We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00421
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00421
General rule information
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| Accession | PRU00421 |
| Dates | 06-APR-2005 (Created)
21-NOV-2019 (Last updated, Version 23) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51098; PTS_EIIB_TYPE_1 |
Name | PTS EIIB type-1 domain |
| Function | Phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system. |
| Scope(s) |
Bacteria Archaea |
| Example(s) | P69789; |
Propagated annotation
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Identifier, protein and gene names
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| case (<OC:Bacteria> or <OC:Archaea>) and <Feature:PS51098:23=C> | |
| Protein name | + RecName: EC=2.7.1.-; |
Comments
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| DOMAIN | The PTS EIIB type-1 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-1 domain. |
| end case | |
Keywords
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| Phosphotransferase system | |
| Transferase | |
| end case | |
Gene Ontology
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| case (<OCellular component:Bacteria> or <OC:Archaea>) and <Feature:PS51098:23=C> | |
| GO:0016740; Molecular function:transferase activity | |
Features
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| From: PS51098 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="PTS EIIB type-1 #" | |||||||||
| ACT_SITE | 23 | 23 | /note="Phosphocysteine intermediate; for EIIB activity" | C | ||||||||
Additional information
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| Size range | 82 amino acids |
| Related rules |
none |
| Fusion | None |
| Repeats | 1-2 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [110] All [ 110 ]
- Retrieve set of proteins with 3D structure for this domain