ProRule PRU00607

General rule information [?]

Accession PRU00607
Dates 8-DEC-2006 (Created)
28-OCT-2021 (Last updated, Version 12)
Data class Domain;
Predictors PROSITE; PS51275; PEPTIDASE_C26_GGH
Name Gamma-glutamyl hydrolase domain
Function Gamma-glutamyl hydrolase (GGH) (EC is an enzyme that cleaves gamma-linked glutamyl bonds, and with particular substrate the enzyme acts as an endopeptidase.
Scope(s) Eukaryota
Example(s) Q92820 (GGH_HUMAN);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=;

Comments [?]

CATALYTIC ACTIVITY Reaction=(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate; Xref=Rhea:RHEA:56784, Rhea:RHEA-COMP:14738, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:57453, ChEBI:CHEBI:141005; EC=;

Keywords [?]

end case

Gene Ontology [?]

GO:0034722; Molecular function:gamma-glutamyl-peptidase activity
GO:0016787; Molecular function:hydrolase activity

Features [?]

From: PS51275
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Gamma-glutamyl hydrolase #"
ACT_SITE 110 110 /note="Nucleophile" C 1
ACT_SITE 222 222 H 1

Additional information [?]

Size range 280-310 amino acids
Related rules PRU00605
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]