 |
|
| annotation rule: PRU00680 |
General rule information
[?]
| Accession | PRU00680 |
| Dates | 18-DEC-2007 (Created) 31-MAY-2018 (Last updated, Version 5) |
| Data class | Domain |
| Predictors | PROSITE; PS51348; LACTALBUMIN_LYSOZYME_2 |
| Name | Alpha-lactalbumin / lysozyme C family |
| Function | Alpha-lactalbumin, a regulatory protein in milk, and lysozyme (EC 3.2.1.17) C (chicken type), which acts as a bacteriolytic enzyme, belong to a family of proteins with eight conserved cysteines that form four disulfide bonds. Alpha-lactalbumin lacks the enzymatic activity and the corresponding Glu and Asp residues. Alpha-lactalbumin binds a calcium ion, while most lysozyme C do not bind calcium. |
Propagated annotation
[?]
Description
[?]
case <FTGroup:1>
| + AltName: Full=lysozyme C; EC=3.2.1.17; AltName: Full=1,4-beta-N-acetylmuramidase C; |
Comments
[?]
| Function | Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. |
| Catalytic activity | Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. |
end case
| Similarity | Belongs to the glycosyl hydrolase 22 family. |
Cross-references
[?]
| PROSITE | PS00128; LACTALBUMIN_LYSOZYME_1; 1; |
Gene Ontology
[?]
case <FTGroup:1>
GO:0003824; Molecular function: catalytic activity.
GO:0019835; Biological process: cytolysis.
GO:0042742; Biological process: defense response to bacterium.
GO:0016798; Molecular function: hydrolase activity, acting on glycosyl bonds.
GO:0008152; Biological process: metabolic process.
GO:0016787; Molecular function: hydrolase activity.
GO:0019835; Biological process: cytolysis.
GO:0042742; Biological process: defense response to bacterium.
GO:0016798; Molecular function: hydrolase activity, acting on glycosyl bonds.
GO:0008152; Biological process: metabolic process.
GO:0016787; Molecular function: hydrolase activity.
end case
case <Feature:PS51348:85=D> and <Feature:PS51348:90-91=D-D>
GO:0005509; Molecular function: calcium ion binding.
end case
Keywords
[?]
case <FTGroup:1>
end case
case <Feature:PS51348:85=D> and <Feature:PS51348:90-91=D-D>
end case
case <FTTag:disulf>
end case
Features
[?]
| From: PS51348 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 35 | 35 | E | 1 | ||||||||
| ACT_SITE | 52 | 52 | D | 1 | ||||||||
case <Feature:PS51348:85=D> and <Feature:PS51348:90-91=D-D>
end case
| DISULFID | 6 | 125 | disulf | C-x*-C | ||||||||
| DISULFID | 30 | 114 | disulf | C-x*-C | ||||||||
| DISULFID | 64 | 80 | disulf | C-x*-C | ||||||||
| DISULFID | 76 | 94 | disulf | C-x*-C |
Additional information
[?]
| Size range | 110-140 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q659U0 (LYSC_LEPWE) |
| Scope | Eukaryota; Metazoa |
PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.
UniProtKB rule member sequences
[?]
-
UniProtKB/Swiss-Prot sets
Eukaryota [153]
- Retrieve set of proteins with 3D structure for this domain