ProRule PRU00706

General rule information [?]

Accession	PRU00706
Dates	20-DEC-2023 (Created) -- (Last updated, Version 1)
Data class	Domain;
Predictors	PROSITE; PS51374; NDPK_LIKE
Name	Nucleoside diphosphate kinase (NDK)-like domain
Function	All Nme enzymes possess at least one nucleoside diphosphate kinase (NDK)-like domain of ~150 amino acids.
Scope(s)	Bacteria Eukaryota Archaea Viruses Mimivirus bradfordmassiliense
Example(s)	C3LT09 (NDK_VIBCM);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1> and <FTTag:act_site>
Protein name	+ AltName: Full=Nucleoside diphosphate kinase; Short=NDK; Short=NDP kinase {ECO:0000255\|HAMAP-Rule:MF_00451}; EC=2.7.4.6;
end case

Comments [?]

case <FTGroup:1> and <FTTag:act_site>
CATALYTIC ACTIVITY	Reaction=a 2'-deoxyribonucleoside 5'- diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6;
CATALYTIC ACTIVITY	Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6;
COFACTOR	Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
SIMILARITY	Belongs to the NDK family.

Keywords [?]

Gene Ontology [?]

GO:0004550; Molecular function:nucleoside diphosphate kinase activity

GO:0006241; Biological process:CTP biosynthetic process

GO:0005524; Molecular function:ATP binding

GO:0006228; Biological process:UTP biosynthetic process

GO:0006183; Biological process:GTP biosynthetic process

GO:0016310; Biological process:phosphorylation

GO:0046872; Molecular function:metal ion binding

Cross-references [?]

PROSITE

PS00469; NDPK; 1;

Features [?]

From: PS51374

Key

From

Description

Tag

Condition

FTGroup

DOMAIN

from

/note="NDPK-like #"

case <FTGroup:1>

ACT_SITE

114

/note="Pros-phosphohistidine intermediate"

act_site

end case

BINDING