General rule information
[?]
Accession |
PRU00525 |
Dates |
18-JAN-2006 (Created) 19-NOV-2022 (Last updated, Version 10) |
Name |
Lin-12/Notch (LNR) repeat |
Function |
The LNR is supposed to negatively regulates the Lin-12/Notch proteins activity, and participates in maintaining the receptor in its resting conformation prior to ligand binding. |
Propagated annotation
[?]
GO:0005509; Molecular function: calcium ion binding.
GO:0007219; Biological process: Notch signaling pathway.
case <FTGroup:1>
end case
case <FTTag:disulf>
end case
From: PS50258 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
REPEAT
|
|
entry
|
|
exit
|
|
LNR #
|
|
|
|
|
|
|
DISULFID
|
|
1
|
|
25
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
7
|
|
20
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
16
|
|
32
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
BINDING
|
|
13
|
|
13
|
|
/ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108
|
|
|
|
[DN]
|
|
1
|
BINDING
|
|
28
|
|
28
|
|
/ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108
|
|
|
|
D
|
|
1
|
BINDING
|
|
31
|
|
31
|
|
/ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108
|
|
|
|
[DE]
|
|
1
|
Additional information
[?]
Size range |
35-45 amino acids |
Related rules |
none |
Repeats |
1-3 |
Topology |
Undefined |
Example |
Q3T906 (GNPTA_HUMAN) |
Scope |
Eukaryota |
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distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]