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annotation rule: PRU00399

General rule information [?]

Accession PRU00399
Dates 14-FEB-2005 (Created)
21-NOV-2019 (Last updated, Version 7)
Data class Domain
Predictors PROSITE; PS51062; RUNT
Name Runt domain
Function The Runt domain confers DNA binding ability to the consensus core PyGPyGGT and mediates the interaction of mammalian RUNX proteins with the beta-subunit, designated core-binding factor beta (CBFbeta), which increases the DNA binding affinity of the heterodimer.

Propagated annotation [?]

Comments [?]

Subcellular location Nucleus.

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0005634; Cellular component: nucleus.
GO:0006355; Biological process: regulation of transcription, DNA-templated.
GO:0006351; Biological process: transcription, DNA-templated.

Keywords [?]

case <FTGroup:1> or <FTGroup:2>
end case

Features [?]

From: PS51062
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Runt #        
SITE     31     35       Interaction with DNA        
SITE     86     94       Interaction with DNA        
SITE     119     128       Interaction with DNA        
BINDING     63     63       Chloride #1     N   1
BINDING     67     67       Chloride #1     E   1
BINDING     90     90       Chloride #2     R   2
BINDING     121     121       Chloride #2     V   2

Additional information [?]

Size range 125-135 amino acids
Related rules None
Repeats 1
Topology Not cytoplasmic
Example Q01196 (RUNX1_HUMAN)
Eukaryota; Metazoa


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]