General rule information
[?]
Accession |
PRU00607 |
Dates |
8-DEC-2006 (Created) 28-OCT-2021 (Last updated, Version 12) |
Predictors |
PROSITE; PS51275; PEPTIDASE_C26_GGH
|
Names |
Gamma-glutamyl hydrolase domain; Peptidase C26 family. GGH subfamily. |
Function |
Gamma-glutamyl hydrolase (GGH) (EC 3.4.19.9) is an enzyme that cleaves gamma-linked glutamyl bonds, and with particular substrate the enzyme acts as an endopeptidase. |
Propagated annotation
[?]
case <FTGroup:1>
Catalytic activity |
RHEA:56784: (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate
EC 3.4.19.9
|
GO:0034722; Molecular function: gamma-glutamyl-peptidase activity.
GO:0016787; Molecular function: hydrolase activity.
end case
From: PS51275 |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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DOMAIN
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from
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to
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Gamma-glutamyl hydrolase #
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ACT_SITE
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110
|
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110
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Nucleophile
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|
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C
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1
|
ACT_SITE
|
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222
|
|
222
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|
|
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H
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1
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Additional information
[?]
Size range |
280-310 amino acids |
Related rules |
PRU00605 |
Repeats |
1 |
Topology |
Undefined |
Example |
Q92820 (GGH_HUMAN) |
Scope |
Eukaryota |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]