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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00480


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00480
General rule information [?]

Accession PRU00480
Dates 26-AUG-2005 (Created)
19-NOV-2022 (Last updated, Version 12)
Data class Domain;
Predictors PROSITE; PS51130; PDXT_SNO_2
Name PdxT/SNO family
Function PdxS/SNZ and pdxT/SNO proteins form a complex which serves as a glutamine amidotransferase to supply ammonia as a source of the ring nitrogen of vitamin B6. PdxT/SNO appear to encode the glutaminase subunit, which produces ammonia from glutamine.
Scope(s) Eukaryota
Bacteria
Archaea
Example(s) Q03144;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FT:1>
Protein name AltName: Full=Probable glutamine amidotransferase;
                 EC=2.6.-.-;
end case

Comments [?]

SIMILARITYBelongs to the glutamine amidotransferase pdxT/SNO family.

Keywords [?]

case <FT:1>
Glutamine amidotransferase
Transferase
end case
case <OC:Bacteria> or <OG:Archaea>
Pyridoxal phosphate
end case
case <OC:Eukaryota>
Pyridoxine biosynthesis
end case

Gene Ontology [?]

case <FT:1>
GO:0006541; Biological process:glutamine metabolic process
GO:0016740; Molecular function:transferase activity
end case
case <OCellular component:Eukaryota> and <FT:1>
GO:0008615; Biological process:pyridoxine biosynthetic process
end case

Cross-references [?]

PROSITE PS01236; PDXT_SNO_1; 1;

Features [?]

From: PS51130
Key From To Description Tag Condition FTGroup
ACT_SITE 79 79 /note="Nucleophile" C
case <Feature:PS51130:79=C>
ACT_SITE 176 176 H
ACT_SITE 178 178 E
end case
BINDING 111 111 /ligand="L-glutamine"
/ligand_id="ChEBI:CHEBI:58359"		 R

Additional information [?]

Size range 170-215 amino acids
Related rules PRU00605
PRU00606
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]