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annotation rule: PRU00660

General rule information [?]

Accession PRU00660
Dates 21-APR-2009 (Created)
11-JAN-2021 (Last updated, Version 7)
Data class Domain
Predictors PROSITE; PS51330; DHFR_2
Name Dihydrofolate reductase (DHFR) domain
Function Dihydrofolate reductases (DHFRs) (EC are ubiquitous enzymes which catalyze the NADPH-linked reduction of 7,8-dihydrofolate to 5,6,7,8- tetrahydrofolate.

Propagated annotation [?]

Description [?]

+ RecName: EC;

Comments [?]

Catalytic activity RHEA:15009: (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH

Cross-references [?]

PROSITE PS00075; DHFR_1; 1;

Gene Ontology [?]

GO:0016491; Molecular function: oxidoreductase activity.
GO:0004146; Molecular function: dihydrofolate reductase activity.
GO:0050661; Molecular function: NADP binding.

Keywords [?]

Features [?]

From: PS51330
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       DHFR #        

Additional information [?]

Size range 145-257 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q5V3R2 (DYR1_HALMA)
Comments None


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UniProtKB rule member sequences [?]