ProRule PRU00525
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00525 |
| Accession | PRU00525 |
| Dates | 18-JAN-2006 (Created)
19-NOV-2022 (Last updated, Version 10) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50258; LNR |
Name | Lin-12/Notch (LNR) repeat |
| Function | The LNR is supposed to negatively regulates the Lin-12/Notch proteins activity, and participates in maintaining the receptor in its resting conformation prior to ligand binding. |
| Scope(s) |
Eukaryota |
| Example(s) | Q3T906 (GNPTA_HUMAN); |
Propagated annotation
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Keywords
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| case <FTGroup:1> | |
| Calcium | |
| Metal-binding | |
| end case | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| GO:0005509; Molecular function:calcium ion binding |
| GO:0007219; Biological process:Notch signaling pathway |
Cross-references
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| PROSITE | PS50258; LNR; 1-3; |
Features
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| From: PS50258 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REPEAT | entry | exit | /note="LNR #" | |||||||||
| DISULFID | 1 | 25 | disulf | C-x*-C | ||||||||
| DISULFID | 7 | 20 | disulf | C-x*-C | ||||||||
| DISULFID | 16 | 32 | disulf | C-x*-C | ||||||||
| BINDING | 13 | 13 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" |
[DN] | 1 | |||||||
| BINDING | 28 | 28 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" |
D | 1 | |||||||
| BINDING | 31 | 31 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" |
[DE] | 1 | |||||||
Additional information
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| Size range | 35-45 amino acids |
| Related rules |
none |
| Fusion | None |
| Repeats | 1-3 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [21] All [ 21 ]
- Retrieve set of proteins with 3D structure for this domain