Home  |  Contact
annotation rule: PRU00419

General rule information [?]

Accession PRU00419
Dates 6-APR-2005 (Created)
21-NOV-2019 (Last updated, Version 17)
Data class Domain
Predictors PROSITE; PS51096; PTS_EIIA_TYPE_4
Name PTS EIIA type-4 domain
Function Phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system.

Propagated annotation [?]

Comments [?]

case (<OC:Bacteria> or <OC:Archaea>) and <Feature:PS51096:9=H>
Domain The EIIA type-4 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB type-4 domain.
end case

Gene Ontology [?]

case (<OC:Bacteria> or <OC:Archaea>) and <Feature:PS51096:9=H>
GO:0009401; Biological process: phosphoenolpyruvate-dependent sugar phosphotransferase system.
GO:0016740; Molecular function: transferase activity.

Keywords [?]

end case

Features [?]

From: PS51096
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       PTS EIIA type-4 #        
case <AnyFeature:PS51350:15=H> or <AnyFeature:PS51101:16=H>
ACT_SITE     9     9       Tele-phosphohistidine intermediate; for EIIA activity     H  
ACT_SITE     9     9       Tele-phosphohistidine intermediate     H  
end case

Additional information [?]

Warning This domain can be found in other kind of proteins, mainly transcriptional regulators, in these cases it may serve as a regulatory function, through its phosphorylation activity, or as a simple phosphoryl. Check DE, KW, FT and CC DOMAIN.
Size range 125 amino acids
Related rules none
Repeats 1
Topology Undefined
Example P26379 (PTFA_BACSU)


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]