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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00634


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00634
General rule information [?]

Accession PRU00634
Dates 04-JAN-2012 (Created)
21-NOV-2019 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51234; TSP3
Name Thrombospondin type-3 (TSP3) repeat
Function The calcium-binding TSP3 repeats are a tandem of aspartic acid-rich motifs, which resembles EF hands in the acidic side chains. But unlike EF hands, the calcium-binding loops of the TSP3 repeats are not flanked by secondary structure elements. The individual calcium-binding repeats are linked by disulfide bonds to each other.
Scope(s) Eukaryota
Example(s) P35442;

Propagated annotation [?]

Keywords [?]

Calcium

Gene Ontology [?]

GO:0005509; Molecular function:calcium ion binding

Features [?]

From: PS51234
Key From To Description Tag Condition FTGroup
REPEAT from to /note="TSP type-3 #"

Additional information [?]

Size range 13-53 amino acids
Related rules None
Fusion None
Repeats 8
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]