ProRule PRU00660
General rule information
[?]
| Accession | PRU00660 |
| Dates | 21-APR-2009 (Created)
3-SEP-2024 (Last updated, Version 8) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51330; DHFR_2 |
Name | Dihydrofolate reductase (DHFR) domain |
| Function | Dihydrofolate reductases (DHFRs) (EC 1.5.1.3) are ubiquitous enzymes which catalyze the NADPH-linked reduction of 7,8-dihydrofolate to 5,6,7,8- tetrahydrofolate. |
| Scope(s) |
Bacteria Eukaryota Viruses Archaea |
| Example(s) | Q5V3R2 (DYR1_HALMA); |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Protein name | + RecName: EC=1.5.1.3; |
Comments
[?]
| CATALYTIC ACTIVITY | Reaction=(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+); Xref=Rhea:RHEA:15009, ChEBI:CHEBI:15378, ChEBI:CHEBI:57451, ChEBI:CHEBI:57453, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.3; |
Keywords
[?]
Gene Ontology
[?]
| GO:0016491; Molecular function:oxidoreductase activity |
| GO:0004146; Molecular function:dihydrofolate reductase activity |
| GO:0050661; Molecular function:NADP binding |
Cross-references
[?]
| PROSITE | PS00075; DHFR_1; 1; |
Features
[?]
| From: PS51330 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="DHFR #" | |||||||||
Additional information
[?]
| Size range | 145-257 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]