ProRule PRU00677
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00677 |
| Accession | PRU00677 |
| Dates | 18-DEC-2007 (Created)
3-JUN-2021 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51345; MYOTOXINS_2 |
Name | Myotoxins family |
| Function | Myotoxins are small basic peptides (42 to 45 residues) from the venom of rattlesnakes that cause severe muscle necrosis by a non-enzymatic mechanism. Myotoxins contain six cysteines involved in three disulfide bonds. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | O73799 (MYC3_CRODU); |
Propagated annotation
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Comments
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| case <Feature:PS00459> | |
| FUNCTION | This toxin specifically modifies voltage-sensitive sodium channels, it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes. |
| SUBCELLULAR LOCATION | Secreted. |
| end case | |
| SIMILARITY | Belongs to the snake toxin myotoxin family. |
Keywords
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| Secreted | |
| Ion channel impairing toxin | |
| Potassium channel impairing toxin | |
| Voltage-gated potassium channel impairing toxin | |
| Myotoxin | |
| Toxin | |
| end case | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| case <Feature:PS00459> | |
| GO:0019870; Molecular function:potassium channel inhibitor activity | |
| GO:0008200; Molecular function:ion channel inhibitor activity | |
Cross-references
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| PROSITE | PS00459; MYOTOXINS_1; 0-1; |
Features
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| From: PS51345 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DISULFID | 4 | 36 | disulf | C-x*-C | ||||||||
| DISULFID | 11 | 30 | disulf | C-x*-C | ||||||||
| DISULFID | 18 | 37 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 35-50 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [19] All [ 19 ]
- Retrieve set of proteins with 3D structure for this domain