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annotation rule: PRU00607

General rule information [?]

Accession PRU00607
Dates 8-DEC-2006 (Created)
21-NOV-2019 (Last updated, Version 11)
Data class Domain
Predictors PROSITE; PS51275; PEPTIDASE_C26_GGH
Names Gamma-glutamyl hydrolase domain; Peptidase C26 family. GGH subfamily.
Function Gamma-glutamyl hydrolase (GGH) (EC 3.4.19.9) is an enzyme that cleaves gamma-linked glutamyl bonds, and with particular substrate the enzyme acts as an endopeptidase.

Propagated annotation [?]


Description [?]

case <FTGroup:1>
+ RecName: EC 3.4.19.9;

Comments [?]

Catalytic activity RHEA:56784: (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate
EC 3.4.19.9

Gene Ontology [?]

GO:0034722; Molecular function: gamma-glutamyl-peptidase activity.
GO:0016787; Molecular function: hydrolase activity.

Keywords [?]

end case


Features [?]

From: PS51275
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Gamma-glutamyl hydrolase #        
ACT_SITE     110     110       Nucleophile     C   1
ACT_SITE     222     222             H   1

Additional information [?]

Size range 280-310 amino acids
Related rules PRU00605
Repeats 1
Topology Undefined
Example Q92820 (GGH_HUMAN)
Scope
Eukaryota

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]