PRU00679

General rule information [?]

Accession	PRU00679
Dates	18-DEC-2007 (Created) 19-NOV-2022 (Last updated, Version 9)

Data class

Domain

Predictors

PROSITE; PS51347; PHOSPHOTRIESTERASE_2

Name	Phosphotriesterase family

Function

The enzyme phosphotriesterase (EC 3.1.8.1) (PTE) (also known as parathion hydrolase) belongs to a family of enzymes that possess a binuclear zinc metal center at their active site. The two zinc ions are coordinated by six different residues, four of which being histidines.

Propagated annotation [?]

Comments [?]

case <FTGroup:1> and <FTGroup:2>

Cofactor

Zn(2+)
Note: Binds 2 Zn(2+) ions per subunit.

end case

Similarity

Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.

Cross-references [?]

case <FTGroup:1>

PROSITE

PS01322; PHOSPHOTRIESTERASE_1; 1;

end case

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>

GO:0016787; Molecular function: hydrolase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

Hydrolase
Metal-binding
Zinc

end case

Features [?]

From: PS51347

Key From To Description Tag Condition FTGroup

BINDING 21 21 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 H 1

BINDING 23 23 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 H 1

BINDING 142 142 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /note="via carbamate group [KE] 1

BINDING 142 142 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /note="via carbamate group [KE] 2

BINDING 175 175 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 H 2

BINDING 204 204 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2 H 2

BINDING 263 263 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1 D 1

MOD_RES 142 142 N6-carboxylysine K

Additional information [?]

Size range	280-360 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	P0A433 (OPD_SPHSA)
Scope	Eukaryota Bacteria

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Archaea [1]

Bacteria [8]

Eukaryota [24]

All [ 33 ]
Retrieve set of proteins with 3D structure for this domain

Archaea	[1]
Bacteria	[8]
Eukaryota	[24]
All	[ 33 ]