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| annotation rule: PRU00607 |
General rule information
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| Accession | PRU00607 |
| Dates | 8-DEC-2006 (Created) 28-OCT-2021 (Last updated, Version 12) |
| Data class | Domain |
| Predictors | PROSITE; PS51275; PEPTIDASE_C26_GGH |
| Names | Gamma-glutamyl hydrolase domain; Peptidase C26 family. GGH subfamily. |
| Function | Gamma-glutamyl hydrolase (GGH) (EC 3.4.19.9) is an enzyme that cleaves gamma-linked glutamyl bonds, and with particular substrate the enzyme acts as an endopeptidase. |
Propagated annotation
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Description
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case <FTGroup:1>
| + RecName: EC 3.4.19.9; |
Comments
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| Catalytic activity | RHEA:56784: (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate
EC 3.4.19.9 |
Gene Ontology
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GO:0034722; Molecular function: gamma-glutamyl-peptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0016787; Molecular function: hydrolase activity.
Keywords
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end case
Features
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| From: PS51275 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | Gamma-glutamyl hydrolase # | |||||||||
| ACT_SITE | 110 | 110 | Nucleophile | C | 1 | |||||||
| ACT_SITE | 222 | 222 | H | 1 | ||||||||
Additional information
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| Size range | 280-310 amino acids |
| Related rules | PRU00605 |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q92820 (GGH_HUMAN) |
| Scope | Eukaryota |
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UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Eukaryota [10]
- Retrieve set of proteins with 3D structure for this domain