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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00679


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00679
General rule information [?]

Accession PRU00679
Dates 18-DEC-2007 (Created)
19-NOV-2022 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS51347; PHOSPHOTRIESTERASE_2
Name Phosphotriesterase family
Function The enzyme phosphotriesterase (EC 3.1.8.1) (PTE) (also known as parathion hydrolase) belongs to a family of enzymes that possess a binuclear zinc metal center at their active site. The two zinc ions are coordinated by six different residues, four of which being histidines.
Scope(s) Eukaryota
Bacteria
Example(s) P0A433;

Propagated annotation [?]

Comments [?]

case <FTGroup:1> and <FTGroup:2>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
end case
SIMILARITYBelongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.

Keywords [?]

Hydrolase
Metal-binding
Zinc
end case

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>
GO:0016787; Molecular function:hydrolase activity
GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding

Cross-references [?]

PROSITE PS01322; PHOSPHOTRIESTERASE_1; 1;

Features [?]

From: PS51347
Key From To Description Tag Condition FTGroup
BINDING 21 21 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 H 1
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 H 1
BINDING 142 142 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/note="via carbamate group"		 [KE] 1
BINDING 142 142 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"
/note="via carbamate group"		 [KE] 2
BINDING 175 175 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 H 2
BINDING 204 204 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 H 2
BINDING 263 263 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 D 1
MOD_RES 142 142 /note="N6-carboxylysine" K

Additional information [?]

Size range 280-360 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]