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| Entry: PS50876 |
General information about the entry
| Entry name [info] | ZF_INTEGRASE |
| Accession [info] | PS50876 |
| Entry type [info] | MATRIX |
| Date [info] |
01-APR-2004 CREATED;
10-MAY-2017 DATA UPDATE; 10-FEB-2021 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC50876 |
| Associated ProRule [info] | PRU00450 |
Name and characterization of the entry
| Description [info] | Zinc finger integrase-type profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=42; /DISJOINT: DEFINITION=PROTECT; N1=5; N2=38; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3575423; R2=0.0122680; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2595.2043457; R2=0.6439499; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=501; H_SCORE=2918; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=338; H_SCORE=2813; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-8; D=-30; I=-30; B1=-300; E1=-300; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='E'; M= -7, 2,-26, 6, 16,-21, -9,-10,-24, -1,-17,-16, -2,-11, 2, -6, 1, -2,-20,-15,-13, 9; /M: SY='N'; M= 4, 6,-22, -2, -2,-22, -5, -8,-21, 7,-23,-14, 13, -6, -2, 5, 3, -1,-18,-27,-18, -3; /M: SY='I'; M= -9,-28,-24,-33,-25, 1,-34,-24, 32,-23, 24, 18,-22,-24,-18,-18,-21, -9, 23,-21, -2,-24; /M: SY='E'; M= -8, 9,-28, 16, 20,-29,-17, -5,-22, 2,-19,-15, 1, 0, 11, -2, -1, -6,-21,-29,-17, 14; /M: SY='E'; M= -3, -2,-29, 2, 22,-29,-17, -6,-24, 9,-23,-14, -4, 11, 14, 4, 0, -7,-24,-26,-18, 17; /M: SY='A'; M= 39,-11,-13,-18, -9,-20, -3,-20,-10,-10,-12,-11,-10, -2,-10,-19, 10, 1, -1,-23,-20,-10; /M: SY='Q'; M= -4, -7,-27, -7, 8,-26,-14, -6,-14, 5,-14, -4, -5,-13, 18, 7, -4, -9,-14,-22,-13, 12; /M: SY='E'; M= -9, 10,-28, 15, 35,-30,-17, 0,-24, 8,-21,-15, 5, -6, 20, 1, 2, -7,-25,-29,-17, 27; /M: SY='E'; M= -6, 7,-24, 9, 18,-19,-15, -4,-19, 1,-12,-13, 4,-12, 3, -4, 0, -5,-18,-27,-11, 11; /M: SY='H'; M=-18, -1,-29, 0, 4,-19,-20, 83,-26, -8,-17, 3, 7,-18, 10, -1,-10,-18,-27,-29, 15, 3; /M: SY='E'; M= 2, 2,-20, 2, 14,-17,-15, -5,-18, -3,-16,-14, -2,-10, 4, -8, 8, 7,-14,-22, -5, 8; /M: SY='K'; M=-11, -7,-25, -9, -1,-12,-22,-10,-16, 17, -9, -3, -4,-17, 2, 14,-10, -5,-13,-19, -6, 1; /M: SY='Y'; M=-16,-21,-30,-23,-17, 14,-25, 4, -8,-12, -1, -3,-19,-26,-12,-10,-21,-11,-12, 29, 32,-15; /M: SY='H'; M=-19, -3,-30, -4, -3,-18,-22, 88,-23,-12,-16, 2, 7,-20, 7, -3,-11,-19,-25,-29, 18, -3; /M: SY='T'; M= -1,-11,-16,-13, -8,-13,-13,-14, -4,-13, -3, -3, -8,-17, -2,-11, 7, 10, -1,-28,-12, -5; /M: SY='N'; M= -2, 23,-22, 15, -3,-24, 12, -3,-26, -6,-27,-20, 30,-17, -5, -8, 9, -2,-25,-34,-22, -4; /M: SY='A'; M= 15,-18,-19,-22,-16,-10,-12,-20, -4,-13, -9, -3,-17,-12,-13,-18, -1, -1, 2, 1, -9,-14; /M: SY='R'; M= -9, -4,-27, -5, 