ProRule PRU00395
General rule information
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Accession | PRU00395 |
Dates | 10-FEB-2005 (Created)
21-NOV-2019 (Last updated, Version 5) |
Data class | Domain; |
Predictors |
PROSITE; PS51052; CYCLOTIDE |
Name | Cyclotides |
Function | Cyclotides (cyclo peptides) are plant peptides of ~30 amino acids with a head-to-tail cyclic backbone and six cysteine residues involved in three disulfide bonds. They are most likely present as defense molecules. |
Scope(s) |
Eukaryota Viridiplantae |
Example(s) | P58433 (CYH1_VIOHE); P56254 (KAB1_OLDAF); |
Propagated annotation
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Comments
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FUNCTION | Probably participates in a plant defense mechanism. |
PTM | This is a cyclic peptide. |
case <Feature:PS60008> and not <Feature:PS60009> | |
SIMILARITY | Belongs to the cyclotide family. Bracelet subfamily. |
else case <Feature:PS60009> and not <Feature:PS60008> | |
SIMILARITY | Belongs to the cyclotide family. Moebius subfamily. |
else | |
SIMILARITY | Belongs to the cyclotide family. |
end case | |
CAUTION | This peptide is cyclic. The start position was chosen by similarity to Oak1 (kalata B1) for which the DNA sequence is known. |
Keywords
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case <Feature:PS60008> and not <Feature:PS60009> | |
else case <Feature:PS60009> and not <Feature:PS60008> | |
Plant defense | |
case <FTTag:disulf> | |
Disulfide bond | |
end case |
Cross-references
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Features
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From: PS51052 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
PEPTIDE | from | to | /note=" |
|||||||||
DISULFID | 5 | 19 | disulf | C-x*-C | ||||||||
DISULFID | 9 | 21 | disulf | C-x*-C | ||||||||
DISULFID | 14 | 26 | disulf | C-x*-C |
Additional information
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Size range | 20-35 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1-3 |
Topology | Not cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [222] All [ 222 ]
- Retrieve set of proteins with 3D structure for this domain