PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00453


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00453
General rule information [?]

Accession PRU00453
Dates 28-JUN-2005 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS51083; ZF_HIT
Name Zinc finger HIT-type
Function Undefined
Scope(s) Eukaryota
Example(s) P38772;

Propagated annotation [?]

Keywords [?]

Zinc-finger
case (<Feature:PS51083:1=[CH]> and <Feature:PS51083:4=[CH]> and <Feature:PS51083:21=[CH]> and <Feature:PS51083:25=[CH]>) or (<Feature:PS51083:13=[CH]> and <Feature:PS51083:16=[CH]> and <Feature:PS51083:29=[CH]> and <Feature:PS51083:34=[CH]>)
Zinc
Metal-binding
end case

Gene Ontology [?]

GO:0008270; Molecular function:zinc ion binding

Features [?]

From: PS51083
Key From To Description Tag Condition FTGroup
case (<Feature:PS51083:1=C> and <Feature:PS51083:4=C> and <Feature:PS51083:21=C> and <Feature:PS51083:25=C>) and (<Feature:PS51083:13=C> and <Feature:PS51083:16=C> and <Feature:PS51083:29=H> and <Feature:PS51083:34=C>)
ZN_FING from to /note="HIT-type #"
else case (<Feature:PS51083:1=[CH]> and <Feature:PS51083:4=[CH]> and <Feature:PS51083:21=[CH]> and <Feature:PS51083:25=[CH]>) and (<Feature:PS51083:13=[CH]> and <Feature:PS51083:16=[CH]> and <Feature:PS51083:29=[CH]> and <Feature:PS51083:34=[CH]>)
ZN_FING from to /note="HIT-type #; atypical"
else
ZN_FING from to /note="HIT-type #; degenerate"
end case
BINDING 1 1 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 4 4 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 13 13 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 16 16 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 21 21 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 25 25 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 29 29 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 34 34 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2

Additional information [?]

Size range 26-40 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]