PRU00677
General rule information
[?]
Accession | PRU00677 |
Dates | 18-DEC-2007 (Created) 3-JUN-2021 (Last updated, Version 7) |
Data class | Domain |
Predictors | PROSITE; PS51345; MYOTOXINS_2 |
Name | Myotoxins family |
Function | Myotoxins are small basic peptides (42 to 45 residues) from the venom of rattlesnakes that cause severe muscle necrosis by a non-enzymatic mechanism. Myotoxins contain six cysteines involved in three disulfide bonds. |
Propagated annotation
[?]
Comments
[?]
case <Feature:PS00459>
Function | This toxin specifically modifies voltage-sensitive sodium channels, it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes. |
Subcellular location | Secreted. |
end case
Similarity | Belongs to the snake toxin myotoxin family. |
Cross-references
[?]
PROSITE | PS00459; MYOTOXINS_1; 0-1; |
Gene Ontology
[?]
case <Feature:PS00459>
GO:0019870; Molecular function: potassium channel inhibitor activity.
GO:0008200; Molecular function: ion channel inhibitor activity.
GO:0008200; Molecular function: ion channel inhibitor activity.
Keywords
[?]
Secreted
Ion channel impairing toxin
Potassium channel impairing toxin
Voltage-gated potassium channel impairing toxin
Myotoxin
Toxin
Ion channel impairing toxin
Potassium channel impairing toxin
Voltage-gated potassium channel impairing toxin
Myotoxin
Toxin
end case
case <FTTag:disulf>
end case
Features
[?]
From: PS51345 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DISULFID | 4 | 36 | disulf | C-x*-C | ||||||||
DISULFID | 11 | 30 | disulf | C-x*-C | ||||||||
DISULFID | 18 | 37 | disulf | C-x*-C |
Additional information
[?]
Size range | 35-50 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | O73799 (MYC3_CRODU) |
Scope | Eukaryota; Metazoa; Squamata; Serpentes |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]
-
UniProtKB/Swiss-Prot sets
Eukaryota [19]
- Retrieve set of proteins with 3D structure for this domain