PROSITE entry PS50876

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General information about the entry

Entry name [info]	ZF_INTEGRASE
Accession [info]	PS50876
Entry type [info]	MATRIX
Date [info]	01-APR-2004 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50876
Associated ProRule [info]	PRU00450

Name and characterization of the entry

Description [info]

Zinc finger integrase-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=42;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=38;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3575423; R2=0.0122680; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2595.2043457; R2=0.6439499; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=501; H_SCORE=2918; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=338; H_SCORE=2813; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-30; I=-30; B1=-300; E1=-300; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='E';  M= -7,  2,-26,  6, 16,-21, -9,-10,-24, -1,-17,-16, -2,-11,  2, -6,  1, -2,-20,-15,-13,  9;
/M: SY='N';  M=  4,  6,-22, -2, -2,-22, -5, -8,-21,  7,-23,-14, 13, -6, -2,  5,  3, -1,-18,-27,-18, -3;
/M: SY='I';  M= -9,-28,-24,-33,-25,  1,-34,-24, 32,-23, 24, 18,-22,-24,-18,-18,-21, -9, 23,-21, -2,-24;
/M: SY='E';  M= -8,  9,-28, 16, 20,-29,-17, -5,-22,  2,-19,-15,  1,  0, 11, -2, -1, -6,-21,-29,-17, 14;
/M: SY='E';  M= -3, -2,-29,  2, 22,-29,-17, -6,-24,  9,-23,-14, -4, 11, 14,  4,  0, -7,-24,-26,-18, 17;
/M: SY='A';  M= 39,-11,-13,-18, -9,-20, -3,-20,-10,-10,-12,-11,-10, -2,-10,-19, 10,  1, -1,-23,-20,-10;
/M: SY='Q';  M= -4, -7,-27, -7,  8,-26,-14, -6,-14,  5,-14, -4, -5,-13, 18,  7, -4, -9,-14,-22,-13, 12;
/M: SY='E';  M= -9, 10,-28, 15, 35,-30,-17,  0,-24,  8,-21,-15,  5, -6, 20,  1,  2, -7,-25,-29,-17, 27;
/M: SY='E';  M= -6,  7,-24,  9, 18,-19,-15, -4,-19,  1,-12,-13,  4,-12,  3, -4,  0, -5,-18,-27,-11, 11;
/M: SY='H';  M=-18, -1,-29,  0,  4,-19,-20, 83,-26, -8,-17,  3,  7,-18, 10, -1,-10,-18,-27,-29, 15,  3;
/M: SY='E';  M=  2,  2,-20,  2, 14,-17,-15, -5,-18, -3,-16,-14, -2,-10,  4, -8,  8,  7,-14,-22, -5,  8;
/M: SY='K';  M=-11, -7,-25, -9, -1,-12,-22,-10,-16, 17, -9, -3, -4,-17,  2, 14,-10, -5,-13,-19, -6,  1;
/M: SY='Y';  M=-16,-21,-30,-23,-17, 14,-25,  4, -8,-12, -1, -3,-19,-26,-12,-10,-21,-11,-12, 29, 32,-15;
/M: SY='H';  M=-19, -3,-30, -4, -3,-18,-22, 88,-23,-12,-16,  2,  7,-20,  7, -3,-11,-19,-25,-29, 18, -3;
/M: SY='T';  M= -1,-11,-16,-13, -8,-13,-13,-14, -4,-13, -3, -3, -8,-17, -2,-11,  7, 10, -1,-28,-12, -5;
/M: SY='N';  M= -2, 23,-22, 15, -3,-24, 12, -3,-26, -6,-27,-20, 30,-17, -5, -8,  9, -2,-25,-34,-22, -4;
