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annotation rule: PRU00392

General rule information [?]

Accession PRU00392
Dates 7-FEB-2005 (Created)
27-OCT-2018 (Last updated, Version 9)
Data class Domain
Predictors PROSITE; PS51068; FPG_CAT
Name Formamidopyrimidine-DNA glycosylase catalytic domain
Function DNA glycosylase

Propagated annotation [?]


Description [?]

case <FTGroup:1>
+ AltName: EC=3.2.2.-; EC=4.2.99.18;

Comments [?]

Function Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases.
Catalytic activity Reaction=The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'- terminal unsaturated sugar and a product with a terminal 5'- phosphate.; EC=4.2.99.18;.
Similarity Belongs to the FPG family.
end case


Gene Ontology [?]

case <FTGroup:1>
GO:0006974; Biological process: cellular response to DNA damage stimulus.
GO:0006281; Biological process: DNA repair.
GO:0003677; Molecular function: DNA binding.
GO:0016798; Molecular function: hydrolase activity, acting on glycosyl bonds.
GO:0016787; Molecular function: hydrolase activity.
GO:0016829; Molecular function: lyase activity.
GO:0003824; Molecular function: catalytic activity.

Keywords [?]

end case


Features [?]

From: PS51068
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     1     1       Schiff-base intermediate with DNA     P   1
ACT_SITE     2     2       Proton donor     E   1
ACT_SITE     57     57       Proton donor (in beta-elimination)     K   1

Additional information [?]

Size range 70-150 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P05523 (FPG_ECOLI)
Scope
Eukaryota
Bacteria
Archaea

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]