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annotation rule: PRU00607

General rule information [?]

Accession PRU00607
Dates 8-DEC-2006 (Created)
28-OCT-2021 (Last updated, Version 12)
Data class Domain
Predictors PROSITE; PS51275; PEPTIDASE_C26_GGH
Names Gamma-glutamyl hydrolase domain; Peptidase C26 family. GGH subfamily.
Function Gamma-glutamyl hydrolase (GGH) (EC is an enzyme that cleaves gamma-linked glutamyl bonds, and with particular substrate the enzyme acts as an endopeptidase.

Propagated annotation [?]

Description [?]

case <FTGroup:1>
+ RecName: EC;

Comments [?]

Catalytic activity RHEA:56784: (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate

Gene Ontology [?]

GO:0034722; Molecular function: gamma-glutamyl-peptidase activity.
GO:0016787; Molecular function: hydrolase activity.

Keywords [?]

end case

Features [?]

From: PS51275
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Gamma-glutamyl hydrolase #        
ACT_SITE     110     110       Nucleophile     C   1
ACT_SITE     222     222             H   1

Additional information [?]

Size range 280-310 amino acids
Related rules PRU00605
Repeats 1
Topology Undefined
Example Q92820 (GGH_HUMAN)


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UniProtKB rule member sequences [?]