ProRule PRU00407

Accession	PRU00407
Dates	2-MAR-2005 (Created) 27-JUN-2022 (Last updated, Version 17)
Data class	Domain;
Predictors	PROSITE; PS51030; NUCLEAR_REC_DBD_2
Name	Nuclear hormone receptors DNA-binding domain
Function	Nuclear hormone receptors are ligand-activated transcription factors that regulate gene expression by interacting with specific DNA sequences upstream of their target genes.
Scope(s)	Eukaryota Viruses
Example(s)	Q9W539 (HR4_DROME);

From: PS51030
Key	From	To	Description	Tag	Condition	FTGroup
DNA_BIND	from	to	/note="Nuclear receptor #"
case <Feature:PS51030:4=[C]> and <Feature:PS51030:7=[C]> and <Feature:PS51030:21=[C]> and <Feature:PS51030:24=[C]>
ZN_FING	4	24	/note="NR C4-type"
else case <Feature:PS51030:4=[CH]> and <Feature:PS51030:7=[CH]> and <Feature:PS51030:21=[CH]> and <Feature:PS51030:24=[CH]>
ZN_FING	4	24	/note="NR C4-type; atypical"
else
ZN_FING	4	24	/note="NR C4-type; degenerate"
end case
case <Feature:PS51030:40=[C]> and <Feature:PS51030:46=[C]> and <Feature:PS51030:56=[C]> and <Feature:PS51030:59=[C]>
ZN_FING	40	59	/note="NR C4-type"
else case <Feature:PS51030:40=[CH]> and <Feature:PS51030:46=[CH]> and <Feature:PS51030:56=[CH]> and <Feature:PS51030:59=[CH]>
ZN_FING	40	59	/note="NR C4-type; atypical"
else
ZN_FING	40	59	/note="NR C4-type; degenerate"
end case