ProRule PRU00407
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00407 |
| Accession | PRU00407 |
| Dates | 2-MAR-2005 (Created)
27-JUN-2022 (Last updated, Version 17) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51030; NUCLEAR_REC_DBD_2 |
Name | Nuclear hormone receptors DNA-binding domain |
| Function | Nuclear hormone receptors are ligand-activated transcription factors that regulate gene expression by interacting with specific DNA sequences upstream of their target genes. |
| Scope(s) |
Eukaryota Viruses |
| Example(s) | Q9W539 (HR4_DROME); |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Nucleus. |
Keywords
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| DNA-binding | |
| Nucleus | |
| Transcription | |
| Transcription regulation | |
| Zinc-finger | |
| case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]> or <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]> | |
| Zinc | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0003677; Molecular function:DNA binding | |
| GO:0006355; Biological process:regulation of DNA-templated transcription | |
| GO:0006351; Biological process:DNA-templated transcription | |
| GO:0005634; Cellular component:nucleus | |
| case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]> or <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]> | |
| GO:0046872; Molecular function:metal ion binding | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
Cross-references
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| PROSITE | PS00031; NUCLEAR_REC_DBD_1; 1; |
Features
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| From: PS51030 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DNA_BIND | from | to | /note="Nuclear receptor #" | |||||||||
| case <Feature:PS51030:4=[C]> and <Feature:PS51030:7=[C]> and <Feature:PS51030:21=[C]> and <Feature:PS51030:24=[C]> | ||||||||||||
| ZN_FING | 4 | 24 | /note="NR C4-type" | |||||||||
| else case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]> | ||||||||||||
| ZN_FING | 4 | 24 | /note="NR C4-type; atypical" | |||||||||
| else | ||||||||||||
| ZN_FING | 4 | 24 | /note="NR C4-type; degenerate" | |||||||||
| end case | ||||||||||||
| case <Feature:PS51030:40=[C]> and <Feature:PS51030:46=[C]> and <Feature:PS51030:56=[C]> and <Feature:PS51030:59=[C]> | ||||||||||||
| ZN_FING | 40 | 59 | /note="NR C4-type" | |||||||||
| else case <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]> | ||||||||||||
| ZN_FING | 40 | 59 | /note="NR C4-type; atypical" | |||||||||
| else | ||||||||||||
| ZN_FING | 40 | 59 | /note="NR C4-type; degenerate" | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 30-80 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [485] Viruses [1] All [ 486 ]
- Retrieve set of proteins with 3D structure for this domain