We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS51234

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PURL: https://purl.expasy.org/prosite/signature/PS51234

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General information about the entry

Entry name [info]	TSP3
Accession [info]	PS51234
Entry type [info]	MATRIX
Date [info]	01-MAR-2007 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51234
Associated ProRule [info]	PRU00634

Name and characterization of the entry

Description [info]

Thrombospondin type-3 (TSP3) repeat profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=36;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=36;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8454413; R2=0.0060809; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=2164; N_SCORE=15.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=766; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-33; D=-120; I=-120; B1=-200; E1=-200; MI=-305; MD=-305; IM=-305; DM=-305;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-305; BD=-305;
/M: SY='E';  M= -20,  12,  13,  50, -41, -50, -41, -19,  36,  -5, -18, -20, -49,  11,  30, -25,   8, -38, -61, -21;
/M: SY='D';  M= -51, -64, 108, -17, -70, -47, -37, -66, -39, -67, -65,  22,  -6, -38, -47, -39, -40, -43, -85, -54;
/M: SY='T';  M=  12, -49,   4, -42,   4, -32,  -1, -41, -14, -47, -21, -19, -49, -42, -17,  42,  62,  10, -62, -13;
/M: SY='D';  M= -50, -63, 106,  -8, -70, -30, -36, -68, -38, -68, -65,  33,  -6, -38, -47, -38, -40, -66, -84, -55;
/M: SY='G';  M=  -8, -58, -43,  -1, -56,  58, -46, -33,  13,  -2, -38,  11, -53, -15,  28,   9, -32, -34, -60, -52;
/M: SY='D';  M= -50, -61, 103, -19, -69, -45, -34, -68, -37, -68, -64,  58, -52, -37, -45, -37, -38, -66, -85, -54;
/M: SY='G';  M= -35, -60, -12, -43, -65,  90, -52, -39, -12, -61, -56, -24, -52, -33, -12, -19, -39, -63, -58, -59;
/M: SY='W';  M= -37, -59, -54,   3,  -2, -62,  10,  19,   3,  -4,  -5, -51, -57,   2,  23, -40, -15,  44,  81,  -3;
/M: SY='G';  M= -38,-123, -97,-113,-133, 185,-108,-143,-103,-138,-116, -72,  55,-100, -76, -68,-101,-132,-116,-123;
/M: SY='D';  M= -51, -63, 109, -17, -71, -46, -36, -69, -38, -68, -66,  31, -51, -37, -46, -38, -40, -66, -86, -54;
/I:         I=-31; MI=0; MD=-78; IM=0; DM=-78;
/M: SY='A';  M=  66, -49, -41, -24, -51, -19, -43,   5, -21, -19, -22, -47, -52, -27, -30,  -2,  -9,  28, -62, -50;
/M: SY='C';  M= -90, 298,-129,-130,-110,-121,-129,-124,-121,-105,-106,-102,-151,-137,-134, -95, -90, -99,-170,-132;
/I:         I=-17; MD=-44;
/M: SY='D';  M= -37, -81,  67,  37, -85, -70, -58, -44, -17, -79, -76, -46, -66, -15, -59, -39, -35, -76, -92, -72; D=-17;
/I:         I=-17; MI=-44; MD=-44; IM=-44; DM=-44;
/M: SY='D';  M= -41, -76,  41,  -9, -57,  -7, -62, -71, -21, -48, -69, -11,  -6, -58, -49, -11,  18, -37, -85, -28; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -69, -83,  92, -34, -88, -66, -55, -87, -54, -85, -83, -38, -22, -55, -15, -57, -59, -83,-101, -71; D=-17;
/I:         I=-17; DM=-44;
/M: SY='F';  M=   4, -69,   5, -28,  60, -37, -62,   9, -65, -40,  -8, -62, -72, -48, -49, -32, -57, -16, -55,   5; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -63,  13,  94, -32, -83, -62, -52, -81, -53, -80, -78, -34, -65, -53, -62, -27, -17, -77, -99, -68; D=-17;
/I:         I=-17; DM=-44;
/M: SY='N';  M= -44, -69, -17, -57, -71,  37, -32, -67, -19, -24, -29,  68, -69,  -4, -58, -47, -53, -36, -80, -67; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -14, -73,  92, -31, -79, -59, -52, -71, -31, -74, -72, -35, -28, -51, -58, -49, -23, -27, -93, -65; D=-17;
/I:         I=-17; DM=-44;
/M: SY='G';  M= -34, -66, -13, -33, -71,  45, -58, -70,   6, -42, -62,   4, -61, -30, -37,  19,  25, -65, -75, -65; D=-17;
/I:         I=-17; DM=-44;
/M: SY='I';  M= -57, -69, -73, -73, -32, -78, -69,  61, -68, -13, -36, -11, -30, -67, -46, -51, -51,  38, -66,  15; D=-17;
/I:         I=-17; DM=-44;
/M: SY='P';  M= -50, -73, -17, -36, -33, -67,  26,   4, -25,  -8,   4, -28,  58, -23, -22, -25,  -6, -11, -74, -38; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -60,  46,  70,  -9, -76, -56, -47, -77, -47, -77, -71,  61, -66, -48, -17, -39, -49, -74, -93, -67; D=-17;
/I:         I=-17; DM=-44;
/M: SY='I';  M= -16, -70,  -2,   8, -42, -18,   2,  17, -23,  -9, -39, -35, -18, -22,   3, -14,  -2, -28, -71, -15; D=-17;
/I:         I=-17; DM=-44;
/M: SY='K';  M= -32, -71,  13,   1, -34, -61, -57,   3,  16,   5,  -1, -54,  -4,   5,   7, -35, -35, -17, -70, -32; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -52, -65, 113, -15, -72, -48, -37, -70, -39, -68, -67, -19, -51, -38, -47, -39, -41, -67, -87, -54;
/M: SY='N';  M= -13, -51,   2, -41, -57, -38,  14, -36, -36, -57, -48, 103, -56, -37, -43,  -2, -26,  12, -77, -52;
/M: SY='C';  M= -90, 298,-129,-130,-110,-121,-129,-124,-121,-105,-106,-102,-151,-137,-134, -95, -90, -99,-170,-132;
/M: SY='P';  M= -48, -69, -53, -42, -57, -47, -53,   0, -43, -15, -23, -55, 105,  -4,   8, -38, -43,  -6,  15, -56;
/M: SY='E';  M= -19, -57,   8,  44, -17, -54, -21, -38,  21,  25, -17,  21, -52, -20,   3,  -1, -16, -38, -54,  25;
/M: SY='N';  M= -24, -53, -33, -27, -39, -52, -28,  12, -23,  15, -17,  61,  -4, -26, -49,  -3,  -7,  47, -67, -47;
/M: SY='P';  M=  30, -58, -33, -27, -12, -47,   4, -42,  11, -36, -45,  -2,  73, -41, -21,  15, -31, -14, -54,  28;
/M: SY='N';  M= -32, -53,  -1,  30, -61, -26, -30, -59,  -6, -63,  -3, 103, -53, -31, -38,  -6, -33, -59, -74, -55;
/M: SY='P';  M= -21, -59, -22, -47, -22, -26, -54,  33, -42, -37, -39, -19,  72, -38, -31,  31,  -8,  30, -63, -50;
/M: SY='D';  M= -27, -56,  58, -21,   3,  28,  32, -55, -35, -32,  -8,  18, -51, -28, -21,  12,  36, -52, -66, -30;
/M: SY='Q';  M= -22, -62, -30,  -2, -58, -53,   6, -46, -23,  10,  -5, -38, -52, 105, -31, -20,  -1, -26, -58, -43;
/I:         E1=0; IE=-305; DE=-305;

