ProRule PRU00456
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00456 |
| Accession | PRU00456 |
| Dates | 29-JUN-2005 (Created)
19-NOV-2022 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51074; DPH_MB |
Name | DPH-type metal-binding (MB) domain |
| Function | The DHP-type or CSL-type MB domain contains a Cys-X-Cys...Cys-X2-Cys motif which tetrahedrically coordinates either Fe or Zn, but Zn is much more tightly bound. |
| Scope(s) |
Eukaryota |
| Example(s) | Q6VUC1 (DPH3_CRIGR); |
Propagated annotation
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Comments
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| case <FTGroup:1> | |
| DOMAIN | The DPH-type metal-binding (MB) domain can bind either zinc or iron ions. |
Keywords
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| Metal-binding | |
| Iron | |
| Zinc | |
| end case | |
Features
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| From: PS51074 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="DPH-type MB #" | |||||||||
| BINDING | 23 | 23 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 25 | 25 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 45 | 45 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 48 | 48 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 50-75 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [40] All [ 40 ]
- Retrieve set of proteins with 3D structure for this domain