We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00677
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00677
General rule information
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| Accession | PRU00677 |
| Dates | 18-DEC-2007 (Created)
03-JUN-2021 (Last updated, Version 8) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51345; MYOTOXINS_2 |
Name | Myotoxins family |
| Function | Myotoxins are small basic peptides (42 to 45 residues) from the venom of rattlesnakes that cause severe muscle necrosis by a non-enzymatic mechanism. Myotoxins contain six cysteines involved in three disulfide bonds. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | O73799; |
Propagated annotation
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Comments
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| case <Feature:PS00459> | |
| FUNCTION | This toxin specifically modifies voltage-sensitive sodium channels, it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes. |
| SUBCELLULAR LOCATION | Secreted. |
| end case | |
| SIMILARITY | Belongs to the snake toxin myotoxin family. |
Keywords
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| Secreted | |
| Ion channel impairing toxin | |
| Potassium channel impairing toxin | |
| Voltage-gated potassium channel impairing toxin | |
| Myotoxin | |
| Toxin | |
| end case | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| case <Feature:PS00459> | |
| GO:0019870; Molecular function:potassium channel inhibitor activity | |
| GO:0008200; Molecular function:ion channel inhibitor activity | |
Cross-references
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| PROSITE | PS00459; MYOTOXINS_1; 0-1; |
Features
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| From: PS51345 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DISULFID | 4 | 36 | disulf | C-x*-C | ||||||||
| DISULFID | 11 | 30 | disulf | C-x*-C | ||||||||
| DISULFID | 18 | 37 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 35-50 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [19] All [ 19 ]
- Retrieve set of proteins with 3D structure for this domain