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annotation rule: PRU00677

General rule information [?]

Accession PRU00677
Dates 18-DEC-2007 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51345; MYOTOXINS_2
Name Myotoxins family
Function Myotoxins are small basic peptides (42 to 45 residues) from the venom of rattlesnakes that cause severe muscle necrosis by a non-enzymatic mechanism. Myotoxins contain six cysteines involved in three disulfide bonds.

Propagated annotation [?]


Comments [?]

case <Feature:PS00459>
Function This toxin specifically modifies voltage-sensitive sodium channels, it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes.
Subcellular location Secreted.
end case

Similarity Belongs to the snake toxin myotoxin family.

Cross-references [?]

PROSITE PS00459; MYOTOXINS_1; 0-1;

Gene Ontology [?]

case <Feature:PS00459>
GO:0019870; Molecular function: potassium channel inhibitor activity.
GO:0008200; Molecular function: ion channel inhibitor activity.
GO:0009405; Biological process: pathogenesis.

Keywords [?]

end case

case <FTTag:disulf>
end case


Features [?]

From: PS51345
Key     From     To       Description   Tag   Condition   FTGroup
DISULFID     4     36           disulf   C-x*-C  
DISULFID     11     30           disulf   C-x*-C  
DISULFID     18     37           disulf   C-x*-C  

Additional information [?]

Size range 35-50 amino acids
Related rules None
Repeats 1
Topology Undefined
Example O73799 (MYC3_CRODU)
Scope
Eukaryota; Metazoa; Squamata; Serpentes

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]