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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00455


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00455
General rule information [?]

Accession PRU00455
Dates 29-JUN-2005 (Created)
19-NOV-2022 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51081; ZF_SIAH
Name Zinc finger SIAH-type
Function substrate- and cofactor-interaction domain
Scope(s) Eukaryota
Example(s) Q8R4T2;

Propagated annotation [?]

Keywords [?]

Zinc-finger
case (<Feature:PS50089:6=[CH]> and <Feature:PS50089:13=[CH]> and <Feature:PS50089:25=[CH]> and <Feature:PS50089:29=[CH]>) or (<Feature:PS50089:36=[CH]> and <Feature:PS50089:43=[CH]> and <Feature:PS50089:55=[CH]> and <Feature:PS50089:60=[CH]>)
Zinc
Metal-binding
end case
case <Feature:PS50089:6=[C]> and <Feature:PS50089:13=[C]> and <Feature:PS50089:25=[H]> and <Feature:PS50089:29=[C]> and <Feature:PS50089:36=[C]> and <Feature:PS50089:43=[C]> and <Feature:PS50089:55=[H]> and <Feature:PS50089:60=[H]>
else case <Feature:PS50089:6=[CH]> and <Feature:PS50089:13=[CH]> and <Feature:PS50089:25=[CH]> and <Feature:PS50089:29=[CH]> and <Feature:PS50089:36=[CH]> and <Feature:PS50089:43=[CH]> and <Feature:PS50089:55=[CH]> and <Feature:PS50089:60=[CH]>

Features [?]

From: PS51081
Key From To Description Tag Condition FTGroup
case <Feature:PS50089:6=[C]> and <Feature:PS50089:13=[C]> and <Feature:PS50089:25=[H]> and <Feature:PS50089:29=[C]> and <Feature:PS50089:36=[C]> and <Feature:PS50089:43=[C]> and <Feature:PS50089:55=[H]> and <Feature:PS50089:60=[H]>
ZN_FING from to /note="SIAH-type #"
else case <Feature:PS50089:6=[CH]> and <Feature:PS50089:13=[CH]> and <Feature:PS50089:25=[CH]> and <Feature:PS50089:29=[CH]> and <Feature:PS50089:36=[CH]> and <Feature:PS50089:43=[CH]> and <Feature:PS50089:55=[CH]> and <Feature:PS50089:60=[CH]>
ZN_FING from to /note="SIAH-type #; atypical"
else
ZN_FING from to /note="SIAH-type #; degenerate"
end case
BINDING 6 6 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 13 13 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 25 25 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 29 29 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 36 36 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 43 43 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 55 55 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 60 60 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2

Additional information [?]

Size range 50-70 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]