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| annotation rule: PRU00634 |
General rule information
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| Accession | PRU00634 |
| Dates | 4-JAN-2012 (Created) 21-NOV-2019 (Last updated, Version 3) |
| Data class | Domain |
| Predictors | PROSITE; PS51234; TSP3 |
| Name | Thrombospondin type-3 (TSP3) repeat |
| Function | The calcium-binding TSP3 repeats are a tandem of aspartic acid-rich motifs, which resembles EF hands in the acidic side chains. But unlike EF hands, the calcium-binding loops of the TSP3 repeats are not flanked by secondary structure elements. The individual calcium-binding repeats are linked by disulfide bonds to each other. |
Propagated annotation
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Gene Ontology
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GO:0005509; Molecular function: calcium ion binding.
Keywords
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Features
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| From: PS51234 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REPEAT | from | to | TSP type-3 # | |||||||||
Additional information
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| Size range | 13-53 amino acids |
| Related rules | None |
| Repeats | 8 |
| Topology | Undefined |
| Example | P35442 (TSP2_HUMAN) |
| Scope | Eukaryota |
| Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [23]
- Retrieve set of proteins with 3D structure for this domain