ProRule PRU00607
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00607 |
| Accession | PRU00607 |
| Dates | 8-DEC-2006 (Created)
28-OCT-2021 (Last updated, Version 12) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51275; PEPTIDASE_C26_GGH |
Name | Gamma-glutamyl hydrolase domain |
| Function | Gamma-glutamyl hydrolase (GGH) (EC 3.4.19.9) is an enzyme that cleaves gamma-linked glutamyl bonds, and with particular substrate the enzyme acts as an endopeptidase. |
| Scope(s) |
Eukaryota |
| Example(s) | Q92820 (GGH_HUMAN); |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> | |
| Protein name | + RecName: EC=3.4.19.9; |
Comments
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| CATALYTIC ACTIVITY | Reaction=(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate; Xref=Rhea:RHEA:56784, Rhea:RHEA-COMP:14738, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:57453, ChEBI:CHEBI:141005; EC=3.4.19.9; |
Keywords
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| Hydrolase | |
| end case | |
Gene Ontology
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| GO:0034722; Molecular function:gamma-glutamyl-peptidase activity |
| GO:0016787; Molecular function:hydrolase activity |
Features
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| From: PS51275 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Gamma-glutamyl hydrolase #" | |||||||||
| ACT_SITE | 110 | 110 | /note="Nucleophile" | C | 1 | |||||||
| ACT_SITE | 222 | 222 | H | 1 | ||||||||
Additional information
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| Size range | 280-310 amino acids |
| Related rules |
PRU00605 |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [10] All [ 10 ]
- Retrieve set of proteins with 3D structure for this domain