5,-21,-19, 9,-23, 18,-20, -7, -1,-14, 13, 19, -5, -6,-19,-18, 0, 7; /M: SY='A'; M= 9, -8,-21,-12, -4,-16, -5,-12,-12, -5,-14, -9, -5,-13, -3,-10, 4, 1, -8,-19, -8, -5; /M: SY='L'; M=-10,-23,-20,-26,-18, 7,-27,-16, 16,-26, 41, 18,-21,-29,-17,-18,-26, -9, 6,-22, -2,-18; /M: SY='S'; M= 7, -6, -7, -9, -1,-24,-11,-11,-22, 7,-22,-12, -2,-14, 4, 7, 8, 0,-13,-28,-17, 1; /M: SY='H'; M=-13, -4,-26, -3, 3,-14,-19, 6,-17, -3, -9, -7, -1, -8, 3, 5, -6, -6,-18,-25, -7, 1; /M: SY='E'; M= -8, 9,-25, 9, 22,-26,-16, -2,-23, 12,-21,-11, 7, -8, 14, 4, 3, -2,-22,-29,-15, 18; /M: SY='F'; M=-18,-28, 1,-37,-29, 56,-30,-19, -3,-29, 8, -2,-21,-32,-35,-21,-19,-10, -1, -1, 21,-29; /M: SY='N'; M= -7, 11,-26, 7, 0,-28, 10, 0,-29, 5,-29,-16, 17,-16, 3, 1, 3, -8,-26,-28,-18, 1; /M: SY='I'; M= -9,-30,-25,-35,-26, 4,-35,-26, 37,-29, 31, 19,-25,-25,-21,-25,-23, -9, 23,-21, -1,-26; /M: SY='P'; M= -8,-17,-36, -9, -1,-28,-19,-19,-19,-10,-29,-19,-17, 77, -9,-19, -5, -4,-27,-31,-28, -9; /M: SY='R'; M=-13, -6,-26,-10, -6,-13,-18, -6,-14, 4, -9, -3, 1,-15, 1, 16, -9, -4,-15,-13, -8, -4; /M: SY='L'; M= 0,-14,-19,-16, -5, -9,-22,-16, 0, -5, 6, 3,-15,-18, -8, -6, -8, 1, 4,-24, -9, -7; /M: SY='V'; M= 2,-19,-17,-20,-12,-12,-25,-19, 14,-12, 1, 5,-19,-21, -6,-14, -6, -4, 22,-26,-11, -9; /M: SY='A'; M= 46,-12,-10,-21,-12,-18, -2,-21, -7,-11, -8, -8,-12,-12,-12,-20, 8, 0, 4,-21,-19,-12; /M: SY='R'; M=-14, -2,-30, 0, 17,-26,-20, -3,-30, 32,-23,-12, 0,-12, 12, 41, -8,-10,-22,-22,-12, 12; /M: SY='Q'; M=-13, 10,-30, 16, 28,-35,-18, 4,-27, 11,-22,-12, 3, -9, 33, 12, -1,-10,-29,-26,-14, 30; /M: SY='I'; M= -9,-30,-28,-38,-29, 1,-38,-29, 46,-29, 22, 19,-22,-22,-21,-28,-20, -9, 30,-21, -1,-29; /M: SY='V'; M= -3,-27,-16,-30,-27, -1,-30,-29, 26,-18, 7, 8,-26,-26,-25,-19,-11, -1, 37,-20, -7,-27; /M: SY='Q'; M= -6, 7,-26, 3, 11,-27,-14, 5,-23, 14,-22,-10, 12,-13, 19, 16, 0, -7,-24,-26,-13, 14; /M: SY='S'; M= 0, -1,-19, -2, 7,-22,-13, 5,-21, 1,-21,-12, 3,-11, 9, 3, 13, 8,-16,-30,-11, 7; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='P'; M= 7, -3,-21, -1, 6,-25,-10,-13,-20, -7,-23,-17, -3, 15, 0,-12, 13, 5,-16,-31,-21, 1; /M: SY='H'; M= -9, -5,-26, -6, 3,-21,-21, 24,-15, 2,-13, -1, -1,-15, 12, 1, -5, -6,-15,-25, -1, 6; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='Q'; M= -6, -1,-26, -3, 10,-32,-18, 1,-17, 7,-19, -4, 1, -7, 34, 7, 0, -5,-21,-23,-12, 21; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 98 in 98 different sequences |
| Number of true positive hits | 98 in 98 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 6 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 94.23 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | N_Hulo |
| Taxonomic range [info] | Eukaryotes, Eukaryotic viruses |
| Maximum number of repetitions [info] | 1 |
