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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00417


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00417
General rule information [?]

Accession PRU00417
Dates 06-APR-2005 (Created)
21-NOV-2019 (Last updated, Version 17)
Data class Domain;
Predictors PROSITE; PS51094; PTS_EIIA_TYPE_2
Name PTS EIIA type-2 domain
Function Phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system.
Scope(s) Bacteria
Archaea
Example(s) P44715;

Propagated annotation [?]

Comments [?]

case (<OC:Bacteria> or <OC:Archaea>) and <Feature:PS51094:61=H>
DOMAINThe PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.
end case

Keywords [?]

Phosphoprotein
Phosphotransferase system
Transferase
end case

Gene Ontology [?]

case (<OCellular component:Bacteria> or <OC:Archaea>) and <Feature:PS51094:61=H>
GO:0016740; Molecular function:transferase activity

Features [?]

From: PS51094
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PTS EIIA type-2 #"
case <AnyFeature:PS51099:7=C> or <AnyFeature:PS51350:15=H>
ACT_SITE 61 61 /note="Tele-phosphohistidine intermediate; for EIIA activity" H
else
ACT_SITE 61 61 /note="Tele-phosphohistidine intermediate" H
end case

Additional information [?]

Size range 142 amino acids
Related rules none
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]