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	Entry: PS51234

General information about the entry

Entry name [info]

TSP3

Accession [info]

PS51234

Entry type [info]

MATRIX

Date [info]

01-MAR-2007 CREATED;
01-OCT-2013 DATA UPDATE;
12-AUG-2020 INFO UPDATE.

PROSITE Doc. [info]

PDOC51234

Associated ProRule [info]

PRU00634

Name and characterization of the entry

Description [info]

Thrombospondin type-3 (TSP3) repeat profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=36;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=36;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8454413; R2=0.0060809; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=2164; N_SCORE=15.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=766; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-33; D=-120; I=-120; B1=-200; E1=-200; MI=-305; MD=-305; IM=-305; DM=-305;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-305; BD=-305;
/M: SY='E';  M= -20,  12,  13,  50, -41, -50, -41, -19,  36,  -5, -18, -20, -49,  11,  30, -25,   8, -38, -61, -21;
/M: SY='D';  M= -51, -64, 108, -17, -70, -47, -37, -66, -39, -67, -65,  22,  -6, -38, -47, -39, -40, -43, -85, -54;
/M: SY='T';  M=  12, -49,   4, -42,   4, -32,  -1, -41, -14, -47, -21, -19, -49, -42, -17,  42,  62,  10, -62, -13;
/M: SY='D';  M= -50, -63, 106,  -8, -70, -30, -36, -68, -38, -68, -65,  33,  -6, -38, -47, -38, -40, -66, -84, -55;
/M: SY='G';  M=  -8, -58, -43,  -1, -56,  58, -46, -33,  13,  -2, -38,  11, -53, -15,  28,   9, -32, -34, -60, -52;
/M: SY='D';  M= -50, -61, 103, -19, -69, -45, -34, -68, -37, -68, -64,  58, -52, -37, -45, -37, -38, -66, -85, -54;
/M: SY='G';  M= -35, -60, -12, -43, -65,  90, -52, -39, -12, -61, -56, -24, -52, -33, -12, -19, -39, -63, -58, -59;
/M: SY='W';  M= -37, -59, -54,   3,  -2, -62,  10,  19,   3,  -4,  -5, -51, -57,   2,  23, -40, -15,  44,  81,  -3;
/M: SY='G';  M= -38,-123, -97,-113,-133, 185,-108,-143,-103,-138,-116, -72,  55,-100, -76, -68,-101,-132,-116,-123;
/M: SY='D';  M= -51, -63, 109, -17, -71, -46, -36, -69, -38, -68, -66,  31, -51, -37, -46, -38, -40, -66, -86, -54;
/I:         I=-31; MI=0; MD=-78; IM=0; DM=-78;
/M: SY='A';  M=  66, -49, -41, -24, -51, -19, -43,   5, -21, -19, -22, -47, -52, -27, -30,  -2,  -9,  28, -62, -50;
/M: SY='C';  M= -90, 298,-129,-130,-110,-121,-129,-124,-121,-105,-106,-102,-151,-137,-134, -95, -90, -99,-170,-132;
/I:         I=-17; MD=-44;
/M: SY='D';  M= -37, -81,  67,  37, -85, -70, -58, -44, -17, -79, -76, -46, -66, -15, -59, -39, -35, -76, -92, -72; D=-17;
/I:         I=-17; MI=-44; MD=-44; IM=-44; DM=-44;
/M: SY='D';  M= -41, -76,  41,  -9, -57,  -7, -62, -71, -21, -48, -69, -11,  -6, -58, -49, -11,  18, -37, -85, -28; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -69, -83,  92, -34, -88, -66, -55, -87, -54, -85, -83, -38, -22, -55, -15, -57, -59, -83,-101, -71; D=-17;
/I:         I=-17; DM=-44;
/M: SY='F';  M=   4, -69,   5, -28,  60, -37, -62,   9, -65, -40,  -8, -62, -72, -48, -49, -32, -57, -16, -55,   5; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -63,  13,  94, -32, -83, -62, -52, -81, -53, -80, -78, -34, -65, -53, -62, -27, -17, -77, -99, -68; D=-17;
/I:         I=-17; DM=-44;
/M: SY='N';  M= -44, -69, -17, -57, -71,  37, -32, -67, -19, -24, -29,  68, -69,  -4, -58, -47, -53, -36, -80, -67; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -14, -73,  92, -31, -79, -59, -52, -71, -31, -74, -72, -35, -28, -51, -58, -49, -23, -27, -93, -65; D=-17;
/I:         I=-17; DM=-44;
/M: SY='G';  M= -34, -66, -13, -33, -71,  45, -58, -70,   6, -42, -62,   4, -61, -30, -37,  19,  25, -65, -75, -65; D=-17;
/I:         I=-17; DM=-44;
/M: SY='I';  M= -57, -69, -73, -73, -32, -78, -69,  61, -68, -13, -36, -11, -30, -67, -46, -51, -51,  38, -66,  15; D=-17;
/I:         I=-17; DM=-44;
/M: SY='P';  M= -50, -73, -17, -36, -33, -67,  26,   4, -25,  -8,   4, -28,  58, -23, -22, -25,  -6, -11, -74, -38; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -60,  46,  70,  -9, -76, -56, -47, -77, -47, -77, -71,  61, -66, -48, -17, -39, -49, -74, -93, -67; D=-17;
/I:         I=-17; DM=-44;
/M: SY='I';  M= -16, -70,  -2,   8, -42, -18,   2,  17, -23,  -9, -39, -35, -18, -22,   3, -14,  -2, -28, -71, -15; D=-17;
/I:         I=-17; DM=-44;
/M: SY='K';  M= -32, -71,  13,   1, -34, -61, -57,   3,  16,   5,  -1, -54,  -4,   5,   7, -35, -35, -17, -70, -32; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -52, -65, 113, -15, -72, -48, -37, -70, -39, -68, -67, -19, -51, -38, -47, -39, -41, -67, -87, -54;
/M: SY='N';  M= -13, -51,   2, -41, -57, -38,  14, -36, -36, -57, -48, 103, -56, -37, -43,  -2, -26,  12, -77, -52;
/M: SY='C';  M= -90, 298,-129,-130,-110,-121,-129,-124,-121,-105,-106,-102,-151,-137,-134, -95, -90, -99,-170,-132;
/M: SY='P';  M= -48, -69, -53, -42, -57, -47, -53,   0, -43, -15, -23, -55, 105,  -4,   8, -38, -43,  -6,  15, -56;
/M: SY='E';  M= -19, -57,   8,  44, -17, -54, -21, -38,  21,  25, -17,  21, -52, -20,   3,  -1, -16, -38, -54,  25;
/M: SY='N';  M= -24, -53, -33, -27, -39, -52, -28,  12, -23,  15, -17,  61,  -4, -26, -49,  -3,  -7,  47, -67, -47;
/M: SY='P';  M=  30, -58, -33, -27, -12, -47,   4, -42,  11, -36, -45,  -2,  73, -41, -21,  15, -31, -14, -54,  28;
/M: SY='N';  M= -32, -53,  -1,  30, -61, -26, -30, -59,  -6, -63,  -3, 103, -53, -31, -38,  -6, -33, -59, -74, -55;
/M: SY='P';  M= -21, -59, -22, -47, -22, -26, -54,  33, -42, -37, -39, -19,  72, -38, -31,  31,  -8,  30, -63, -50;
/M: SY='D';  M= -27, -56,  58, -21,   3,  28,  32, -55, -35, -32,  -8,  18, -51, -28, -21,  12,  36, -52, -66, -30;
/M: SY='Q';  M= -22, -62, -30,  -2, -58, -53,   6, -46, -23,  10,  -5, -38, -52, 105, -31, -20,  -1, -26, -58, -43;
/I:         E1=0; IE=-305; DE=-305;

