We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00395
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00395
General rule information
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| Accession | PRU00395 |
| Dates | 10-FEB-2005 (Created)
21-NOV-2019 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51052; CYCLOTIDE |
Name | Cyclotides |
| Function | Cyclotides (cyclo peptides) are plant peptides of ~30 amino acids with a head-to-tail cyclic backbone and six cysteine residues involved in three disulfide bonds. They are most likely present as defense molecules. |
| Scope(s) |
Eukaryota Viridiplantae |
| Example(s) | P58433; P56254; |
Propagated annotation
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Comments
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| FUNCTION | Probably participates in a plant defense mechanism. |
| PTM | This is a cyclic peptide. |
| case <Feature:PS60008> and not <Feature:PS60009> | |
| SIMILARITY | Belongs to the cyclotide family. Bracelet subfamily. |
| else case <Feature:PS60009> and not <Feature:PS60008> | |
| SIMILARITY | Belongs to the cyclotide family. Moebius subfamily. |
| else | |
| SIMILARITY | Belongs to the cyclotide family. |
| end case | |
| CAUTION | This peptide is cyclic. The start position was chosen by similarity to Oak1 (kalata B1) for which the DNA sequence is known. |
Keywords
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| case <Feature:PS60008> and not <Feature:PS60009> | |
| else case <Feature:PS60009> and not <Feature:PS60008> | |
| Plant defense | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Cross-references
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Features
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| From: PS51052 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| PEPTIDE | from | to | /note=" |
|||||||||
| DISULFID | 5 | 19 | disulf | C-x*-C | ||||||||
| DISULFID | 9 | 21 | disulf | C-x*-C | ||||||||
| DISULFID | 14 | 26 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 20-35 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-3 |
| Topology | Not cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [222] All [ 222 ]
- Retrieve set of proteins with 3D structure for this domain