We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00419
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00419
General rule information
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| Accession | PRU00419 |
| Dates | 06-APR-2005 (Created)
21-NOV-2019 (Last updated, Version 18) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51096; PTS_EIIA_TYPE_4 |
Name | PTS EIIA type-4 domain |
| Function | Phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system. |
| Scope(s) |
Bacteria Archaea |
| Example(s) | P26379; |
Propagated annotation
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Comments
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| case (<OC:Bacteria> or <OC:Archaea>) and <Feature:PS51096:9=H> | |
| DOMAIN | The EIIA type-4 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB type-4 domain. |
| end case | |
Keywords
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| Phosphotransferase system | |
| Transferase | |
| end case | |
| case <AnyFeature:PS51350:15=H> or <AnyFeature:PS51101:16=H> | |
Gene Ontology
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| case (<OCellular component:Bacteria> or <OC:Archaea>) and <Feature:PS51096:9=H> | |
| GO:0009401; Biological process:phosphoenolpyruvate-dependent sugar phosphotransferase system | |
| GO:0016740; Molecular function:transferase activity | |
Features
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| From: PS51096 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="PTS EIIA type-4 #" | |||||||||
| case <AnyFeature:PS51350:15=H> or <AnyFeature:PS51101:16=H> | ||||||||||||
| ACT_SITE | 9 | 9 | /note="Tele-phosphohistidine intermediate; for EIIA activity" | H | ||||||||
| else | ||||||||||||
| ACT_SITE | 9 | 9 | /note="Tele-phosphohistidine intermediate" | H | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 125 amino acids |
| Related rules |
none |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [18] All [ 18 ]
- Retrieve set of proteins with 3D structure for this domain