PRU00660
General rule information
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Accession | PRU00660 |
Dates | 21-APR-2009 (Created) 11-JAN-2021 (Last updated, Version 7) |
Data class | Domain |
Predictors | PROSITE; PS51330; DHFR_2 |
Name | Dihydrofolate reductase (DHFR) domain |
Function | Dihydrofolate reductases (DHFRs) (EC 1.5.1.3) are ubiquitous enzymes which catalyze the NADPH-linked reduction of 7,8-dihydrofolate to 5,6,7,8- tetrahydrofolate. |
Propagated annotation
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Description
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+ RecName: EC 1.5.1.3; |
Comments
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Catalytic activity | RHEA:15009: (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH
EC 1.5.1.3 |
Cross-references
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PROSITE | PS00075; DHFR_1; 1; |
Gene Ontology
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GO:0016491; Molecular function: oxidoreductase activity.
GO:0004146; Molecular function: dihydrofolate reductase activity.
GO:0050661; Molecular function: NADP binding.
GO:0004146; Molecular function: dihydrofolate reductase activity.
GO:0050661; Molecular function: NADP binding.
Keywords
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Features
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From: PS51330 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | DHFR # |
Additional information
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Size range | 145-257 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q5V3R2 (DYR1_HALMA) |
Scope | Bacteria
Eukaryota
Viruses
Archaea |
Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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