ProRule PRU00457
General rule information
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| Accession | PRU00457 |
| Dates | 29-JUN-2005 (Created)
27-MAR-2023 (Last updated, Version 12) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50994; INTEGRASE |
Name | Integrase catalytic domain |
| Function | The integrase catalytic domain catalyzes a series of reactions to integrate the viral genome into a host chromosome. |
| Scope(s) |
Eukaryota Bacteria Viruses |
| Example(s) | O92956 (POL_RSVSB); |
Propagated annotation
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Keywords
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| case <FTGroup:1> | |
| Hydrolase | |
| Nuclease | |
| Endonuclease | |
| DNA integration | |
| DNA recombination | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0004518; Molecular function:nuclease activity | |
| GO:0004519; Molecular function:endonuclease activity | |
| GO:0016787; Molecular function:hydrolase activity | |
| GO:0006310; Molecular function:DNA recombination | |
| GO:0006313; Molecular function:DNA transposition | |
| end case | |
Features
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| From: PS50994 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Integrase catalytic #" | |||||||||
| BINDING | 12 | 12 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_note="catalytic" |
D | 1 | |||||||
| BINDING | 71 | 71 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_note="catalytic" |
D | 1 | |||||||
Additional information
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| Size range | 43-217 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [72] Eukaryota [93] Viruses [125] All [ 290 ]
- Retrieve set of proteins with 3D structure for this domain