ProRule PRU00634
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00634 |
| Accession | PRU00634 |
| Dates | 4-JAN-2012 (Created)
21-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51234; TSP3 |
Name | Thrombospondin type-3 (TSP3) repeat |
| Function | The calcium-binding TSP3 repeats are a tandem of aspartic acid-rich motifs, which resembles EF hands in the acidic side chains. But unlike EF hands, the calcium-binding loops of the TSP3 repeats are not flanked by secondary structure elements. The individual calcium-binding repeats are linked by disulfide bonds to each other. |
| Scope(s) |
Eukaryota |
| Example(s) | P35442 (TSP2_HUMAN); |
Propagated annotation
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Keywords
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Gene Ontology
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| GO:0005509; Molecular function:calcium ion binding |
Features
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| From: PS51234 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REPEAT | from | to | /note="TSP type-3 #" | |||||||||
Additional information
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| Size range | 13-53 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 8 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [23] All [ 23 ]
- Retrieve set of proteins with 3D structure for this domain