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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00393


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00393
General rule information [?]

Accession PRU00393
Dates 08-FEB-2005 (Created)
27-JUN-2022 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS51077; HTH_ICLR
Name IclR-type HTH domain
Function The iclR-type HTH domain is a DNA-binding, winged helix-turn-helix (wHTH) domain of about 60 amino acids present in transcription regulators of the iclR family, involved in carbon metabolism in eubacteria and archaea.
Scope(s) Bacteria
Archaea
Viruses
Example(s) P37728;

Propagated annotation [?]

Keywords [?]

DNA-binding
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Features [?]

From: PS51077
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="HTH iclR-type #"
DNA_BIND 23 42 /note="H-T-H motif"

Additional information [?]

Size range 50-75 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]