We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS50847

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PURL: https://purl.expasy.org/prosite/signature/PS50847

Direct ScanProsite submission

General information about the entry

Entry name [info]	GRAM_POS_ANCHORING
Accession [info]	PS50847
Entry type [info]	MATRIX
Date [info]	01-MAY-2002 CREATED; 26-FEB-2020 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00373
Associated ProRule [info]	PRU00477

Name and characterization of the entry

Description [info]

Gram-positive cocci surface proteins LPxTG motif profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=39;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=36;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.9159126; R2=0.0060830; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3385.1904297; R2=0.9610918; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=918; H_SCORE=4267; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=590; H_SCORE=3952; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-49; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='L';  M= -97, -99,-115,-107, -70,-116, -98, -62,-108,  97, -58,-114,-114,-101,-105,-107, -93, -69,-101, -83;
/M: SY='P';  M=   5,-117, -97, -86,-115, -95, -99,-103, -93,-112, -99,-101, 127, -95,-104, -24, -87,-105,-109,-112;
/M: SY='D';  M= -12,-105,  48,  42,-104, -96,  -3,-101,  39, -31, -94,  25, -95,  41,  -7,   5,   3, -33,-110, -16;
/M: SY='T';  M= -21, -91, -88, -90, -98, -97, -98, -89, -87, -93, -90, -77, -89, -92, -96, -66, 120, -81,-118, -96;
/M: SY='G';  M= -27,-105, -93,-104,-112, 104, -99,-119, -98,-115,-104,  -9, -98, -96,-105, -32, -96,-112,-104,-107;
/I:         I=-26; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='E';  M=   2,-102,  60,  61,  -6, -93, -87,-101, -40, -75, -98,  36, -94, -79, -41,  32,  22, -28,-113, -96;
/M: SY='N';  M= -19,-101,   5,  42,-106,   3,  14, -32,  30,-103, -96,  53, -94, -38, -25,  33,  32, -52,-113, -97;
/M: SY='D';  M=   5,-103,  49,   4,-101,  14, -89,  11, -13, -46,  -5,  30, -30,  13, -19,  29,   4, -64,-110, -17;
/M: SY='N';  M= -29, -99, -17,   9, -61, -38, -20, -25, -19, -50,   8,  62,   7, -39, -90,  43,  51, -31,-108,  14;
/M: SY='N';  M=  -1,-102,   1, -19,  16, -78, -10,   0, -21,   7, -17,  54,  11,   5, -13,  21, -55,  11,  -8, -38;
/M: SY='F';  M=   3,-102, -27, -61,  34,  -1, -93,  13, -18,  28, -81,  26,   8,  -6, -19, -10,  -7, -25,  10,  15;
/M: SY='M';  M=  18,-100,-101, -98,  28,  16, -95,  -8, -43,  40,  53, -32,   8, -41, -99,   3,  20, -80,-100, -28;
/M: SY='T';  M=  35, -97, -96, -34,   2, -27,   9, -36, -39,  25,   2, -56,   6, -32, -96, -17,  64, -16,   9, -89;
/M: SY='L';  M=  33, -99,-107,-102, -16, -20,-102,  32,-101,  55, -24,-101,-105, -98,-103, -61,  19,  13,  38, -24;
/M: SY='G';  M=  37,-100,-104,-101,  29,  38,-101,   4,-101,  30,  -3, -97,  19, -98,-104, -27, -88,  24,-101, -88;
/I:         I=-20; MD=-50;
/M: SY='G';  M=  24,-105,-104,-105,  30,  68,-104, -48, -25,   9, -91, -93,-105,-101,-105, -36, -22, -21,  14, -93; D=-20;
