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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00436


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00436
General rule information [?]

Accession PRU00436
Dates 06-MAY-2005 (Created)
27-JUN-2022 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51080; CTF_NFI_2
Name CTF/NF-I DNA-binding domain
Function The CTF/NF-I DNA-binding domain contains four conserved Cys residues, which are required for its DNA-binding activity.
Scope(s) Eukaryota
Metazoa
Example(s) Q12857;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.
SIMILARITYBelongs to the CTF/NF-I family.

Keywords [?]

Activator
DNA-binding
DNA replication
Nucleus
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0006260; Biological process:DNA replication
GO:0005634; Cellular component:nucleus
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Cross-references [?]

PROSITE PS00349; CTF_NFI_1; 1;

Features [?]

From: PS51080
Key From To Description Tag Condition FTGroup
DNA_BIND from to /note="CTF/NF-I #"

Additional information [?]

Size range 190-195 amino acids
Related rules None
Fusion None
Repeats 1
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]