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annotation rule: PRU00417

General rule information [?]

Accession PRU00417
Dates 6-APR-2005 (Created)
21-NOV-2019 (Last updated, Version 16)
Data class Domain
Predictors PROSITE; PS51094; PTS_EIIA_TYPE_2
Name PTS EIIA type-2 domain
Function Phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system.

Propagated annotation [?]

Comments [?]

case (<OC:Bacteria> or <OC:Archaea>) and <Feature:PS51094:61=H>
Domain The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.
end case

Gene Ontology [?]

case (<OC:Bacteria> or <OC:Archaea>) and <Feature:PS51094:61=H>
GO:0016740; Molecular function: transferase activity.

Keywords [?]

end case

Features [?]

From: PS51094
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       PTS EIIA type-2 #        
case <AnyFeature:PS51099:7=C> or <AnyFeature:PS51350:15=H>
ACT_SITE     61     61       Tele-phosphohistidine intermediate; for EIIA activity     H  
ACT_SITE     61     61       Tele-phosphohistidine intermediate     H  
end case

Additional information [?]

Warning This domain can be found in other kind of proteins, mainly transcriptional regulators, in these cases it may serve as a regulatory function, through its phosphorylation activity, or as a simple phosphoryl. Check DE, KW , FT and CC DOMAIN.
Size range 142 amino acids
Related rules none
Repeats 1
Topology Undefined
Example P44715 (PTFAH_HAEIN)


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UniProtKB rule member sequences [?]