General rule information
[?]
Accession |
PRU00407 |
Dates |
2-MAR-2005 (Created) 27-JUN-2022 (Last updated, Version 17) |
Predictors |
PROSITE; PS51030; NUCLEAR_REC_DBD_2
|
Name |
Nuclear hormone receptors DNA-binding domain |
Function |
Nuclear hormone receptors are ligand-activated transcription factors that regulate gene expression by interacting with specific DNA sequences upstream of their target genes. |
Propagated annotation
[?]
Subcellular location |
Nucleus. |
PROSITE |
PS00031; NUCLEAR_REC_DBD_1; 1; |
GO:0003677; Molecular function: DNA binding.
GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0006351; Biological process: DNA-templated transcription.
GO:0005634; Cellular component: nucleus.
case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]> or <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]>
GO:0046872; Molecular function: metal ion binding.
GO:0008270; Molecular function: zinc ion binding.
end case
case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]> or <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]>
end case
From: PS51030 |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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DNA_BIND
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from
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to
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Nuclear receptor #
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case <Feature:PS51030:4=[C]> and <Feature:PS51030:7=[C]> and <Feature:PS51030:21=[C]> and <Feature:PS51030:24=[C]>
else case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]>
ZN_FING
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4
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24
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NR C4-type; atypical
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else
ZN_FING
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4
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24
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NR C4-type; degenerate
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end case
case <Feature:PS51030:40=[C]> and <Feature:PS51030:46=[C]> and <Feature:PS51030:56=[C]> and <Feature:PS51030:59=[C]>
else case <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]>
ZN_FING
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40
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59
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NR C4-type; atypical
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else
ZN_FING
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40
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59
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NR C4-type; degenerate
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end case
Additional information
[?]
Size range |
30-80 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q9W539 (HR4_DROME) |
Scope |
Eukaryota
Viruses |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]