We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00660
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00660
General rule information
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| Accession | PRU00660 |
| Dates | 21-APR-2009 (Created)
03-SEP-2024 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51330; DHFR_2 |
Name | Dihydrofolate reductase (DHFR) domain |
| Function | Dihydrofolate reductases (DHFRs) (EC 1.5.1.3) are ubiquitous enzymes which catalyze the NADPH-linked reduction of 7,8-dihydrofolate to 5,6,7,8- tetrahydrofolate. |
| Scope(s) |
Bacteria Eukaryota Viruses Archaea |
| Example(s) | Q5V3R2; |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=1.5.1.3; |
Comments
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| CATALYTIC ACTIVITY | Reaction=(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+); Xref=Rhea:RHEA:15009, ChEBI:CHEBI:15378, ChEBI:CHEBI:57451, ChEBI:CHEBI:57453, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.3; |
Keywords
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Gene Ontology
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| GO:0016491; Molecular function:oxidoreductase activity |
| GO:0004146; Molecular function:dihydrofolate reductase activity |
| GO:0050661; Molecular function:NADP binding |
Cross-references
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| PROSITE | PS00075; DHFR_1; 1; |
Features
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| From: PS51330 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="DHFR #" | |||||||||
Additional information
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| Size range | 145-257 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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