We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00399
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00399
General rule information
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| Accession | PRU00399 |
| Dates | 14-FEB-2005 (Created)
19-NOV-2022 (Last updated, Version 12) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51062; RUNT |
Name | Runt domain |
| Function | The Runt domain confers DNA binding ability to the consensus core PyGPyGGT and mediates the interaction of mammalian RUNX proteins with the beta-subunit, designated core-binding factor beta (CBFbeta), which increases the DNA binding affinity of the heterodimer. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q01196; |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Nucleus. |
Keywords
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| case <FTGroup:1> or <FTGroup:2> | |
| Chloride | |
| end case | |
| DNA-binding | |
| Nucleus | |
| Transcription | |
| Transcription regulation | |
Gene Ontology
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| GO:0003677; Molecular function:DNA binding |
| GO:0005634; Cellular component:nucleus |
| GO:0006355; Biological process:regulation of DNA-templated transcription |
| GO:0006351; Biological process:DNA-templated transcription |
Features
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| From: PS51062 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Runt #" | |||||||||
| REGION | 31 | 35 | /note="Interaction with DNA" | |||||||||
| REGION | 86 | 94 | /note="Interaction with DNA" | |||||||||
| REGION | 119 | 128 | /note="Interaction with DNA" | |||||||||
| BINDING | 63 | 63 | /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#1" |
N | 1 | |||||||
| BINDING | 67 | 67 | /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#1" |
E | 1 | |||||||
| BINDING | 90 | 90 | /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#2" |
R | 2 | |||||||
| BINDING | 121 | 121 | /ligand="chloride" /ligand_id="ChEBI:CHEBI:17996" /ligand_label="#2" |
V | 2 | |||||||
Additional information
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| Size range | 125-135 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Not cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [14] All [ 14 ]
- Retrieve set of proteins with 3D structure for this domain