/I:         I=-20; MD=-50;
/M: SY='L';  M=  38,-105, -73,-106, -94,  37,-104, -28,-106,  42,  -1,-101,-109,-101,-108,   2, -93,  -4,-109, -28; D=-20;
/I:         I=-20; MD=-50;
/M: SY='T';  M=  21,-118,-125,-122, -43, -34,-124,  -7,-120,  -1,  -6,-117,-123,-119,-124, -40,  22,  20,-130,-113; D=-20;
/I:         I=-20; MI=0; MD=-50; IM=0; DM=-50;
/M: SY='M';  M=  -9, -99,-109,-104,  31, -16, -98,  18,-103,  60,  63,-102,-107, -98,-103,  -3, -24,   9,-100, -81;
/M: SY='L';  M=  27, -98,-107,-102,  13, -16, -99,   6,-101,  57,  36,-100,-105, -97,-102,   7, -21,  23,-102, -85;
/M: SY='G';  M=  39,  10, -99, -99, -25,  44,-100,  -5, -97,  22, -12, -90,-100, -95,-102,  16,  31,   4,-106, -94;
/M: SY='L';  M=  36, -98,-107,-102, -33,  -9,-102,  39,-102,  54,   5,-100,-105, -97,-103,   0, -46,  19,-104, -89;
/M: SY='G';  M=  26,-100,-100,-100,  -7,  59,-100, -13, -43,  19,   4, -90,-101, -95,-101,  22, -17,  12,-105, -94;
/M: SY='G';  M=  12,  12, -95, -49, -30,  78, -98, -29, -97,  -7, -94, -85, -99, -94,-103,  31,   5, -95,-104, -24;
/M: SY='L';  M=  42, -98,-104, -99, -83, -63,   9,  12,-100,  59, -17, -98,-104, -95,-101,   7,  12,   0,-106, -44;
/M: SY='F';  M=   9, -17,-108,-104,  48,   7, -98,  -1, -44,  34,  22,-101,-108,-100, -39, -47, -48,  40, -95,  23;
/M: SY='L';  M=  11,-102,-109,-105,  14,  -1,-100,  36,-101,  61, -71,-104,-109, -52, -15, -47, -58, -15, -98,   8;
/M: SY='Y';  M=  -3,-104,-108,-102,  35, -30, -95,  21, -15,  41, -12,-102, -37, -97,   4, -48, -56,  10,  -6,  55;
/M: SY='K';  M=   7,-104, -97, -90,  -4,  15,  11, -39,  48, -20,  -5, -89,-102, -85,  43, -22,  -4,  18,-102,  15;
/M: SY='R';  M= -24,-108, -91, -49, -15, -60, -88,-105,  68, -49, -94, -28,-101, -15,  84, -11, -29, -55,-105, -93;
/M: SY='K';  M= -39,-109, -33, -80, -29, -37, -86,-109,  76,-107, -97,  30,  -3, -75,  75, -33, -90,-105,-105, -36;
/M: SY='R';  M= -55,-110, -87,   6,-108,-103,  -3,-111,  70,-106, -96, -27, -99,   7,  87, -88,  -8,-105,-107, -95;
/M: SY='K';  M= -14,-112,  -5,  32, -40,-104, -92, -47,  79,-109,-100, -25, -24, -77,  46, -91, -43,-105,-110,-100;
/M: SY='N';  M= -56,-112, -12,  29,-115,  -7,  -4, -44,  -7, -60,-103,  67,-106,  34,   9,  17, -92, -63,-121,-105;
/M: SY='N';  M= -24,-118,  29, -24,-121, -16,  14,-116,  15, -73,-112,  31,-113, -11, -58,  25, -25, -24,-130,-112;
/M: SY='K';  M=-120,-137,   5, -21,-139, -26, -16,-135,  38,-137,-129,   0,-128,-108, -17,  -7,-116, -38,-143,-128;
/M: SY='K';  M=  -6,-144, -11,-123,-146,-135,-131, -32,  19,-140,-134,  15,-141,-122, -13,-125,-127, -52,-153,-139;
/M: SY='K';  M=-147,-160, -46,   8, -18,-155,-140,-158,   9,-155,-150, -30,-149,-129, -24,-140, -39,-155,-157,-143;
/M: SY='H';  M=-162,-174, -60, -70,-164,-170,   4,-160, -27, -30,-149, -64,-168,  -1,-147,-155, -56,-162,-178,-156;
/I:         E1=0; IE=-255; DE=-255;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	205 in 205 different sequences
Number of true positive hits	205 in 205 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	2

