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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00477


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00477
General rule information [?]

Accession PRU00477
Dates 16-AUG-2005 (Created)
21-NOV-2019 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS50847; GRAM_POS_ANCHORING
Name LPXTG sorting signal motif
Function The LPXTG motif is part of the C-terminal sorting signal found in surface proteins from Gram-positive cocci.
Scope(s) Bacteria
Example(s) P13050;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONSecreted, cell wall; Peptidoglycan-anchor.

Keywords [?]

Cell wall
Peptidoglycan-anchor
Secreted

Gene Ontology [?]

GO:0005618; Cellular component:cell wall

Cross-references [?]

General Transmembrane; -; 1;

Features [?]

From: PS50847
Key From To Description Tag Condition FTGroup
PROPEP 5 Cter /note="Removed by sortase"
MOTIF from 5 /note="LPXTG sorting signal"
MOD_RES 4 4 /note="Pentaglycyl murein peptidoglycan amidated threonine" T
MOD_RES 4 4 /note="Pentaglycyl murein peptidoglycan amidated alanine" A

Additional information [?]

Size range 30-40 amino acids
Related rules None
Fusion None
Repeats 1
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]