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annotation rule: PRU00652

General rule information [?]

Accession PRU00652
Dates 16-DEC-2010 (Created)
21-NOV-2019 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51322; UEV
Name UEV domain
Function The N-terminal ubiquitin E2 variant (UEV) domain is ~145 amino acid residues in length and shows significant sequence similarity to E2 ubiquitin ligases but is unable to catalyze ubiquitin transfer as it lacks the active site cysteine that forms the transient thioester bond with the C-terminus of ubiquitin (Ub). Nevertheless, at least some UEVs have retained the ability to bind Ub, and appear to act either as cofactors in ubiquitylation reactions, or as ubiquitin sensors.

Propagated annotation [?]


Features [?]

From: PS51322
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       UEV #        

Additional information [?]

Size range 134-160 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9LHG8 (ELC_ARATH)
Scope
Eukaryota
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]