ProRule PRU00408
General rule information
[?]
| Accession | PRU00408 |
| Dates | 3-MAR-2005 (Created)
19-NOV-2022 (Last updated, Version 19) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50879; RNASE_H_1 |
Name | Ribonuclease H type-1 domain |
| Function | Ribonuclease H (RNase H) (EC 3.1.26.4) recognizes and cleaves the RNA strand of RNA-DNA heteroduplexes. |
| Scope(s) |
Eukaryota Bacteria Archaea Viruses |
| Example(s) | Q08885 (RNH_BUCAP); |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Protein name | + RecName: EC=3.1.26.4; |
Comments
[?]
| CATALYTIC ACTIVITY | Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; |
Keywords
[?]
| Endonuclease | |
| Hydrolase | |
| Nuclease | |
| case <FTGroup:1> | |
| Magnesium | |
| Metal-binding | |
| end case | |
Gene Ontology
[?]
| GO:0004519; Molecular function:endonuclease activity | |
| GO:0016787; Molecular function:hydrolase activity | |
| GO:0004518; Molecular function:nuclease activity | |
| case <FTGroup:1> | |
| GO:0000287; Molecular function:magnesium ion binding | |
| end case | |
Features
[?]
| From: PS50879 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="RNase H type-1" | |||||||||
| case not <OC:Bacteria> and not <OC:Archaea> | ||||||||||||
| BINDING | 10 | 10 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#1" |
D | 1 | |||||||
| BINDING | 10 | 10 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#2" |
D | 1 | |||||||
| BINDING | 50 | 50 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#1" |
E | 1 | |||||||
| BINDING | 72 | 72 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#1" |
D | 1 | |||||||
| BINDING | 136 | 136 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#2" |
D | 1 | |||||||
| end case | ||||||||||||
Additional information
[?]
| Size range | 101-205 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]