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annotation rule: PRU00660

General rule information [?]

Accession PRU00660
Dates 21-APR-2009 (Created)
27-OCT-2018 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS51330; DHFR_2
Name Dihydrofolate reductase (DHFR) domain
Function Dihydrofolate reductases (DHFRs) (EC 1.5.1.3) are ubiquitous enzymes which catalyze the NADPH-linked reduction of 7,8-dihydrofolate to 5,6,7,8- tetrahydrofolate.

Propagated annotation [?]


Description [?]

+ RecName: EC=1.5.1.3;

Comments [?]

Catalytic activity Reaction=(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8- dihydrofolate + H(+) + NADPH; Xref=Rhea:RHEA:15009, ChEBI:CHEBI:15378, ChEBI:CHEBI:57451, ChEBI:CHEBI:57453, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.3;.

Cross-references [?]

PROSITE PS00075; DHFR_1; 1;

Gene Ontology [?]

GO:0004146; Molecular function: dihydrofolate reductase activity.
GO:0055114; Biological process: oxidation-reduction process.
GO:0050661; Molecular function: NADP binding.

Keywords [?]


Features [?]

From: PS51330
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       DHFR #        

Additional information [?]

Size range 145-257 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q5V3R2 (DYR1_HALMA)
Scope
Bacteria
Eukaryota
Viruses
Archaea
Comments None

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]