/M: SY='A';  M= 15,-18,-19,-22,-16,-10,-12,-20, -4,-13, -9, -3,-17,-12,-13,-18, -1, -1,  2,  1, -9,-14;
/M: SY='R';  M= -9, -4,-27, -5,  5,-21,-19,  9,-23, 18,-20, -7, -1,-14, 13, 19, -5, -6,-19,-18,  0,  7;
/M: SY='A';  M=  9, -8,-21,-12, -4,-16, -5,-12,-12, -5,-14, -9, -5,-13, -3,-10,  4,  1, -8,-19, -8, -5;
/M: SY='L';  M=-10,-23,-20,-26,-18,  7,-27,-16, 16,-26, 41, 18,-21,-29,-17,-18,-26, -9,  6,-22, -2,-18;
/M: SY='S';  M=  7, -6, -7, -9, -1,-24,-11,-11,-22,  7,-22,-12, -2,-14,  4,  7,  8,  0,-13,-28,-17,  1;
/M: SY='H';  M=-13, -4,-26, -3,  3,-14,-19,  6,-17, -3, -9, -7, -1, -8,  3,  5, -6, -6,-18,-25, -7,  1;
/M: SY='E';  M= -8,  9,-25,  9, 22,-26,-16, -2,-23, 12,-21,-11,  7, -8, 14,  4,  3, -2,-22,-29,-15, 18;
/M: SY='F';  M=-18,-28,  1,-37,-29, 56,-30,-19, -3,-29,  8, -2,-21,-32,-35,-21,-19,-10, -1, -1, 21,-29;
/M: SY='N';  M= -7, 11,-26,  7,  0,-28, 10,  0,-29,  5,-29,-16, 17,-16,  3,  1,  3, -8,-26,-28,-18,  1;
/M: SY='I';  M= -9,-30,-25,-35,-26,  4,-35,-26, 37,-29, 31, 19,-25,-25,-21,-25,-23, -9, 23,-21, -1,-26;
/M: SY='P';  M= -8,-17,-36, -9, -1,-28,-19,-19,-19,-10,-29,-19,-17, 77, -9,-19, -5, -4,-27,-31,-28, -9;
/M: SY='R';  M=-13, -6,-26,-10, -6,-13,-18, -6,-14,  4, -9, -3,  1,-15,  1, 16, -9, -4,-15,-13, -8, -4;
/M: SY='L';  M=  0,-14,-19,-16, -5, -9,-22,-16,  0, -5,  6,  3,-15,-18, -8, -6, -8,  1,  4,-24, -9, -7;
/M: SY='V';  M=  2,-19,-17,-20,-12,-12,-25,-19, 14,-12,  1,  5,-19,-21, -6,-14, -6, -4, 22,-26,-11, -9;
/M: SY='A';  M= 46,-12,-10,-21,-12,-18, -2,-21, -7,-11, -8, -8,-12,-12,-12,-20,  8,  0,  4,-21,-19,-12;
/M: SY='R';  M=-14, -2,-30,  0, 17,-26,-20, -3,-30, 32,-23,-12,  0,-12, 12, 41, -8,-10,-22,-22,-12, 12;
/M: SY='Q';  M=-13, 10,-30, 16, 28,-35,-18,  4,-27, 11,-22,-12,  3, -9, 33, 12, -1,-10,-29,-26,-14, 30;
/M: SY='I';  M= -9,-30,-28,-38,-29,  1,-38,-29, 46,-29, 22, 19,-22,-22,-21,-28,-20, -9, 30,-21, -1,-29;
/M: SY='V';  M= -3,-27,-16,-30,-27, -1,-30,-29, 26,-18,  7,  8,-26,-26,-25,-19,-11, -1, 37,-20, -7,-27;
/M: SY='Q';  M= -6,  7,-26,  3, 11,-27,-14,  5,-23, 14,-22,-10, 12,-13, 19, 16,  0, -7,-24,-26,-13, 14;
/M: SY='S';  M=  0, -1,-19, -2,  7,-22,-13,  5,-21,  1,-21,-12,  3,-11,  9,  3, 13,  8,-16,-30,-11,  7;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='P';  M=  7, -3,-21, -1,  6,-25,-10,-13,-20, -7,-23,-17, -3, 15,  0,-12, 13,  5,-16,-31,-21,  1;
/M: SY='H';  M= -9, -5,-26, -6,  3,-21,-21, 24,-15,  2,-13, -1, -1,-15, 12,  1, -5, -6,-15,-25, -1,  6;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Q';  M= -6, -1,-26, -3, 10,-32,-18,  1,-17,  7,-19, -4,  1, -7, 34,  7,  0, -5,-21,-23,-12, 21;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.

