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annotation rule: PRU00456

General rule information [?]

Accession PRU00456
Dates 29-JUN-2005 (Created)
14-MAY-2022 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS51074; DPH_MB
Names DPH-type metal-binding (MB) domain; CSL-type MB domain
Function The DHP-type or CSL-type MB domain contains a Cys-X-Cys...Cys-X2-Cys motif which tetrahedrically coordinates either Fe or Zn, but Zn is much more tightly bound.

Propagated annotation [?]


Comments [?]

case <FTGroup:1>
Domain The DPH-type metal-binding (MB) domain can bind either zinc or iron ions.

Keywords [?]

Metal-binding
Iron
Zinc
end case


Features [?]

From: PS51074
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       DPH-type MB #        
BINDING     23     23       /ligand="Zn(2+)" /ligand_id="29105     C   1
BINDING     25     25       /ligand="Zn(2+)" /ligand_id="29105     C   1
BINDING     45     45       /ligand="Zn(2+)" /ligand_id="29105     C   1
BINDING     48     48       /ligand="Zn(2+)" /ligand_id="29105     C   1

Additional information [?]

Size range 50-75 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q6VUC1 (DPH3_CRIGR)
Scope
Eukaryota

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]