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	MOTIF
Feature description [info]	LPXTG sorting signal
Version [info]	8

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

205 sequences

ARP4_STRPY  (P13050), ASA1_ENTFA  (P17953), BAG_STRAG   (P27951),

BBP_STAAR   (Q6GJA6), BBP_STAAU   (Q14U76), BCA_STRA1   (Q02192), 
C5AP_STRP1  (P58099), C5AP_STRP3  (P0DD34), C5AP_STRP6  (Q5X9R0), 
C5AP_STRP8  (Q8NZ80), C5AP_STRPQ  (P0DD35), C5AP_STRPY  (P15926), 
CHPA_STRCO  (Q8CJY7), CHPB_STRCO  (Q9X7U2), CHPC_STRCO  (Q9AD93), 
CLFA_STAA8  (Q2G015), CLFA_STAAC  (Q5HHM8), CLFA_STAAE  (Q53653), 
CLFA_STAAM  (Q932C5), CLFA_STAAN  (Q99VJ4), CLFA_STAAR  (Q6GIK4), 
CLFA_STAAS  (Q6GB45), CLFA_STAAW  (Q8NXJ1), CLFB_STAA8  (Q2FUY2), 
CLFB_STAAC  (Q5HCR7), CLFB_STAAE  (O86476), CLFB_STAAM  (Q99R07), 
CLFB_STAAN  (Q7A382), CLFB_STAAR  (Q6GDH2), CLFB_STAAS  (Q6G644), 
CLFB_STAAW  (Q8NUL0), CNA_STAAU   (Q53654), DEXT_STRDO  (P39653), 
DEXT_STRMU  (Q54443), FAP1_STRPA  (A1C3L3), FBE_STAEP   (O70022), 
FM1_ACTVI   (P18477), FM2_ACTNA   (P12616), FNBA_STAA1  (A7X6I5), 
FNBA_STAA3  (Q2FE03), FNBA_STAA8  (P14738), FNBA_STAAB  (Q2YW62), 
FNBA_STAAC  (Q5HD51), FNBA_STAAM  (Q99RD2), FNBA_STAAN  (Q7A3J7), 
FNBA_STAAR  (Q6GDU5), FNBA_STAAS  (Q6G6H3), FNBA_STAAW  (Q8NUU7), 
FNBB_STAA3  (A0A0H2XKG3), FRUA_STRMU  (Q03174), GH101_RENSM (A9WNA0), 
GH101_STRPN (Q2MGH6), GH101_STRR6 (Q8DR60), GSPB_STRGN  (Q939N5), 
HSA_STRGC   (A8AWU7), HYLA_ENTFA  (Q82ZM8), HYSA_STRPN  (Q54873), 
IGA1A_STRPN (Q97QP7), IGA1B_STREE (Q54875), IGA1_STRR6  (Q59947), 
IGA1_STRSA  (Q59986), INLA_LISM4  (G2K3G6), INLA_LISMF  (Q723K6), 
INLA_LISMO  (P0DJM0), INLI_LISMF  (Q723X5), INLI_LISMO  (Q8YA32), 
INLJ_LISMF  (Q71VU0), INLJ_LISMO  (Q8Y3L4), INUS_LACJO  (Q74K42), 
ISDA_STAA1  (A7X148), ISDA_STAA2  (A6U0U7), ISDA_STAA3  (Q2FHV1), 
ISDA_STAA8  (Q2FZE9), ISDA_STAA9  (A5IS16), ISDA_STAAB  (Q2YX95), 
ISDA_STAAC  (Q5HGV4), ISDA_STAAE  (A6QG31), ISDA_STAAM  (Q99UX4), 
ISDA_STAAN  (Q7A655), ISDA_STAAR  (Q6GHV6), ISDA_STAAS  (Q6GA85), 
ISDA_STAAT  (A8Z1R0), ISDA_STAAU  (P0C1S5), ISDA_STAAW  (Q7A152), 
ISDB_STAA1  (A7X146), ISDB_STAA2  (A6U0U6), ISDB_STAA3  (Q2FHV2), 
ISDB_STAA8  (Q2FZF0), ISDB_STAA9  (A5IS15), ISDB_STAAB  (Q2YX96), 
ISDB_STAAC  (Q5HGV5), ISDB_STAAE  (A6QG30), ISDB_STAAM  (Q99UX5), 
ISDB_STAAN  (Q7A656), ISDB_STAAR  (Q6GHV7), ISDB_STAAS  (Q6GA86), 
ISDB_STAAT  (P0C7J5), ISDB_STAAW  (Q8NX66), ISDH_STAA3  (Q2FG07), 
ISDH_STAA8  (Q2FXJ2), ISDH_STAAB  (Q2YTF7), ISDH_STAAC  (Q5HF43), 
