General rule information
[?]
Accession |
PRU00408 |
Dates |
3-MAR-2005 (Created) 21-NOV-2019 (Last updated, Version 15) |
Predictors |
PROSITE; PS50879; RNASE_H
|
Name |
Ribonuclease H domain |
Function |
Ribonuclease H (RNase H) (EC 3.1.26.4) recognizes and cleaves the RNA strand of RNA-DNA heteroduplexes. |
Propagated annotation
[?]
Catalytic activity |
Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; |
GO:0004519; Molecular function: endonuclease activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0004518; Molecular function: nuclease activity.
case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
case <FTGroup:1>
end case
From: PS50879 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
RNase H
|
|
|
|
|
|
|
case not <OC:Bacteria> and not <OC:Archaea>
METAL
|
|
10
|
|
10
|
|
Magnesium
|
|
|
|
D
|
|
1
|
METAL
|
|
50
|
|
50
|
|
Magnesium
|
|
|
|
E
|
|
1
|
METAL
|
|
74
|
|
74
|
|
Magnesium
|
|
|
|
D
|
|
1
|
METAL
|
|
127
|
|
127
|
|
Magnesium
|
|
|
|
D
|
|
1
|
end case
Additional information
[?]
Size range |
101-205 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
Q08885 (RNH_BUCAP) |
Scope |
Eukaryota
Bacteria
Archaea
Viruses |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]