ProRule PRU00585
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00585 |
| Accession | PRU00585 |
| Dates | 16-JAN-2007 (Created)
21-NOV-2019 (Last updated, Version 5) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51256; GS |
Name | GS domain |
| Function | The GS domain is a short (~30 residues), highly conserved regulatory sequence which is found N-terminal to the kinase domain on the cytoplasmic side of members of the type I TGF-beta receptor (TbetaR-I) family. At least three, and perhaps four to five of the serines and threonines in the GS domain, must be phosphorylated to fully activate TbetaR-1. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | P36896 (ACV1B_HUMAN); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the Ser/Thr protein kinase family. TGFB receptor subfamily. |
Keywords
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Features
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| From: PS51256 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="GS #" | |||||||||
Additional information
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| Size range | 25-35 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [28] All [ 28 ]
- Retrieve set of proteins with 3D structure for this domain