ISDH_STAAM  (Q931P4), ISDH_STAAN  (Q99TD3), ISDH_STAAS  (Q6G8J7), 
ISDH_STAAW  (Q8NW39), LSC_FRUSA   (Q70XJ9), LSC_LACGS   (D3WYW0), 
M12_STRPY   (P19401), M21_STRPY   (P50468), M22_STRPY   (P50469), 
M24_STRPY   (P12379), M49_STRP9   (P16947), M5_STRP5(P02977), 
M6A_STRP6   (Q5X9Q9), M6B_STRPY   (P08089), MANA_BIFAA  (A1A278), 
MRP4_STRPY  (P30141), MRP_STRSU   (P32653), MX_STRP9(P16946), 
NANA_STREE  (P62575), NANA_STRR6  (P62576), NISP_LACLL  (Q07596), 
NTPES_BACSU (O34313), P1P_LACLC   (P16271), P2P_LACLC   (P15293), 
P2P_LACPA   (Q02470), P3P_LACLS   (P15292), PAA_STRCG   (Q9LBG3), 
PAB_FINMA   (Q51911), PAC_STRMG   (P11657), PADA_STRGC  (A8AZP4), 
PAS_STRIT   (Q9KW51), PFBA_STRR6  (Q8CYC9), PLS_STAAC   (Q5HJU7), 
PLS_STAAM   (Q931E9), PLS_STAAN   (P61598), PLS_STAAU   (P80544), 
PLS_STAAW   (Q8NUV0), PLS_STAES   (Q8CQD9), PSRP_STRPN  (A0A0H2URK1), 
PULA_STREE  (Q9F930), PULA_STRP2  (A0A0H2ZL64), PULA_STRPN  (A0A0H2UNG0), 
SASG_STAA8  (Q2G2B2), SDRC_STAA3  (Q2FJ79), SDRC_STAA8  (Q2G0L5), 
SDRC_STAAC  (Q5HIB4), SDRC_STAAE  (O86487), SDRC_STAAM  (Q99W48), 
SDRC_STAAN  (Q7A781), SDRC_STAAR  (Q6GJA7), SDRC_STAAS  (Q6GBS6), 
SDRC_STAAW  (Q8NXX7), SDRD_STAA3  (Q2FJ78), SDRD_STAA8  (Q2G0L4), 
SDRD_STAAC  (Q5HIB3), SDRD_STAAE  (O86488), SDRD_STAAM  (Q99W47), 
SDRD_STAAN  (Q7A780), SDRD_STAAS  (Q6GBS5), SDRD_STAAW  (Q8NXX6), 
SDRE_STAA3  (Q2FJ77), SDRE_STAAC  (Q5HIB2), SDRE_STAAE  (O86489), 
SDRE_STAAM  (Q932F7), SDRE_STAAN  (Q99W46), SDRE_STAAS  (Q6GBS4), 
SDRE_STAAW  (Q8NXX5), SDRF_STAEP  (Q9KI14), SDRF_STAES  (Q8CMP4), 
SDRG_STAEP  (Q9KI13), SDRI_STASA  (Q8KWM1), SPAA_STRDO  (P21979), 
SPAP_STRMU  (P23504), SPA_STAA8   (P02976), SPA_STAAE   (A0A0H3K686), 
SPA_STAAM   (P0A015), SPA_STAAN   (P99134), SPA_STAAU   (P38507), 
SPG1_STRSG  (P06654), SPG2_STRSG  (P19909), SPH_STRP1   (P50470), 
SRAP_STAA3  (Q2FDK5), SRAP_STAA8  (Q2FUW1), SRAP_STAAC  (Q5HCP3), 
SRAP_STAAM  (Q99QY4), SRAP_STAAN  (Q7A362), SRAP_STAAR  (Q6GDE9), 
SRAP_STAAS  (Q6G620), SRAP_STAAU  (Q8VQ99), SRAP_STAAW  (Q8NUJ3), 
SRAP_STAHJ  (Q4L9P0), SSPA_STRGC  (A8AUS0), SSPB_STRGC  (A8AUS1), 
SSPB_STRGN  (P16952), STRH_STRPN  (P49610), TEE6_STRP6  (P18481), 
UAFA_STAS1  (Q4A0V8), WAPA_STRMU  (P11000), Y2714_LISMO (Q8Y3W5), 
YHCR_BACSU  (P54602), ZMPB_STRPN  (Q9L7Q2), ZMPB_STRR6  (Q8DQN5), 
ZMPC_STRPN  (Q97T80)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
'Partial' sequences

2 sequences

M32_STRTR   (P83330), PAM_STRPY   (P49054)