ProRule PRU00656

Accession	PRU00656
Dates	05-DEC-2007 (Created) 26-JUN-2023 (Last updated, Version 7)
Data class	Domain;
Predictors	PROSITE; PS51326; AVIDIN_2
Name	Avidin-like domain
Function	Avidin and streptavidin both form homotetrameric complexes of noncovalently associated chains. Each chain forms a very strong and specific non-covalent complex with one molecule of biotin. The dimeric bacterial avidin sub-family members that bind biotin with high affinity exhibit a dimeric (1-4 dimer) rather than a tetrameric structure. The fibropellin avidin-like domain forms a homotetramer incapable of binding biotin.
Scope(s)	Eukaryota Bacteria Archaea
Example(s)	P02701;

From: PS51326
Key	From	To	Description	Tag	Condition	FTGroup
DOMAIN	from	to	/note="Avidin-like #"
case <OC:Eukaryota> and <AnyFeature:PS51326:104=W>
BINDING	31	31	/ligand="biotin" /ligand_id="ChEBI:CHEBI:57586"	biotin	Y
else case <OC:Bacteria>
BINDING	31	31	/ligand="biotin" /ligand_id="ChEBI:CHEBI:57586"	biotin	Y	1
BINDING	45	45	/ligand="biotin" /ligand_id="ChEBI:CHEBI:57586"	biotin	Y	1
BINDING	75	75	/ligand="biotin" /ligand_id="ChEBI:CHEBI:57586"	biotin	W	1
BINDING	92	92	/ligand="biotin" /ligand_id="ChEBI:CHEBI:57586"	biotin	W	1
BINDING	104	104	/ligand="biotin" /ligand_id="ChEBI:CHEBI:57586"	biotin	W	1
end case
DISULFID	3	79		disulf	C-x*-C
DISULFID	40	69		disulf	C-x*-C