transmembrane; -; 1; |
Features
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| From: PS51049 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 9 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 10 | 30 | /note="Helical; Anchor for type IV membrane protein" | |||||||||
| TOPO_DOM | 31 | Cter | /note="Perinuclear space" | |||||||||
| DOMAIN | from | to | /note="KASH #" | |||||||||
Additional information
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| Size range | 55-65 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Not cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [21] All [ 21 ]
- Retrieve set of proteins with 3D structure for this domain