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annotation rule: PRU00585 |
Accession | PRU00585 |
Dates | 16-JAN-2007 (Created) 21-NOV-2019 (Last updated, Version 5) |
Data class | Domain |
Predictors | PROSITE; PS51256; GS |
Name | GS domain |
Function | The GS domain is a short (~30 residues), highly conserved regulatory sequence which is found N-terminal to the kinase domain on the cytoplasmic side of members of the type I TGF-beta receptor (TbetaR-I) family. At least three, and perhaps four to five of the serines and threonines in the GS domain, must be phosphorylated to fully activate TbetaR-1. |
Similarity | Belongs to the Ser/Thr protein kinase family. TGFB receptor subfamily. |
From: PS51256 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | GS # |
Size range | 25-35 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Cytoplasmic |
Example | P36896 (ACV1B_HUMAN) |
Scope | Eukaryota; Metazoa |
Eukaryota | [28] |