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annotation rule: PRU00407

General rule information [?]

Accession PRU00407
Dates 2-MAR-2005 (Created)
27-JUN-2022 (Last updated, Version 17)
Data class Domain
Predictors PROSITE; PS51030; NUCLEAR_REC_DBD_2
Name Nuclear hormone receptors DNA-binding domain
Function Nuclear hormone receptors are ligand-activated transcription factors that regulate gene expression by interacting with specific DNA sequences upstream of their target genes.

Propagated annotation [?]


Comments [?]

Subcellular location Nucleus.

Cross-references [?]

PROSITE PS00031; NUCLEAR_REC_DBD_1; 1;

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0006351; Biological process: DNA-templated transcription.
GO:0005634; Cellular component: nucleus.
case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]> or <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]>
GO:0046872; Molecular function: metal ion binding.
GO:0008270; Molecular function: zinc ion binding.
end case


Keywords [?]

DNA-binding
Nucleus
Transcription
Transcription regulation
Zinc-finger
case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]> or <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]>
Zinc
Metal-binding
end case


Features [?]

From: PS51030
Key     From     To       Description   Tag   Condition   FTGroup
DNA_BIND     from     to       Nuclear receptor #        
case <Feature:PS51030:4=[C]> and <Feature:PS51030:7=[C]> and <Feature:PS51030:21=[C]> and <Feature:PS51030:24=[C]>
ZN_FING     4     24       NR C4-type        
else case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]>
ZN_FING     4     24       NR C4-type; atypical        
else
ZN_FING     4     24       NR C4-type; degenerate        
end case

case <Feature:PS51030:40=[C]> and <Feature:PS51030:46=[C]> and <Feature:PS51030:56=[C]> and <Feature:PS51030:59=[C]>
ZN_FING     40     59       NR C4-type        
else case <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]>
ZN_FING     40     59       NR C4-type; atypical        
else
ZN_FING     40     59       NR C4-type; degenerate        
end case


Additional information [?]

Size range 30-80 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9W539 (HR4_DROME)
Scope
Eukaryota
Viruses

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]