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annotation rule: PRU00525

General rule information [?]

Accession PRU00525
Dates 18-JAN-2006 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain
Predictors PROSITE; PS50258; LNR
Name Lin-12/Notch (LNR) repeat
Function The LNR is supposed to negatively regulates the Lin-12/Notch proteins activity, and participates in maintaining the receptor in its resting conformation prior to ligand binding.

Propagated annotation [?]


Cross-references [?]

PROSITE PS50258; LNR; 1-3;

Gene Ontology [?]

GO:0005509; Molecular function: calcium ion binding.
GO:0007219; Biological process: Notch signaling pathway.

Keywords [?]

case <FTGroup:1>
Calcium
Metal-binding
end case

case <FTTag:disulf>
Disulfide bond
end case


Features [?]

From: PS50258
Key     From     To       Description   Tag   Condition   FTGroup
REPEAT     entry     exit       LNR #        
DISULFID     1     25           disulf   C-x*-C  
DISULFID     7     20           disulf   C-x*-C  
DISULFID     16     32           disulf   C-x*-C  
BINDING     13     13       /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108     [DN]   1
BINDING     28     28       /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108     D   1
BINDING     31     31       /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108     [DE]   1

Additional information [?]

Size range 35-45 amino acids
Related rules none
Repeats 1-3
Topology Undefined
Example Q3T906 (GNPTA_HUMAN)
Scope
Eukaryota

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]