ProRule PRU00399

General rule information [?]

Accession PRU00399
Dates 14-FEB-2005 (Created)
19-NOV-2022 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS51062; RUNT
Name Runt domain
Function The Runt domain confers DNA binding ability to the consensus core PyGPyGGT and mediates the interaction of mammalian RUNX proteins with the beta-subunit, designated core-binding factor beta (CBFbeta), which increases the DNA binding affinity of the heterodimer.
Scope(s) Eukaryota
Example(s) Q01196 (RUNX1_HUMAN);

Propagated annotation [?]

Comments [?]


Keywords [?]

case <FTGroup:1> or <FTGroup:2>
end case
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0005634; Cellular component:nucleus
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Features [?]

From: PS51062
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Runt #"
REGION 31 35 /note="Interaction with DNA"
REGION 86 94 /note="Interaction with DNA"
REGION 119 128 /note="Interaction with DNA"
BINDING 63 63 /ligand="chloride"
N 1
BINDING 67 67 /ligand="chloride"
E 1
BINDING 90 90 /ligand="chloride"
R 2
BINDING 121 121 /ligand="chloride"
V 2

Additional information [?]

Size range 125-135 amino acids
Related rules None
Fusion None
Repeats 1
Topology Not cytoplasmic


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB rule member sequences [?]