ProRule PRU00634

General rule information [?]

Accession PRU00634
Dates 4-JAN-2012 (Created)
21-NOV-2019 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51234; TSP3
Name Thrombospondin type-3 (TSP3) repeat
Function The calcium-binding TSP3 repeats are a tandem of aspartic acid-rich motifs, which resembles EF hands in the acidic side chains. But unlike EF hands, the calcium-binding loops of the TSP3 repeats are not flanked by secondary structure elements. The individual calcium-binding repeats are linked by disulfide bonds to each other.
Scope(s) Eukaryota
Example(s) P35442 (TSP2_HUMAN);

Propagated annotation [?]

Keywords [?]

Gene Ontology [?]

GO:0005509; Molecular function:calcium ion binding

Features [?]

From: PS51234
Key From To Description Tag Condition FTGroup
REPEAT from to /note="TSP type-3 #"

Additional information [?]

Size range 13-53 amino acids
Related rules None
Fusion None
Repeats 8
Topology Undefined


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UniProtKB rule member sequences [?]