Total number of hits	98 in 98 different sequences
Number of true positive hits	98 in 98 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	6
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	94.23 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	N_Hulo
Feature key [info]	ZN_FING
Feature description [info]	Integrase-type
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

98 sequences

PO113_HUMAN (P63132), POK10_HUMAN (P10266), POK11_HUMAN (Q9UQG0),

POK18_HUMAN (Q9QC07), POK19_HUMAN (Q9WJR5), POK25_HUMAN (P63136), 
POK6_HUMAN  (Q9BXR3), POK7_HUMAN  (P63135), POK8_HUMAN  (P63133), 
POL1_CHICK  (P10399), POL_ALV (Q7SQ98), POL_ALVA(Q04095), 
POL_BIV29   (P19560), POL_CAEVC   (P33459), POL_EIAV9   (P11204), 
POL_EIAVC   (P32542), POL_EIAVY   (P03371), POL_FIVPE   (P16088), 
POL_FIVSD   (P19028), POL_FIVT2   (P31822), POL_HV190   (O93215), 
POL_HV192   (O12158), POL_HV193   (O89290), POL_HV196   (Q9QBY3), 
POL_HV197   (Q9QBZ9), POL_HV19N   (O41798), POL_HV1A2   (P03369), 
POL_HV1AN   (Q77373), POL_HV1B1   (P03366), POL_HV1B5   (P04587), 
POL_HV1B9   (Q73368), POL_HV1BR   (P03367), POL_HV1EL   (P04589), 
POL_HV1ET   (Q75002), POL_HV1H2   (P04585), POL_HV1JR   (P20875), 
POL_HV1LW   (P0C6F2), POL_HV1M2   (Q9QBZ1), POL_HV1MA   (P04588), 
POL_HV1MN   (P05961), POL_HV1MP   (Q9QBZ5), POL_HV1MV   (Q79666), 
POL_HV1N5   (P12497), POL_HV1ND   (P18802), POL_HV1OY   (P20892), 
POL_HV1RH   (P05959), POL_HV1S2   (Q9WC54), POL_HV1S9   (Q9WC63), 
POL_HV1SE   (O89940), POL_HV1U4   (P24740), POL_HV1V9   (Q9Q720), 
POL_HV1VI   (Q9QSR3), POL_HV1Y2   (P35963), POL_HV1YB   (Q9IDV9), 
POL_HV1YF   (O91080), POL_HV1Z2   (P12499), POL_HV2BE   (P18096), 
POL_HV2CA   (P24107), POL_HV2D1   (P17757), POL_HV2D2   (P15833), 
POL_HV2EH   (Q89928), POL_HV2G1   (P18042), POL_HV2KR   (Q74120), 
POL_HV2NZ   (P05962), POL_HV2RO   (P04584), POL_HV2SB   (P12451), 
POL_HV2ST   (P20876), POL_HV2UC   (Q76634), POL_IPHA(P04026), 
POL_IPMAI   (P12894), POL_JEMBR   (Q82851), POL_JSRV(P31623), 
POL_MMTVB   (P03365), POL_MMTVC   (P11283), POL_MPMV(P07572), 
POL_OMVVS   (P16901), POL_RSVP(P03354), POL_RSVSB   (O92956), 
POL_SIVCZ   (P17283), POL_SIVEK   (Q1A249), POL_SIVG1   (Q02836), 
POL_SIVGB   (P22382), POL_SIVM1   (P05896), POL_SIVMB   (Q1A267), 
POL_SIVMK   (P05897), POL_SIVS4   (P12502), POL_SIVSP   (P19505), 
POL_SIVTN   (Q8AII1), POL_SIVV1   (P27973), POL_SIVVG   (P27980), 
POL_SIVVT   (P05895), POL_SMRVH   (P03364), POL_SRV1(P04025), 
POL_SRV2(P51517), POL_VILV(P03370), POL_VILV1   (P23426), 
POL_VILV2   (P23427), POL_VILVK   (P35956)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

6 sequences

POL_HTL1A   (P03362), POL_HTL1C   (P14078), POL_HTL1L   (P0C211),

POL_HTL32   (Q0R5R2), POL_HTL3P   (Q4U0X6), POL_HTLV2   (P03363)

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PDB
[Detailed view]

47 PDB

1E0E; 1K6Y; 1WJA; 1WJB; 1WJC; 1WJD; 1WJE; 1WJF; 3F9K; 3HPG; 3HPH; 3JCA; 4FW2; 5CZ2; 5EJK; 5M0R; 5U1C; 6PUT; 6PUW; 6PUY; 6PUZ; 6U8Q; 6V3K; 6VDK; 6VRG; 7JN3; 7KU7; 7KUI; 7SEP; 7SJX; 7U32; 7USF; 7UT1; 7Z1Z; 7ZPP; 8E14; 8FN7; 8FND; 8FNG; 8FNH; 8FNJ; 8FNL; 8FNM; 8FNN; 8FNO; 8FNP; 8FNQ
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