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Post-processing [info]

COMPETES_HIT_WITH

PS51236

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	176 in 22 different sequences
Number of true positive hits	176 in 22 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	1
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	99.44 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	8
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	N_Hulo
Feature key [info]	REPEAT
Feature description [info]	TSP type-3
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

22 sequences

COMP_BOVIN  (P35445), COMP_HUMAN  (P49747), COMP_MOUSE  (Q9R0G6),

COMP_RAT(P35444), TSP1_BOVIN  (Q28178), TSP1_HUMAN  (P07996), 
TSP1_MOUSE  (P35441), TSP1_XENLA  (P35448), TSP2_BOVIN  (Q95116), 
TSP2_CHICK  (P35440), TSP2_HUMAN  (P35442), TSP2_MOUSE  (Q03350), 
TSP3A_DANRE (Q8JHW2), TSP3B_DANRE (Q1L8P7), TSP3_HUMAN  (P49746), 
TSP3_MOUSE  (Q05895), TSP4B_DANRE (Q8JGW0), TSP4_BOVIN  (Q3SWW8), 
TSP4_HUMAN  (P35443), TSP4_MOUSE  (Q9Z1T2), TSP4_RAT(P49744), 
TSP4_XENLA  (Q06441)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

1 sequence

ARP_EUGGR   (Q04732)

PDB
[Detailed view]

4 PDB

pdb_00001ux6; pdb_00001yo8; pdb_00002rhp; pdb_00003fby