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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00407


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00407
General rule information [?]

Accession PRU00407
Dates 02-MAR-2005 (Created)
27-JUN-2022 (Last updated, Version 18)
Data class Domain;
Predictors PROSITE; PS51030; NUCLEAR_REC_DBD_2
Name Nuclear hormone receptors DNA-binding domain
Function Nuclear hormone receptors are ligand-activated transcription factors that regulate gene expression by interacting with specific DNA sequences upstream of their target genes.
Scope(s) Eukaryota
Viruses
Example(s) Q9W539;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.

Keywords [?]

DNA-binding
Nucleus
Transcription
Transcription regulation
Zinc-finger
case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]> or <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]>
Zinc
Metal-binding
end case

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription
GO:0005634; Cellular component:nucleus
case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]> or <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]>
GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

PROSITE PS00031; NUCLEAR_REC_DBD_1; 1;

Features [?]

From: PS51030
Key From To Description Tag Condition FTGroup
DNA_BIND from to /note="Nuclear receptor #"
case <Feature:PS51030:4=[C]> and <Feature:PS51030:7=[C]> and <Feature:PS51030:21=[C]> and <Feature:PS51030:24=[C]>
ZN_FING 4 24 /note="NR C4-type"
else case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]>
ZN_FING 4 24 /note="NR C4-type; atypical"
else
ZN_FING 4 24 /note="NR C4-type; degenerate"
end case
case <Feature:PS51030:40=[C]> and <Feature:PS51030:46=[C]> and <Feature:PS51030:56=[C]> and <Feature:PS51030:59=[C]>
ZN_FING 40 59 /note="NR C4-type"
else case <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]>
ZN_FING 40 59 /note="NR C4-type; atypical"
else
ZN_FING 40 59 /note="NR C4-type; degenerate"
end case

Additional information [?]

Size range 30-80 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]