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annotation rule: PRU00585

General rule information [?]

Accession PRU00585
Dates 16-JAN-2007 (Created)
21-NOV-2019 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS51256; GS
Name GS domain
Function The GS domain is a short (~30 residues), highly conserved regulatory sequence which is found N-terminal to the kinase domain on the cytoplasmic side of members of the type I TGF-beta receptor (TbetaR-I) family. At least three, and perhaps four to five of the serines and threonines in the GS domain, must be phosphorylated to fully activate TbetaR-1.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the Ser/Thr protein kinase family. TGFB receptor subfamily.

Keywords [?]

Phosphoprotein

Features [?]

From: PS51256
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       GS #        

Additional information [?]

Size range 25-35 amino acids
Related rules None
Repeats 1
Topology Cytoplasmic
Example P36896 (ACV1B_HUMAN)
Scope
Eukaryota; Metazoa

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]