PRU00660

Accession	PRU00660
Dates	21-APR-2009 (Created) 11-JAN-2021 (Last updated, Version 7)

Data class

Domain

Predictors

PROSITE; PS51330; DHFR_2

Name	Dihydrofolate reductase (DHFR) domain

Function

Dihydrofolate reductases (DHFRs) (EC 1.5.1.3) are ubiquitous enzymes which catalyze the NADPH-linked reduction of 7,8-dihydrofolate to 5,6,7,8- tetrahydrofolate.

+ RecName: EC 1.5.1.3;

Catalytic activity

RHEA:15009: (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH EC 1.5.1.3

PROSITE

PS00075; DHFR_1; 1;

GO:0016491; Molecular function: oxidoreductase activity.
GO:0004146; Molecular function: dihydrofolate reductase activity.
GO:0050661; Molecular function: NADP binding.

NADP
Oxidoreductase

From: PS51330

Key

From

To

Description

Tag

Condition

FTGroup

DOMAIN

from

to

DHFR #

Size range	145-257 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	Q5V3R2 (DYR1_HALMA)
Scope	Bacteria Eukaryota Viruses Archaea
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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• UniProtKB/Swiss-Prot sets
  

  Archaea	[4]
  Bacteria	[51]
  Eukaryota	[37]
  Viruses	[6]
  All	[ 98 ]

  
  
• Retrieve set of proteins with 3D structure for this domain