ProRule PRU00387
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PURL: https://purl.expasy.org/prosite/rule/PRU00387
        General rule information
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    | Accession | PRU00387 | 
| Dates | 20-JAN-2005 (Created) 27-JUN-2022 (Last updated, Version 10) | 
| Data class | Domain; | 
| Predictors | PROSITE; PS51063; HTH_CRP_2 | Name | Crp-type HTH domain | 
| Function | The crp-type HTH domain is a DNA-binding, winged helix-turn-helix (wHTH) domain of about 70-75 amino acids present in transcription regulators of the crp-fnr family, involved in the control of virulence factors, enzymes of aromatic ring degradation, nitrogen fixation, photosynthesis, and various types of respiration. | 
| Scope(s) | Bacteria Plastid | 
| Example(s) | P27369 (CYSR_SYNE7); | 
        Propagated annotation
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    Keywords
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    Gene Ontology
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    | GO:0003677; Molecular function:DNA binding | 
| GO:0006355; Biological process:regulation of DNA-templated transcription | 
| GO:0006351; Biological process:DNA-templated transcription | 
    
    Cross-references
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    | PROSITE | PS00042; HTH_CRP_1; 1; | 
    
    Features
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    | From: PS51063 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="HTH crp-type #" | |||||||||
| DNA_BIND | 43 | 62 | /note="H-T-H motif" | |||||||||
    
    Additional information
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    | Size range | 40-90 amino acids | 
| Related rules | None | 
| Fusion | None | 
| Repeats | 1 | 
| Topology | Cytoplasmic | 
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UniProtKB rule member sequences
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    - UniProtKB/Swiss-Prot sets
 Archaea [1] Bacteria [85] Eukaryota [2] All [ 88 ] 
 
- Retrieve set of proteins with 3D structure for this domain