| Feature key [info] | ZN_FING |
| Feature description [info] | Integrase-type |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
98 sequences
PO113_HUMAN (P63132 ), POK10_HUMAN (P10266 ), POK11_HUMAN (Q9UQG0 ), POK18_HUMAN (Q9QC07 ), POK19_HUMAN (Q9WJR5 ), POK25_HUMAN (P63136 ), POK6_HUMAN (Q9BXR3 ), POK7_HUMAN (P63135 ), POK8_HUMAN (P63133 ), POL1_CHICK (P10399 ), POL_ALV (Q7SQ98 ), POL_BIV29 (P19560 ), POL_CAEVC (P33459 ), POL_EIAV9 (P11204 ), POL_EIAVC (P32542 ), POL_EIAVY (P03371 ), POL_FIVPE (P16088 ), POL_FIVSD (P19028 ), POL_FIVT2 (P31822 ), POL_HV190 (O93215 ), POL_HV192 (O12158 ), POL_HV193 (O89290 ), POL_HV196 (Q9QBY3 ), POL_HV197 (Q9QBZ9 ), POL_HV19N (O41798 ), POL_HV1A2 (P03369 ), POL_HV1AN (Q77373 ), POL_HV1B1 (P03366 ), POL_HV1B5 (P04587 ), POL_HV1B9 (Q73368 ), POL_HV1BR (P03367 ), POL_HV1EL (P04589 ), POL_HV1ET (Q75002 ), POL_HV1H2 (P04585 ), POL_HV1JR (P20875 ), POL_HV1LW (P0C6F2 ), POL_HV1M2 (Q9QBZ1 ), POL_HV1MA (P04588 ), POL_HV1MN (P05961 ), POL_HV1MP (Q9QBZ5 ), POL_HV1MV (Q79666 ), POL_HV1N5 (P12497 ), POL_HV1ND (P18802 ), POL_HV1OY (P20892 ), POL_HV1RH (P05959 ), POL_HV1S2 (Q9WC54 ), POL_HV1S9 (Q9WC63 ), POL_HV1SE (O89940 ), POL_HV1U4 (P24740 ), POL_HV1V9 (Q9Q720 ), POL_HV1VI (Q9QSR3 ), POL_HV1Y2 (P35963 ), POL_HV1YB (Q9IDV9 ), POL_HV1YF (O91080 ), POL_HV1Z2 (P12499 ), POL_HV2BE (P18096 ), POL_HV2CA (P24107 ), POL_HV2D1 (P17757 ), POL_HV2D2 (P15833 ), POL_HV2EH (Q89928 ), POL_HV2G1 (P18042 ), POL_HV2KR (Q74120 ), POL_HV2NZ (P05962 ), POL_HV2RO (P04584 ), POL_HV2SB (P12451 ), POL_HV2ST (P20876 ), POL_HV2UC (Q76634 ), POL_IPHA (P04026 ), POL_IPMAI (P12894 ), POL_JEMBR (Q82851 ), POL_JSRV (P31623 ), POL_MMTVB (P03365 ), POL_MMTVC (P11283 ), POL_MPMV (P07572 ), POL_OMVVS (P16901 ), POL_RSVP (P03354 ), POL_RSVSA (Q04095 ), POL_RSVSB (O92956 ), POL_SIVCZ (P17283 ), POL_SIVEK (Q1A249 ), POL_SIVG1 (Q02836 ), POL_SIVGB (P22382 ), POL_SIVM1 (P05896 ), POL_SIVMB (Q1A267 ), POL_SIVMK (P05897 ), POL_SIVS4 (P12502 ), POL_SIVSP (P19505 ), POL_SIVTN (Q8AII1 ), POL_SIVV1 (P27973 ), POL_SIVVG (P27980 ), POL_SIVVT (P05895 ), POL_SMRVH (P03364 ), POL_SRV1 (P04025 ), POL_SRV2 (P51517 ), POL_VILV (P03370 ), POL_VILV1 (P23426 ), POL_VILV2 (P23427 ), POL_VILVK (P35956 )» more
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| UniProtKB/Swiss-Prot False negative sequences |
6 sequences
POL_HTL1A (P03362 ), POL_HTL1C (P14078 ), POL_HTL1L (P0C211 ), POL_HTL32 (Q0R5R2 ), POL_HTL3P (Q4U0X6 ), POL_HTLV2 (P03363 )» more |
| PDB [Detailed view] |
26 PDB
1E0E; 1K6Y; 1WJA; 1WJB; 1WJC; 1WJD; 1WJE; 1WJF; 3F9K; 3HPG; 3HPH; 3JCA; 4FW2; 5CZ2; 5EJK; 5M0Q; 5M0R; 5U1C; 6PUT; 6PUW; 6PUY; 6PUZ; 6U8Q; 6V3K; 6VDK; 6VRG » more |
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