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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00452


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00452
General rule information [?]

Accession PRU00452
Dates 28-JUN-2005 (Created)
19-NOV-2022 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS51044; ZF_SP_RING
Name Zinc finger SP-RING-type
Function Like classical RING fingers SP-RINGs function as an E3 enzyme but specific for sumoylation.
Scope(s) Eukaryota
Example(s) O54714;

Propagated annotation [?]

Keywords [?]

Zinc-finger
case <Feature:PS51044:32=[CH]> and <Feature:PS51044:34=[HC]> and <Feature:PS51044:55=[CH]> and <Feature:PS51044:58=[CH]>
Zinc
Metal-binding
end case

Features [?]

From: PS51044
Key From To Description Tag Condition FTGroup
case <Feature:PS51044:32=[C]> and <Feature:PS51044:34=[H]> and <Feature:PS51044:55=[C]> and <Feature:PS51044:58=[C]>
ZN_FING from to /note="SP-RING-type #"
else case <Feature:PS51044:32=[CH]> and <Feature:PS51044:34=[HC]> and <Feature:PS51044:55=[CH]> and <Feature:PS51044:58=[CH]>
ZN_FING from to /note="SP-RING-type #; atypical"
else
ZN_FING from to /note="SP-RING-type #; degenerate"
end case
BINDING 32 32 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 34 34 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 55 55 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 58 58 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 60-85 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]