PROSITE entry PS51234

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General information about the entry

Entry name [info]	TSP3
Accession [info]	PS51234
Entry type [info]	MATRIX
Date [info]	01-MAR-2007 CREATED; 01-OCT-2013 DATA UPDATE; 08-NOV-2023 INFO UPDATE.
PROSITE Doc. [info]	PDOC51234
Associated ProRule [info]	PRU00634

Name and characterization of the entry

Description [info]

Thrombospondin type-3 (TSP3) repeat profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=36;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=36;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8454413; R2=0.0060809; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=2164; N_SCORE=15.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=766; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-33; D=-120; I=-120; B1=-200; E1=-200; MI=-305; MD=-305; IM=-305; DM=-305;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-305; BD=-305;
/M: SY='E';  M= -20,  12,  13,  50, -41, -50, -41, -19,  36,  -5, -18, -20, -49,  11,  30, -25,   8, -38, -61, -21;
/M: SY='D';  M= -51, -64, 108, -17, -70, -47, -37, -66, -39, -67, -65,  22,  -6, -38, -47, -39, -40, -43, -85, -54;
/M: SY='T';  M=  12, -49,   4, -42,   4, -32,  -1, -41, -14, -47, -21, -19, -49, -42, -17,  42,  62,  10, -62, -13;
/M: SY='D';  M= -50, -63, 106,  -8, -70, -30, -36, -68, -38, -68, -65,  33,  -6, -38, -47, -38, -40, -66, -84, -55;
/M: SY='G';  M=  -8, -58, -43,  -1, -56,  58, -46, -33,  13,  -2, -38,  11, -53, -15,  28,   9, -32, -34, -60, -52;
/M: SY='D';  M= -50, -61, 103, -19, -69, -45, -34, -68, -37, -68, -64,  58, -52, -37, -45, -37, -38, -66, -85, -54;
/M: SY='G';  M= -35, -60, -12, -43, -65,  90, -52, -39, -12, -61, -56, -24, -52, -33, -12, -19, -39, -63, -58, -59;
/M: SY='W';  M= -37, -59, -54,   3,  -2, -62,  10,  19,   3,  -4,  -5, -51, -57,   2,  23, -40, -15,  44,  81,  -3;
/M: SY='G';  M= -38,-123, -97,-113,-133, 185,-108,-143,-103,-138,-116, -72,  55,-100, -76, -68,-101,-132,-116,-123;
/M: SY='D';  M= -51, -63, 109, -17, -71, -46, -36, -69, -38, -68, -66,  31, -51, -37, -46, -38, -40, -66, -86, -54;
/I:         I=-31; MI=0; MD=-78; IM=0; DM=-78;
/M: SY='A';  M=  66, -49, -41, -24, -51, -19, -43,   5, -21, -19, -22, -47, -52, -27, -30,  -2,  -9,  28, -62, -50;
/M: SY='C';  M= -90, 298,-129,-130,-110,-121,-129,-124,-121,-105,-106,-102,-151,-137,-134, -95, -90, -99,-170,-132;
/I:         I=-17; MD=-44;
/M: SY='D';  M= -37, -81,  67,  37, -85, -70, -58, -44, -17, -79, -76, -46, -66, -15, -59, -39, -35, -76, -92, -72; D=-17;
/I:         I=-17; MI=-44; MD=-44; IM=-44; DM=-44;
/M: SY='D';  M= -41, -76,  41,  -9, -57,  -7, -62, -71, -21, -48, -69, -11,  -6, -58, -49, -11,  18, -37, -85, -28; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -69, -83,  92, -34, -88, -66, -55, -87, -54, -85, -83, -38, -22, -55, -15, -57, -59, -83,-101, -71; D=-17;
/I:         I=-17; DM=-44;
/M: SY='F';  M=   4, -69,   5, -28,  60, -37, -62,   9, -65, -40,  -8, -62, -72, -48, -49, -32, -57, -16, -55,   5; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -63,  13,  94, -32, -83, -62, -52, -81, -53, -80, -78, -34, -65, -53, -62, -27, -17, -77, -99, -68; D=-17;
/I:         I=-17; DM=-44;
/M: SY='N';  M= -44, -69, -17, -57, -71,  37, -32, -67, -19, -24, -29,  68, -69,  -4, -58, -47, -53, -36, -80, -67; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -14, -73,  92, -31, -79, -59, -52, -71, -31, -74, -72, -35, -28, -51, -58, -49, -23, -27, -93, -65; D=-17;
/I:         I=-17; DM=-44;
/M: SY='G';  M= -34, -66, -13, -33, -71,  45, -58, -70,   6, -42, -62,   4, -61, -30, -37,  19,  25, -65, -75, -65; D=-17;
/I:         I=-17; DM=-44;
/M: SY='I';  M= -57, -69, -73, -73, -32, -78, -69,  61, -68, -13, -36, -11, -30, -67, -46, -51, -51,  38, -66,  15; D=-17;
/I:         I=-17; DM=-44;
/M: SY='P';  M= -50, -73, -17, -36, -33, -67,  26,   4, -25,  -8,   4, -28,  58, -23, -22, -25,  -6, -11, -74, -38; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -60,  46,  70,  -9, -76, -56, -47, -77, -47, -77, -71,  61, -66, -48, -17, -39, -49, -74, -93, -67; D=-17;
/I:         I=-17; DM=-44;
/M: SY='I';  M= -16, -70,  -2,   8, -42, -18,   2,  17, -23,  -9, -39, -35, -18, -22,   3, -14,  -2, -28, -71, -15; D=-17;
/I:         I=-17; DM=-44;
/M: SY='K';  M= -32, -71,  13,   1, -34, -61, -57,   3,  16,   5,  -1, -54,  -4,   5,   7, -35, -35, -17, -70, -32; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -52, -65, 113, -15, -72, -48, -37, -70, -39, -68, -67, -19, -51, -38, -47, -39, -41, -67, -87, -54;
/M: SY='N';  M= -13, -51,   2, -41, -57, -38,  14, -36, -36, -57, -48, 103, -56, -37, -43,  -2, -26,  12, -77, -52;
/M: SY='C';  M= -90, 298,-129,-130,-110,-121,-129,-124,-121,-105,-106,-102,-151,-137,-134, -95, -90, -99,-170,-132;
/M: SY='P';  M= -48, -69, -53, -42, -57, -47, -53,   0, -43, -15, -23, -55, 105,  -4,   8, -38, -43,  -6,  15, -56;
/M: SY='E';  M= -19, -57,   8,  44, -17, -54, -21, -38,  21,  25, -17,  21, -52, -20,   3,  -1, -16, -38, -54,  25;
/M: SY='N';  M= -24, -53, -33, -27, -39, -52, -28,  12, -23,  15, -17,  61,  -4, -26, -49,  -3,  -7,  47, -67, -47;
/M: SY='P';  M=  30, -58, -33, -27, -12, -47,   4, -42,  11, -36, -45,  -2,  73, -41, -21,  15, -31, -14, -54,  28;
/M: SY='N';  M= -32, -53,  -1,  30, -61, -26, -30, -59,  -6, -63,  -3, 103, -53, -31, -38,  -6, -33, -59, -74, -55;
/M: SY='P';  M= -21, -59, -22, -47, -22, -26, -54,  33, -42, -37, -39, -19,  72, -38, -31,  31,  -8,  30, -63, -50;
/M: SY='D';  M= -27, -56,  58, -21,   3,  28,  32, -55, -35, -32,  -8,  18, -51, -28, -21,  12,  36, -52, -66, -30;
/M: SY='Q';  M= -22, -62, -30,  -2, -58, -53,   6, -46, -23,  10,  -5, -38, -52, 105, -31, -20,  -1, -26, -58, -43;
/I:         E1=0; IE=-305; DE=-305;

