ProRule PRU00652

General rule information [?]

Accession PRU00652
Dates 16-DEC-2010 (Created)
21-NOV-2019 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51322; UEV
Name UEV domain
Function The N-terminal ubiquitin E2 variant (UEV) domain is ~145 amino acid residues in length and shows significant sequence similarity to E2 ubiquitin ligases but is unable to catalyze ubiquitin transfer as it lacks the active site cysteine that forms the transient thioester bond with the C-terminus of ubiquitin (Ub). Nevertheless, at least some UEVs have retained the ability to bind Ub, and appear to act either as cofactors in ubiquitylation reactions, or as ubiquitin sensors.
Scope(s) Eukaryota
Example(s) Q9LHG8 (ELC_ARATH);

Propagated annotation [?]

Features [?]

From: PS51322
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="UEV #"

Additional information [?]

Size range 134-160 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]