We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS50876
View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS50876
Direct ScanProsite submission
General information about the entry
| Entry name [info] | ZF_INTEGRASE |
| Accession [info] | PS50876 |
| Entry type [info] | MATRIX |
| Date [info] |
01-APR-2004 CREATED;
10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC50876 |
| Associated ProRule [info] | PRU00450 |
Name and characterization of the entry
| Description [info] | Zinc finger integrase-type profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=42; /DISJOINT: DEFINITION=PROTECT; N1=5; N2=38; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3575423; R2=0.0122680; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2595.2043457; R2=0.6439499; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=501; H_SCORE=2918; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=338; H_SCORE=2813; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-8; D=-30; I=-30; B1=-300; E1=-300; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='E'; M= -7, 2,-26, 6, 16,-21, -9,-10,-24, -1,-17,-16, -2,-11, 2, -6, 1, -2,-20,-15,-13, 9; /M: SY='N'; M= 4, 6,-22, -2, -2,-22, -5, -8,-21, 7,-23,-14, 13, -6, -2, 5, 3, -1,-18,-27,-18, -3; /M: SY='I'; M= -9,-28,-24,-33,-25, 1,-34,-24, 32,-23, 24, 18,-22,-24,-18,-18,-21, -9, 23,-21, -2,-24; /M: SY='E'; M= -8, 9,-28, 16, 20,-29,-17, -5,-22, 2,-19,-15, 1, 0, 11, -2, -1, -6,-21,-29,-17, 14; /M: SY='E'; M= -3, -2,-29, 2, 22,-29,-17, -6,-24, 9,-23,-14, -4, 11, 14, 4, 0, -7,-24,-26,-18, 17; /M: SY='A'; M= 39,-11,-13,-18, -9,-20, -3,-20,-10,-10,-12,-11,-10, -2,-10,-19, 10, 1, -1,-23,-20,-10; /M: SY='Q'; M= -4, -7,-27, -7, 8,-26,-14, -6,-14, 5,-14, -4, -5,-13, 18, 7, -4, -9,-14,-22,-13, 12; /M: SY='E'; M= -9, 10,-28, 15, 35,-30,-17, 0,-24, 8,-21,-15, 5, -6, 20, 1, 2, -7,-25,-29,-17, 27; /M: SY='E'; M= -6, 7,-24, 9, 18,-19,-15, -4,-19, 1,-12,-13, 4,-12, 3, -4, 0, -5,-18,-27,-11, 11; /M: SY='H'; M=-18, -1,-29, 0, 4,-19,-20, 83,-26, -8,-17, 3, 7,-18, 10, -1,-10,-18,-27,-29, 15, 3; /M: SY='E'; M= 2, 2,-20, 2, 14,-17,-15, -5,-18, -3,-16,-14, -2,-10, 4, -8, 8, 7,-14,-22, -5, 8; /M: SY='K'; M=-11, -7,-25, -9, -1,-12,-22,-10,-16, 17, -9, -3, -4,-17, 2, 14,-10, -5,-13,-19, -6, 1; /M: SY='Y'; M=-16,-21,-30,-23,-17, 14,-25, 4, -8,-12, -1, -3,-19,-26,-12,-10,-21,-11,-12, 29, 32,-15; /M: SY='H'; M=-19, -3,-30, -4, -3,-18,-22, 88,-23,-12,-16, 2, 7,-20, 7, -3,-11,-19,-25,-29, 18, -3; /M: SY='T'; M= -1,-11,-16,-13, -8,-13,-13,-14, -4,-13, -3, -3, -8,-17, -2,-11, 7, 10, -1,-28,-12, -5; /M: SY='N'; M= -2, 23,-22, 15, -3,-24, 12, -3,-26, -6,-27,-20, 30,-17, -5, -8, 9, -2,-25,-34,-22, -4; /M: SY='A'; M= 15,-18,-19,-22,-16,-10,-12,-20, -4,-13, -9, -3,-17,-12,-13,-18, -1, -1, 2, 1, -9,-14; /M: SY='R'; M= -9, -4,-27, -5, 5,-21,-19, 9,-23, 18,-20, -7, -1,-14, 13, 19, -5, -6,-19,-18, 