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Post-processing [info]

COMPETES_HIT_WITH

PS51236

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2020_04 which contains 563'082 sequence entries.

Total number of hits

176 in 22 different sequences

Number of true positive hits

176 in 22 different sequences

Number of 'unknown' hits

Number of false positive hits

Number of false negative sequences

Number of 'partial' sequences

Precision (true positives / (true positives + false positives))

100.00 %

Recall (true positives / (true positives + false negatives))

99.44 %

Comments [info]

Matrix type [info]

protein_domain

Scaling database [info]

reversed

Author [info]

N_Hulo

Taxonomic range [info]

Eukaryotes

Maximum number of repetitions [info]

Feature key [info]

REPEAT

Feature description [info]

TSP type-3

Version [info]

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

22 sequences

COMP_BOVIN  (P35445    ), COMP_HUMAN  (P49747    ), COMP_MOUSE  (Q9R0G6    ),

COMP_RAT    (P35444    ), TSP1_BOVIN  (Q28178    ), TSP1_HUMAN  (P07996    ), 
TSP1_MOUSE  (P35441    ), TSP1_XENLA  (P35448    ), TSP2_BOVIN  (Q95116    ), 
TSP2_CHICK  (P35440    ), TSP2_HUMAN  (P35442    ), TSP2_MOUSE  (Q03350    ), 
TSP3A_DANRE (Q8JHW2    ), TSP3B_DANRE (Q1L8P7    ), TSP3_HUMAN  (P49746    ), 
TSP3_MOUSE  (Q05895    ), TSP4B_DANRE (Q8JGW0    ), TSP4_BOVIN  (Q3SWW8    ), 
TSP4_HUMAN  (P35443    ), TSP4_MOUSE  (Q9Z1T2    ), TSP4_RAT    (P49744    ), 
TSP4_XENLA  (Q06441    )

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

1 sequence

ARP_EUGGR   (Q04732    )

PDB
[Detailed view]

4 PDB

1UX6; 1YO8; 2RHP; 3FBY

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