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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00388


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00388
General rule information [?]

Accession PRU00388
Dates 21-JAN-2005 (Created)
15-APR-2020 (Last updated, Version 15)
Data class Domain;
Predictors PROSITE; PS50127; UBC_2
Name Ubiquitin-conjugating (UBC) core domain
Function Catalyzes the covalent attachment of ubiquitin to target proteins.
Scope(s) Eukaryota
Example(s) P52484;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTTag:act_site>
Protein name + RecName: EC= 2.3.2.-;
end case

Comments [?]

SIMILARITYBelongs to the ubiquitin-conjugating enzyme family.

Keywords [?]

Transferase
Ubl conjugation pathway
end case

Gene Ontology [?]

GO:0016874; Molecular function:ligase activity
end case

Cross-references [?]

PROSITE PS00183; UBIQUITIN_CONJUGAT_1; 1;

Features [?]

From: PS50127
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="UBC core #"
ACT_SITE 85 85 /note="Glycyl thioester intermediate" act_site C

Additional information [?]

Size range 100-170 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]