ProRule PRU00652
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00652 |
| Accession | PRU00652 |
| Dates | 16-DEC-2010 (Created)
21-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51322; UEV |
Name | UEV domain |
| Function | The N-terminal ubiquitin E2 variant (UEV) domain is ~145 amino acid residues in length and shows significant sequence similarity to E2 ubiquitin ligases but is unable to catalyze ubiquitin transfer as it lacks the active site cysteine that forms the transient thioester bond with the C-terminus of ubiquitin (Ub). Nevertheless, at least some UEVs have retained the ability to bind Ub, and appear to act either as cofactors in ubiquitylation reactions, or as ubiquitin sensors. |
| Scope(s) |
Eukaryota |
| Example(s) | Q9LHG8 (ELC_ARATH); |
Propagated annotation
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Features
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| From: PS51322 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="UEV #" | |||||||||
Additional information
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| Size range | 134-160 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [11] All [ 11 ]
- Retrieve set of proteins with 3D structure for this domain