ProRule PRU00679
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00679 |
| Accession | PRU00679 |
| Dates | 18-DEC-2007 (Created)
19-NOV-2022 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51347; PHOSPHOTRIESTERASE_2 |
Name | Phosphotriesterase family |
| Function | The enzyme phosphotriesterase (EC 3.1.8.1) (PTE) (also known as parathion hydrolase) belongs to a family of enzymes that possess a binuclear zinc metal center at their active site. The two zinc ions are coordinated by six different residues, four of which being histidines. |
| Scope(s) |
Eukaryota Bacteria |
| Example(s) | P0A433 (OPD_SPHSA); |
Propagated annotation
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Comments
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| case <FTGroup:1> and <FTGroup:2> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.; |
| end case | |
| SIMILARITY | Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family. |
Keywords
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| Hydrolase | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| case <FTGroup:1> or <FTGroup:2> | |
| GO:0016787; Molecular function:hydrolase activity | |
| GO:0046872; Molecular function:metal ion binding | |
| GO:0008270; Molecular function:zinc ion binding | |
Cross-references
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| PROSITE | PS01322; PHOSPHOTRIESTERASE_1; 1; |
Features
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| From: PS51347 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 21 | 21 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
H | 1 | |||||||
| BINDING | 23 | 23 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
H | 1 | |||||||
| BINDING | 142 | 142 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" /note="via carbamate group" |
[KE] | 1 | |||||||
| BINDING | 142 | 142 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" /note="via carbamate group" |
[KE] | 2 | |||||||
| BINDING | 175 | 175 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" |
H | 2 | |||||||
| BINDING | 204 | 204 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" |
H | 2 | |||||||
| BINDING | 263 | 263 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
D | 1 | |||||||
| MOD_RES | 142 | 142 | /note="N6-carboxylysine" | K | ||||||||
Additional information
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| Size range | 280-360 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [1] Bacteria [8] Eukaryota [24] All [ 33 ]
- Retrieve set of proteins with 3D structure for this domain