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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00585


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00585
General rule information [?]

Accession PRU00585
Dates 16-JAN-2007 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51256; GS
Name GS domain
Function The GS domain is a short (~30 residues), highly conserved regulatory sequence which is found N-terminal to the kinase domain on the cytoplasmic side of members of the type I TGF-beta receptor (TbetaR-I) family. At least three, and perhaps four to five of the serines and threonines in the GS domain, must be phosphorylated to fully activate TbetaR-1.
Scope(s) Eukaryota
Metazoa
Example(s) P36896;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the Ser/Thr protein kinase family. TGFB receptor subfamily.

Keywords [?]

Phosphoprotein

Features [?]

From: PS51256
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="GS #"

Additional information [?]

Size range 25-35 amino acids
Related rules None
Fusion None
Repeats 1
Topology Cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]