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| annotation rule: PRU00680 |
General rule information
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| Accession | PRU00680 |
| Dates | 18-DEC-2007 (Created) 21-NOV-2019 (Last updated, Version 9) |
| Data class | Domain |
| Predictors | PROSITE; PS51348; GLYCOSYL_HYDROL_F22_2 |
| Name | Glycosyl hydrolases family 22 (GH22) domain |
| Function | Alpha-lactalbumin, a regulatory protein in milk, and lysozyme (EC 3.2.1.17) C (chicken type), which acts as a bacteriolytic enzyme, belong to a family of proteins with eight conserved cysteines that form four disulfide bonds. Alpha-lactalbumin lacks the enzymatic activity and the corresponding Glu and Asp residues. Alpha-lactalbumin binds a calcium ion, while most lysozyme C do not bind calcium. |
Propagated annotation
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Description
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case <FTGroup:1>
| + AltName: Full=lysozyme C; EC 3.2.1.17; AltName: Full=1,4-beta-N-acetylmuramidase C; |
Comments
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| Function | Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. |
| Catalytic activity | Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17; |
end case
| Similarity | Belongs to the glycosyl hydrolase 22 family. |
Cross-references
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| PROSITE | PS00128; GLYCOSYL_HYDROL_F22_1; 1; |
Gene Ontology
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case <FTGroup:1>
GO:0003824; Molecular function: catalytic activity.
GO:0019835; Biological process: cytolysis.
GO:0042742; Biological process: defense response to bacterium.
GO:0016798; Molecular function: hydrolase activity, acting on glycosyl bonds.
GO:0008152; Biological process: metabolic process.
GO:0016787; Molecular function: hydrolase activity.
GO:0019835; Biological process: cytolysis.
GO:0042742; Biological process: defense response to bacterium.
GO:0016798; Molecular function: hydrolase activity, acting on glycosyl bonds.
GO:0008152; Biological process: metabolic process.
GO:0016787; Molecular function: hydrolase activity.
end case
case <Feature:PS51348:85=D> and <Feature:PS51348:90-91=D-D>
GO:0005509; Molecular function: calcium ion binding.
end case
Keywords
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case <FTGroup:1>
end case
case <Feature:PS51348:85=D> and <Feature:PS51348:90-91=D-D>
end case
case <FTTag:disulf>
end case
Features
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| From: PS51348 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | C-type lysozyme # | |||||||||
| ACT_SITE | 35 | 35 | E | 1 | ||||||||
| ACT_SITE | 52 | 52 | D | 1 | ||||||||
case <Feature:PS51348:85=D> and <Feature:PS51348:90-91=D-D>
end case
| DISULFID | 6 | 125 | disulf | C-x*-C | ||||||||
| DISULFID | 30 | 114 | disulf | C-x*-C | ||||||||
| DISULFID | 64 | 80 | disulf | C-x*-C | ||||||||
| DISULFID | 76 | 94 | disulf | C-x*-C |
Additional information
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| Size range | 110-140 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q659U0 (LYSC_LEPWE) |
| Scope | Eukaryota; Metazoa |
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UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Eukaryota [157]
- Retrieve set of proteins with 3D structure for this domain