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annotation rule: PRU00395

General rule information [?]

Accession PRU00395
Dates 10-FEB-2005 (Created)
21-NOV-2019 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS51052; CYCLOTIDE
Name Cyclotides
Function Cyclotides (cyclo peptides) are plant peptides of ~30 amino acids with a head-to-tail cyclic backbone and six cysteine residues involved in three disulfide bonds. They are most likely present as defense molecules.

Propagated annotation [?]

Comments [?]

Function Probably participates in a plant defense mechanism.
Ptm This is a cyclic peptide.
case <Feature:PS60008> and not <Feature:PS60009>
Similarity Belongs to the cyclotide family. Bracelet subfamily.
else case <Feature:PS60009> and not <Feature:PS60008>
Similarity Belongs to the cyclotide family. Moebius subfamily.
Similarity Belongs to the cyclotide family.
end case

Caution This peptide is cyclic. The start position was chosen by similarity to Oak1 (kalata B1) for which the DNA sequence is known.

Cross-references [?]


Keywords [?]

case <FTTag:disulf>
end case

Features [?]

From: PS51052
Key     From     To       Description   Tag   Condition   FTGroup
PEPTIDE     from     to              
DISULFID     5     19           disulf   C-x*-C  
DISULFID     9     21           disulf   C-x*-C  
DISULFID     14     26           disulf   C-x*-C  

Additional information [?]

Size range 20-35 amino acids
Related rules None
Repeats 1-3
Topology Not cytoplasmic
Examples P58433 (CYH1_VIOHE); P56254 (KAB1_OLDAF): [Recover all]
Eukaryota; Viridiplantae; Embryophyta


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]