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ProRule PRU00407


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PURL: https://purl.expasy.org/prosite/rule/PRU00407
General rule information [?]

Accession PRU00407
Dates 02-MAR-2005 (Created)
27-JUN-2022 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS51030; NUCLEAR_REC_DBD_2
Name Nuclear hormone receptors DNA-binding domain
Function Nuclear hormone receptors are ligand-activated transcription factors that regulate gene expression by interacting with specific DNA sequences upstream of their target genes.
Scope(s) Eukaryota
Viruses
Example(s) Q9W539;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.

Keywords [?]

DNA-binding
Nucleus
Transcription
Transcription regulation
Zinc-finger
case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]> or <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]>
Zinc
Metal-binding
end case

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription
GO:0005634; Cellular component:nucleus
case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]> or <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]>
GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

PROSITE PS00031; NUCLEAR_REC_DBD_1; 1;

Features [?]

From: PS51030
Key From To Description Tag Condition FTGroup
DNA_BIND from to /note="Nuclear receptor #"
case <Feature:PS51030:4=[C]> and <Feature:PS51030:7=[C]> and <Feature:PS51030:21=[C]> and <Feature:PS51030:24=[C]>
ZN_FING 4 24 /note="NR C4-type"
else case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]>
ZN_FING 4 24 /note="NR C4-type; atypical"
else
ZN_FING 4 24 /note="NR C4-type; degenerate"
end case
case <Feature:PS51030:40=[C]> and <Feature:PS51030:46=[C]> and <Feature:PS51030:56=[C]> and <Feature:PS51030:59=[C]>
ZN_FING 40 59 /note="NR C4-type"
else case <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]>
ZN_FING 40 59 /note="NR C4-type; atypical"
else
ZN_FING 40 59 /note="NR C4-type; degenerate"
end case

Additional information [?]

Size range 30-80 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]