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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00450


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00450
General rule information [?]

Accession PRU00450
Dates 28-JUN-2005 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS50876; ZF_INTEGRASE
Name Zinc finger integrase-type
Function required for integration activity and enhances tetramerization in the context of the full-length integrase.
Scope(s) Eukaryota
Viruses
Example(s) P51517;

Propagated annotation [?]

Keywords [?]

Zinc-finger
case <Feature:PS50876:10=[CH]> and <Feature:PS50876:14=[CH]> and <Feature:PS50876:38=[CH]> and <Feature:PS50876:41=[CH]>
Zinc
Metal-binding
end case

Features [?]

From: PS50876
Key From To Description Tag Condition FTGroup
case <Feature:PS50876:10=[H]> and <Feature:PS50876:14=[H]> and <Feature:PS50876:38=[C]> and <Feature:PS50876:41=[C]>
ZN_FING from to /note="Integrase-type #"
else case <Feature:PS50876:10=[CH]> and <Feature:PS50876:14=[CH]> and <Feature:PS50876:38=[CH]> and <Feature:PS50876:41=[CH]>
ZN_FING from to /note="Integrase-type #; atypical"
else
ZN_FING from to /note="Integrase-type #; degenerate"
end case
BINDING 10 10 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 14 14 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 38 38 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 41 41 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 30-54 amino acids
Related rules None
Fusion None
Repeats 1-3
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]