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annotation rule: PRU00585

General rule information [?]

Accession PRU00585
Dates 16-JAN-2007 (Created)
16-DEC-2016 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS51256; GS
Name GS domain
Function The GS domain is a short (~30 residues), highly conserved regulatory sequence which is found N-terminal to the kinase domain on the cytoplasmic side of members of the type I TGF-beta receptor (TbetaR-I) family. At least three, and perhaps four to five of the serines and threonines in the GS domain, must be phosphorylated to fully activate TbetaR-1.

Propagated annotation [?]


Comments [?]

Similarity Belongs to the Ser/Thr protein kinase family. TGFB receptor subfamily.

Keywords [?]


Features [?]

From: PS51256
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       GS #        

Additional information [?]

Size range 25-35 amino acids
Related rules None
Repeats 1
Topology Cytoplasmic
Example P36896 (ACV1B_HUMAN)
Scope
Eukaryota; Metazoa

Copyright

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.



UniProtKB rule member sequences [?]