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annotation rule: PRU00679

General rule information [?]

Accession PRU00679
Dates 18-DEC-2007 (Created)
21-NOV-2019 (Last updated, Version 7)
Data class Domain
Predictors PROSITE; PS51347; PHOSPHOTRIESTERASE_2
Name Phosphotriesterase family
Function The enzyme phosphotriesterase (EC 3.1.8.1) (PTE) (also known as parathion hydrolase) belongs to a family of enzymes that possess a binuclear zinc metal center at their active site. The two zinc ions are coordinated by six different residues, four of which being histidines.

Propagated annotation [?]


Comments [?]

case <FTGroup:1> and <FTGroup:2>
Cofactor Zn(2+)
Note: Binds 2 Zn(2+) ions per subunit.
end case

Similarity Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.

Cross-references [?]

case <FTGroup:1>
PROSITE PS01322; PHOSPHOTRIESTERASE_1; 1;
end case


Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>
GO:0016787; Molecular function: hydrolase activity.
GO:0046872; Molecular function: metal ion binding.
GO:0008270; Molecular function: zinc ion binding.

Keywords [?]

Hydrolase
Metal-binding
Zinc
end case


Features [?]

From: PS51347
Key     From     To       Description   Tag   Condition   FTGroup
METAL     21     21       Zinc #1     H   1
METAL     23     23       Zinc #1     H   1
METAL     142     142       Zinc #1; via carbamate group     [KE]   1
METAL     142     142       Zinc #2; via carbamate group     [KE]   2
METAL     175     175       Zinc #2     H   2
METAL     204     204       Zinc #2     H   2
METAL     263     263       Zinc #1     D   1
MOD_RES     142     142       N6-carboxylysine     K  

Additional information [?]

Size range 280-360 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0A433 (OPD_SPHSA)
Scope
Eukaryota
Bacteria

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Archaea [1]
Bacteria [8]
Eukaryota [24]
All [ 33 ]