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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00457


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00457
General rule information [?]

Accession PRU00457
Dates 29-JUN-2005 (Created)
27-MAR-2023 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS50994; INTEGRASE
Name Integrase catalytic domain
Function The integrase catalytic domain catalyzes a series of reactions to integrate the viral genome into a host chromosome.
Scope(s) Eukaryota
Bacteria
Viruses
Example(s) O92956;

Propagated annotation [?]

Keywords [?]

case <FTGroup:1>
Hydrolase
Nuclease
Endonuclease
DNA integration
DNA recombination
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0004518; Molecular function:nuclease activity
GO:0004519; Molecular function:endonuclease activity
GO:0016787; Molecular function:hydrolase activity
GO:0006310; Molecular function:DNA recombination
GO:0006313; Molecular function:DNA transposition
end case

Features [?]

From: PS50994
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Integrase catalytic #"
BINDING 12 12 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_note="catalytic"		 D 1
BINDING 71 71 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_note="catalytic"		 D 1

Additional information [?]

Size range 43-217 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]