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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00451


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00451
General rule information [?]

Accession PRU00451
Dates 28-JUN-2005 (Created)
19-NOV-2022 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51036; ZF_A20
Name Zinc finger A20-type
Function Functions as a ubiquitin ligase by polyubiquitinating RIP with Lys- 48-linked ubiquitin chains.
Scope(s) Eukaryota
Mammalia
Example(s) P21580;

Propagated annotation [?]

Keywords [?]

Zinc-finger
case <Feature:PS51036:7=[CH]> and <Feature:PS51036:11=[CH]> and <Feature:PS51036:23=[CH]> and <Feature:PS51036:26=[CH]>
Zinc
Metal-binding
end case

Features [?]

From: PS51036
Key From To Description Tag Condition FTGroup
case <Feature:PS51036:7=[C]> and <Feature:PS51036:11=[C]> and <Feature:PS51036:23=[C]> and <Feature:PS51036:26=[C]>
ZN_FING from to /note="A20-type #"
else case <Feature:PS51036:7=[CH]> and <Feature:PS51036:11=[CH]> and <Feature:PS51036:23=[CH]> and <Feature:PS51036:26=[CH]>
ZN_FING from to /note="A20-type #. atypical"
else
ZN_FING from to /note="A20-type #; degenerate"
end case
BINDING 7 7 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 11 11 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 26 26 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 32-34 amino acids
Related rules None
Fusion None
Repeats 1-7
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]