We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00656
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00656
General rule information
[?]
| Accession | PRU00656 |
| Dates | 05-DEC-2007 (Created)
26-JUN-2023 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51326; AVIDIN_2 |
Name | Avidin-like domain |
| Function | Avidin and streptavidin both form homotetrameric complexes of noncovalently associated chains. Each chain forms a very strong and specific non-covalent complex with one molecule of biotin. The dimeric bacterial avidin sub-family members that bind biotin with high affinity exhibit a dimeric (1-4 dimer) rather than a tetrameric structure. The fibropellin avidin-like domain forms a homotetramer incapable of binding biotin. |
| Scope(s) |
Eukaryota Bacteria Archaea |
| Example(s) | P02701; |
Propagated annotation
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Comments
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| case not <AnyFeature:PS51326:40-69=C-x*-C> | |
| SUBUNIT | Homotetramer. |
| end case | |
| SUBCELLULAR LOCATION | Secreted. |
Keywords
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| Biotin | |
| end case | |
| Secreted | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| case <FTTag:biotin> or <AnyFeature:PS51326:40-69=C-x*-C> | |
| GO:0009374; Molecular function:biotin binding | |
Cross-references
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| PROSITE | PS00577; AVIDIN_1; 1; |
Features
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| From: PS51326 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Avidin-like #" | |||||||||
| case <OC:Eukaryota> and <AnyFeature:PS51326:104=W> | ||||||||||||
| BINDING | 31 | 31 | /ligand="biotin" /ligand_id="ChEBI:CHEBI:57586" |
biotin | Y | |||||||
| else case <OC:Bacteria> | ||||||||||||
| BINDING | 31 | 31 | /ligand="biotin" /ligand_id="ChEBI:CHEBI:57586" |
biotin | Y | 1 | ||||||
| BINDING | 45 | 45 | /ligand="biotin" /ligand_id="ChEBI:CHEBI:57586" |
biotin | Y | 1 | ||||||
| BINDING | 75 | 75 | /ligand="biotin" /ligand_id="ChEBI:CHEBI:57586" |
biotin | W | 1 | ||||||
| BINDING | 92 | 92 | /ligand="biotin" /ligand_id="ChEBI:CHEBI:57586" |
biotin | W | 1 | ||||||
| BINDING | 104 | 104 | /ligand="biotin" /ligand_id="ChEBI:CHEBI:57586" |
biotin | W | 1 | ||||||
| end case | ||||||||||||
| DISULFID | 3 | 79 | disulf | C-x*-C | ||||||||
| DISULFID | 40 | 69 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 115-125 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Not cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [5] Eukaryota [9] All [ 14 ]
- Retrieve set of proteins with 3D structure for this domain