0, 7; /M: SY='A'; M= 9, -8,-21,-12, -4,-16, -5,-12,-12, -5,-14, -9, -5,-13, -3,-10, 4, 1, -8,-19, -8, -5; /M: SY='L'; M=-10,-23,-20,-26,-18, 7,-27,-16, 16,-26, 41, 18,-21,-29,-17,-18,-26, -9, 6,-22, -2,-18; /M: SY='S'; M= 7, -6, -7, -9, -1,-24,-11,-11,-22, 7,-22,-12, -2,-14, 4, 7, 8, 0,-13,-28,-17, 1; /M: SY='H'; M=-13, -4,-26, -3, 3,-14,-19, 6,-17, -3, -9, -7, -1, -8, 3, 5, -6, -6,-18,-25, -7, 1; /M: SY='E'; M= -8, 9,-25, 9, 22,-26,-16, -2,-23, 12,-21,-11, 7, -8, 14, 4, 3, -2,-22,-29,-15, 18; /M: SY='F'; M=-18,-28, 1,-37,-29, 56,-30,-19, -3,-29, 8, -2,-21,-32,-35,-21,-19,-10, -1, -1, 21,-29; /M: SY='N'; M= -7, 11,-26, 7, 0,-28, 10, 0,-29, 5,-29,-16, 17,-16, 3, 1, 3, -8,-26,-28,-18, 1; /M: SY='I'; M= -9,-30,-25,-35,-26, 4,-35,-26, 37,-29, 31, 19,-25,-25,-21,-25,-23, -9, 23,-21, -1,-26; /M: SY='P'; M= -8,-17,-36, -9, -1,-28,-19,-19,-19,-10,-29,-19,-17, 77, -9,-19, -5, -4,-27,-31,-28, -9; /M: SY='R'; M=-13, -6,-26,-10, -6,-13,-18, -6,-14, 4, -9, -3, 1,-15, 1, 16, -9, -4,-15,-13, -8, -4; /M: SY='L'; M= 0,-14,-19,-16, -5, -9,-22,-16, 0, -5, 6, 3,-15,-18, -8, -6, -8, 1, 4,-24, -9, -7; /M: SY='V'; M= 2,-19,-17,-20,-12,-12,-25,-19, 14,-12, 1, 5,-19,-21, -6,-14, -6, -4, 22,-26,-11, -9; /M: SY='A'; M= 46,-12,-10,-21,-12,-18, -2,-21, -7,-11, -8, -8,-12,-12,-12,-20, 8, 0, 4,-21,-19,-12; /M: SY='R'; M=-14, -2,-30, 0, 17,-26,-20, -3,-30, 32,-23,-12, 0,-12, 12, 41, -8,-10,-22,-22,-12, 12; /M: SY='Q'; M=-13, 10,-30, 16, 28,-35,-18, 4,-27, 11,-22,-12, 3, -9, 33, 12, -1,-10,-29,-26,-14, 30; /M: SY='I'; M= -9,-30,-28,-38,-29, 1,-38,-29, 46,-29, 22, 19,-22,-22,-21,-28,-20, -9, 30,-21, -1,-29; /M: SY='V'; M= -3,-27,-16,-30,-27, -1,-30,-29, 26,-18, 7, 8,-26,-26,-25,-19,-11, -1, 37,-20, -7,-27; /M: SY='Q'; M= -6, 7,-26, 3, 11,-27,-14, 5,-23, 14,-22,-10, 12,-13, 19, 16, 0, -7,-24,-26,-13, 14; /M: SY='S'; M= 0, -1,-19, -2, 7,-22,-13, 5,-21, 1,-21,-12, 3,-11, 9, 3, 13, 8,-16,-30,-11, 7; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='P'; M= 7, -3,-21, -1, 6,-25,-10,-13,-20, -7,-23,-17, -3, 15, 0,-12, 13, 5,-16,-31,-21, 1; /M: SY='H'; M= -9, -5,-26, -6, 3,-21,-21, 24,-15, 2,-13, -1, -1,-15, 12, 1, -5, -6,-15,-25, -1, 6; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='Q'; M= -6, -1,-26, -3, 10,-32,-18, 1,-17, 7,-19, -4, 1, -7, 34, 7, 0, -5,-21,-23,-12, 21; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 98 in 98 different sequences |
| Number of true positive hits | 98 in 98 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 6 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 94.23 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes, Eukaryotic viruses |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | N_Hulo |
| Feature key [info] | ZN_FING |
| Feature description [info] | Integrase-type |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
98 sequences
