ProRule PRU00585

General rule information [?]

Accession PRU00585
Dates 16-JAN-2007 (Created)
21-NOV-2019 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51256; GS
Name GS domain
Function The GS domain is a short (~30 residues), highly conserved regulatory sequence which is found N-terminal to the kinase domain on the cytoplasmic side of members of the type I TGF-beta receptor (TbetaR-I) family. At least three, and perhaps four to five of the serines and threonines in the GS domain, must be phosphorylated to fully activate TbetaR-1.
Scope(s) Eukaryota
Example(s) P36896 (ACV1B_HUMAN);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the Ser/Thr protein kinase family. TGFB receptor subfamily.

Keywords [?]

Features [?]

From: PS51256
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="GS #"

Additional information [?]

Size range 25-35 amino acids
Related rules None
Fusion None
Repeats 1
Topology Cytoplasmic


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UniProtKB rule member sequences [?]