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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00517


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00517
General rule information [?]

Accession PRU00517
Dates 09-DEC-2005 (Created)
03-SEP-2024 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS51171; PREPHENATE_DEHYDR_3
Name prephenate dehydratase domain
Function Prephenate dehydratase (EC 4.2.1.51) catalyzes the decarboxylation of prephenate into phenylpyruvate.
Scope(s) Bacteria
Archaea
Eukaryota
Fungi
Viridiplantae
Example(s) P32452;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=4.2.1.51;

Comments [?]

CATALYTIC ACTIVITY Reaction=prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O; Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934; EC=4.2.1.51;

Keywords [?]

Phenylalanine biosynthesis
Aromatic amino acid biosynthesis
Amino-acid biosynthesis
Lyase

Gene Ontology [?]

GO:0009094; Biological process:L-phenylalanine biosynthetic process
GO:0009073; Biological process:aromatic amino acid family biosynthetic process
GO:0008652; Biological process:amino acid biosynthetic process
GO:0016829; Molecular function:lyase activity

Features [?]

From: PS51171
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Prephenate dehydratase #"

Additional information [?]

Size range 170-230 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]