PO113_HUMAN (P63132), POK10_HUMAN (P10266), POK11_HUMAN (Q9UQG0), POK18_HUMAN (Q9QC07), POK19_HUMAN (Q9WJR5), POK25_HUMAN (P63136), POK6_HUMAN (Q9BXR3), POK7_HUMAN (P63135), POK8_HUMAN (P63133), POL1_CHICK (P10399), POL_ALV (Q7SQ98), POL_ALVA(Q04095), POL_BIV29 (P19560), POL_CAEVC (P33459), POL_EIAV9 (P11204), POL_EIAVC (P32542), POL_EIAVY (P03371), POL_FIVPE (P16088), POL_FIVSD (P19028), POL_FIVT2 (P31822), POL_HV190 (O93215), POL_HV192 (O12158), POL_HV193 (O89290), POL_HV196 (Q9QBY3), POL_HV197 (Q9QBZ9), POL_HV19N (O41798), POL_HV1A2 (P03369), POL_HV1AN (Q77373), POL_HV1B1 (P03366), POL_HV1B5 (P04587), POL_HV1B9 (Q73368), POL_HV1BR (P03367), POL_HV1EL (P04589), POL_HV1ET (Q75002), POL_HV1H2 (P04585), POL_HV1JR (P20875), POL_HV1LW (P0C6F2), POL_HV1M2 (Q9QBZ1), POL_HV1MA (P04588), POL_HV1MN (P05961), POL_HV1MP (Q9QBZ5), POL_HV1MV (Q79666), POL_HV1N5 (P12497), POL_HV1ND (P18802), POL_HV1OY (P20892), POL_HV1RH (P05959), POL_HV1S2 (Q9WC54), POL_HV1S9 (Q9WC63), POL_HV1SE (O89940), POL_HV1U4 (P24740), POL_HV1V9 (Q9Q720), POL_HV1VI (Q9QSR3), POL_HV1Y2 (P35963), POL_HV1YB (Q9IDV9), POL_HV1YF (O91080), POL_HV1Z2 (P12499), POL_HV2BE (P18096), POL_HV2CA (P24107), POL_HV2D1 (P17757), POL_HV2D2 (P15833), POL_HV2EH (Q89928), POL_HV2G1 (P18042), POL_HV2KR (Q74120), POL_HV2NZ (P05962), POL_HV2RO (P04584), POL_HV2SB (P12451), POL_HV2ST (P20876), POL_HV2UC (Q76634), POL_IPHA(P04026), POL_IPMAI (P12894), POL_JEMBR (Q82851), POL_JSRV(P31623), POL_MMTVB (P03365), POL_MMTVC (P11283), POL_MPMV(P07572), POL_OMVVS (P16901), POL_RSVP(P03354), POL_RSVSB (O92956), POL_SIVCZ (P17283), POL_SIVEK (Q1A249), POL_SIVG1 (Q02836), POL_SIVGB (P22382), POL_SIVM1 (P05896), POL_SIVM2 (P05897), POL_SIVMB (Q1A267), POL_SIVS4 (P12502), POL_SIVSP (P19505), POL_SIVTN (Q8AII1), POL_SIVV1 (P27973), POL_SIVVG (P27980), POL_SIVVT (P05895), POL_SMRVH (P03364), POL_SRV1(P04025), POL_SRV2(P51517), POL_VILV(P03370), POL_VILV1 (P23426), POL_VILV2 (P23427), POL_VILVK (P35956)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
6 sequences
POL_HTL1A (P03362), POL_HTL1C (P14078), POL_HTL1L (P0C211), POL_HTL32 (Q0R5R2), POL_HTL3P (Q4U0X6), POL_HTLV2 (P03363)» more |
| PDB [Detailed view] |
50 PDB
pdb_00001e0e; pdb_00001k6y; pdb_00001wja; pdb_00001wjb; pdb_00001wjc; pdb_00001wjd; pdb_00001wje; pdb_00001wjf; pdb_00003f9k; pdb_00003hpg; pdb_00003hph; pdb_00003jca; pdb_00004fw2; pdb_00005cz2; pdb_00005ejk; pdb_00005m0r; pdb_00005u1c; pdb_00006put; pdb_00006puw; pdb_00006puy; pdb_00006puz; pdb_00006u8q; pdb_00006v3k; pdb_00006vdk; pdb_00006vrg; pdb_00007jn3; pdb_00007ku7; pdb_00007kui; pdb_00007sep; pdb_00007sjx; pdb_00007u32; pdb_00007usf; pdb_00007ut1; pdb_00007z1z; pdb_00007zpp; pdb_00008e14; pdb_00008fn7; pdb_00008fnd; pdb_00008fng; pdb_00008fnh; pdb_00008fnj; pdb_00008fnl; pdb_00008fnm; pdb_00008fnn; pdb_00008fno; pdb_00008fnp; pdb_00008fnq; pdb_00008w09; pdb_00008w2r; pdb_00008w34 » more |