ProRule PRU00525

General rule information [?]

Accession PRU00525
Dates 18-JAN-2006 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS50258; LNR
Name Lin-12/Notch (LNR) repeat
Function The LNR is supposed to negatively regulates the Lin-12/Notch proteins activity, and participates in maintaining the receptor in its resting conformation prior to ligand binding.
Scope(s) Eukaryota
Example(s) Q3T906 (GNPTA_HUMAN);

Propagated annotation [?]

Keywords [?]

case <FTGroup:1>
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

GO:0005509; Molecular function:calcium ion binding
GO:0007219; Biological process:Notch signaling pathway

Cross-references [?]

PROSITE PS50258; LNR; 1-3;

Features [?]

From: PS50258
Key From To Description Tag Condition FTGroup
REPEAT entry exit /note="LNR #"
DISULFID 1 25 disulf C-x*-C
DISULFID 7 20 disulf C-x*-C
DISULFID 16 32 disulf C-x*-C
BINDING 13 13 /ligand="Ca(2+)"
[DN] 1
BINDING 28 28 /ligand="Ca(2+)"
D 1
BINDING 31 31 /ligand="Ca(2+)"
[DE] 1

Additional information [?]

Size range 35-45 amino acids
Related rules none
Fusion None
Repeats 1-3
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB rule member sequences [?]