We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00469
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00469
General rule information
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| Accession | PRU00469 |
| Dates | 10-AUG-2005 (Created)
19-NOV-2022 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51134; ZF_TFIIB |
Name | Zinc finger TFIIB-type |
| Function | The zinc finger contacts the rbp1 subunit of Pol II through its dock domain |
| Scope(s) |
Eukaryota Archaea |
| Example(s) | Q00403; |
Propagated annotation
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Keywords
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| Zinc-finger | |
| case <Feature:PS51134:5=[CH]> and <Feature:PS51134:8=[HC]> and <Feature:PS51134:24=[CH]> and <Feature:PS51134:27=[CH]> | |
| Zinc | |
| Metal-binding | |
| end case | |
Features
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| From: PS51134 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <Feature:PS51134:5=[C]> and <Feature:PS51134:8=[CH]> and <Feature:PS51134:24=[C]> and <Feature:PS51134:27=[C]> | ||||||||||||
| ZN_FING | from | to | /note="TFIIB-type #" | |||||||||
| else case <Feature:PS51134:5=[CH]> and <Feature:PS51134:8=[HC]> and <Feature:PS51134:24=[CH]> and <Feature:PS51134:27=[CH]> | ||||||||||||
| ZN_FING | from | to | /note="TFIIB-type #; atypical" | |||||||||
| else | ||||||||||||
| ZN_FING | from | to | /note="TFIIB-type #; degenerate" | |||||||||
| end case | ||||||||||||
| BINDING | 5 | 5 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 8 | 8 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 24 | 24 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 27 | 27 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
Additional information
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| Size range | 18-33 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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