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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00456


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00456
General rule information [?]

Accession PRU00456
Dates 29-JUN-2005 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS51074; DPH_MB
Name DPH-type metal-binding (MB) domain
Function The DHP-type or CSL-type MB domain contains a Cys-X-Cys...Cys-X2-Cys motif which tetrahedrically coordinates either Fe or Zn, but Zn is much more tightly bound.
Scope(s) Eukaryota
Example(s) Q6VUC1;

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
DOMAINThe DPH-type metal-binding (MB) domain can bind either zinc or iron ions.

Keywords [?]

Metal-binding
Iron
Zinc
end case

Features [?]

From: PS51074
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="DPH-type MB #"
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 25 25 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 45 45 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 48 48 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1

Additional information [?]

Size range 50-75 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]