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ProRule PRU00677


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PURL: https://purl.expasy.org/prosite/rule/PRU00677
General rule information [?]

Accession PRU00677
Dates 18-DEC-2007 (Created)
03-JUN-2021 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS51345; MYOTOXINS_2
Name Myotoxins family
Function Myotoxins are small basic peptides (42 to 45 residues) from the venom of rattlesnakes that cause severe muscle necrosis by a non-enzymatic mechanism. Myotoxins contain six cysteines involved in three disulfide bonds.
Scope(s) Eukaryota
Metazoa
Example(s) O73799;

Propagated annotation [?]

Comments [?]

case <Feature:PS00459>
FUNCTIONThis toxin specifically modifies voltage-sensitive sodium channels, it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes.
SUBCELLULAR LOCATIONSecreted.
end case
SIMILARITYBelongs to the snake toxin myotoxin family.

Keywords [?]

Secreted
Ion channel impairing toxin
Potassium channel impairing toxin
Voltage-gated potassium channel impairing toxin
Myotoxin
Toxin
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

case <Feature:PS00459>
GO:0019870; Molecular function:potassium channel inhibitor activity
GO:0008200; Molecular function:ion channel inhibitor activity

Cross-references [?]

PROSITE PS00459; MYOTOXINS_1; 0-1;

Features [?]

From: PS51345
Key From To Description Tag Condition FTGroup
DISULFID 4 36 disulf C-x*-C
DISULFID 11 30 disulf C-x*-C
DISULFID 18 37 disulf C-x*-C

Additional information [?]

Size range 35-50 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]