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ProRule PRU00456


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PURL: https://purl.expasy.org/prosite/rule/PRU00456
General rule information [?]

Accession PRU00456
Dates 29-JUN-2005 (Created)
19-NOV-2022 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS51074; DPH_MB
Name DPH-type metal-binding (MB) domain
Function The DHP-type or CSL-type MB domain contains a Cys-X-Cys...Cys-X2-Cys motif which tetrahedrically coordinates either Fe or Zn, but Zn is much more tightly bound.
Scope(s) Eukaryota
Example(s) Q6VUC1;

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
DOMAINThe DPH-type metal-binding (MB) domain can bind either zinc or iron ions.

Keywords [?]

Metal-binding
Iron
Zinc
end case

Features [?]

From: PS51074
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="DPH-type MB #"
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 25 25 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 45 45 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 48 48 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1

Additional information [?]

Size range 50-75 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]