ProRule PRU00393
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PURL: https://purl.expasy.org/prosite/rule/PRU00393
        General rule information
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    | Accession | PRU00393 | 
| Dates | 08-FEB-2005 (Created) 27-JUN-2022 (Last updated, Version 11) | 
| Data class | Domain; | 
| Predictors | PROSITE; PS51077; HTH_ICLR | Name | IclR-type HTH domain | 
| Function | The iclR-type HTH domain is a DNA-binding, winged helix-turn-helix (wHTH) domain of about 60 amino acids present in transcription regulators of the iclR family, involved in carbon metabolism in eubacteria and archaea. | 
| Scope(s) | Bacteria Archaea Viruses | 
| Example(s) | P37728 (KDGR_DICCH); | 
        Propagated annotation
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    Keywords
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    Gene Ontology
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    | GO:0003677; Molecular function:DNA binding | 
| GO:0006355; Biological process:regulation of DNA-templated transcription | 
| GO:0006351; Biological process:DNA-templated transcription | 
    
    Features
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    | From: PS51077 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="HTH iclR-type #" | |||||||||
| DNA_BIND | 23 | 42 | /note="H-T-H motif" | |||||||||
    
    Additional information
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    | Size range | 50-75 amino acids | 
| Related rules | None | 
| Fusion | None | 
| Repeats | 1-2 | 
| Topology | Cytoplasmic | 
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UniProtKB rule member sequences
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    - UniProtKB/Swiss-Prot sets
 Archaea [2] Bacteria [33] Eukaryota [15] All [ 50 ] 
 
- Retrieve set of proteins with 3D structure for this domain