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Post-processing [info]

COMPETES_HIT_WITH

PS51236

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_05 which contains 570'420 sequence entries.

Total number of hits	176 in 22 different sequences
Number of true positive hits	176 in 22 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	1
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	99.44 %

Comments [info]

Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	N_Hulo
Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	8
Feature key [info]	REPEAT
Feature description [info]	TSP type-3
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

22 sequences

COMP_BOVIN  (P35445), COMP_HUMAN  (P49747), COMP_MOUSE  (Q9R0G6),

COMP_RAT(P35444), TSP1_BOVIN  (Q28178), TSP1_HUMAN  (P07996), 
TSP1_MOUSE  (P35441), TSP1_XENLA  (P35448), TSP2_BOVIN  (Q95116), 
TSP2_CHICK  (P35440), TSP2_HUMAN  (P35442), TSP2_MOUSE  (Q03350), 
TSP3A_DANRE (Q8JHW2), TSP3B_DANRE (Q1L8P7), TSP3_HUMAN  (P49746), 
TSP3_MOUSE  (Q05895), TSP4B_DANRE (Q8JGW0), TSP4_BOVIN  (Q3SWW8), 
TSP4_HUMAN  (P35443), TSP4_MOUSE  (Q9Z1T2), TSP4_RAT(P49744), 
TSP4_XENLA  (Q06441)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

1 sequence

ARP_EUGGR   (Q04732)

PDB
[Detailed view]

4 PDB

1UX6; 1YO8; 2RHP; 3FBY