ProRule PRU00660

General rule information [?]

Accession PRU00660
Dates 21-APR-2009 (Created)
11-JAN-2021 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51330; DHFR_2
Name Dihydrofolate reductase (DHFR) domain
Function Dihydrofolate reductases (DHFRs) (EC are ubiquitous enzymes which catalyze the NADPH-linked reduction of 7,8-dihydrofolate to 5,6,7,8- tetrahydrofolate.
Scope(s) Bacteria
Example(s) Q5V3R2 (DYR1_HALMA);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=;

Comments [?]

CATALYTIC ACTIVITY Reaction=(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH; Xref=Rhea:RHEA:15009, ChEBI:CHEBI:15378, ChEBI:CHEBI:57451, ChEBI:CHEBI:57453, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=;

Keywords [?]

Gene Ontology [?]

GO:0016491; Molecular function:oxidoreductase activity
GO:0004146; Molecular function:dihydrofolate reductase activity
GO:0050661; Molecular function:NADP binding

Cross-references [?]

PROSITE PS00075; DHFR_1; 1;

Features [?]

From: PS51330
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="DHFR #"

Additional information [?]

Size range 145-257 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]