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annotation rule: PRU00408

General rule information [?]

Accession PRU00408
Dates 3-MAR-2005 (Created)
27-OCT-2018 (Last updated, Version 14)
Data class Domain
Predictors PROSITE; PS50879; RNASE_H
Name Ribonuclease H domain
Function Ribonuclease H (RNase H) (EC 3.1.26.4) recognizes and cleaves the RNA strand of RNA-DNA heteroduplexes.

Propagated annotation [?]


Description [?]

+ RecName: EC=3.1.26.4;

Comments [?]

Catalytic activity Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;.

Gene Ontology [?]

GO:0004519; Molecular function: endonuclease activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0004518; Molecular function: nuclease activity.
case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case


Keywords [?]

Endonuclease
Hydrolase
Nuclease
case <FTGroup:1>
Magnesium
Metal-binding
end case


Features [?]

From: PS50879
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       RNase H        
case not <OC:Bacteria> and not <OC:Archaea>
METAL     10     10       Magnesium     D   1
METAL     50     50       Magnesium     E   1
METAL     74     74       Magnesium     D   1
METAL     127     127       Magnesium     D   1
end case


Additional information [?]

Size range 101-205 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q08885 (RNH_BUCAP)
Scope
Eukaryota
Bacteria
Archaea
Viruses

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]