PRU00677

General rule information [?]

Accession	PRU00677
Dates	18-DEC-2007 (Created) 3-JUN-2021 (Last updated, Version 7)

Data class

Domain

Predictors

PROSITE; PS51345; MYOTOXINS_2

Name	Myotoxins family

Function

Myotoxins are small basic peptides (42 to 45 residues) from the venom of rattlesnakes that cause severe muscle necrosis by a non-enzymatic mechanism. Myotoxins contain six cysteines involved in three disulfide bonds.

Propagated annotation [?]

Comments [?]

case <Feature:PS00459>

Function	This toxin specifically modifies voltage-sensitive sodium channels, it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes.
Subcellular location	Secreted.

end case

Similarity

Belongs to the snake toxin myotoxin family.

Cross-references [?]

PROSITE

PS00459; MYOTOXINS_1; 0-1;

Gene Ontology [?]

case <Feature:PS00459>

GO:0019870; Molecular function: potassium channel inhibitor activity.
GO:0008200; Molecular function: ion channel inhibitor activity.

Keywords [?]

Secreted
Ion channel impairing toxin
Potassium channel impairing toxin
Voltage-gated potassium channel impairing toxin
Myotoxin
Toxin

end case

case <FTTag:disulf>

Disulfide bond

end case

Features [?]

From: PS51345

Key From To Description Tag Condition FTGroup

DISULFID 4 36 disulf C-x*-C

DISULFID 11 30 disulf C-x*-C

DISULFID 18 37 disulf C-x*-C

Additional information [?]

Size range	35-50 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	O73799 (MYC3_CRODU)
Scope	Eukaryota; Metazoa; Squamata; Serpentes

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Eukaryota [19]
Retrieve set of proteins with 3D structure for this domain