ProRule PRU00408

General rule information [?]

Accession PRU00408
Dates 3-MAR-2005 (Created)
19-NOV-2022 (Last updated, Version 19)
Data class Domain;
Predictors PROSITE; PS50879; RNASE_H_1
Name Ribonuclease H type-1 domain
Function Ribonuclease H (RNase H) (EC recognizes and cleaves the RNA strand of RNA-DNA heteroduplexes.
Scope(s) Eukaryota
Example(s) Q08885 (RNH_BUCAP);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=;

Comments [?]

CATALYTIC ACTIVITY Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=;

Keywords [?]

Gene Ontology [?]

GO:0004519; Molecular function:endonuclease activity
GO:0016787; Molecular function:hydrolase activity
GO:0004518; Molecular function:nuclease activity
case <FTGroup:1>
GO:0000287; Molecular function:magnesium ion binding
end case

Features [?]

From: PS50879
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="RNase H type-1"
case not <OC:Bacteria> and not <OC:Archaea>
BINDING 10 10 /ligand="Mg(2+)"
D 1
BINDING 10 10 /ligand="Mg(2+)"
D 1
BINDING 50 50 /ligand="Mg(2+)"
E 1
BINDING 72 72 /ligand="Mg(2+)"
D 1
BINDING 136 136 /ligand="Mg(2+)"
D 1
end case

Additional information [?]

Size range 101-205 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB rule member sequences [?]