ProRule PRU00706

General rule information [?]

Accession PRU00706
Dates 20-DEC-2023 (Created)
-- (Last updated, Version 1)
Data class Domain;
Predictors PROSITE; PS51374; NDPK_LIKE
Name Nucleoside diphosphate kinase (NDK)-like domain
Function All Nme enzymes possess at least one nucleoside diphosphate kinase (NDK)-like domain of ~150 amino acids.
Scope(s) Bacteria
Mimivirus bradfordmassiliense
Example(s) C3LT09 (NDK_VIBCM);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1> and <FTTag:act_site>
Protein name + AltName: Full=Nucleoside diphosphate kinase;
                 Short=NDP kinase {ECO:0000255|HAMAP-Rule:MF_00451};
end case

Comments [?]

case <FTGroup:1> and <FTTag:act_site>
CATALYTIC ACTIVITYReaction=a 2'-deoxyribonucleoside 5'- diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=;
CATALYTIC ACTIVITYReaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=;
COFACTORName=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
SIMILARITYBelongs to the NDK family.

Keywords [?]

Gene Ontology [?]

GO:0004550; Molecular function:nucleoside diphosphate kinase activity
GO:0006241; Biological process:CTP biosynthetic process
GO:0005524; Molecular function:ATP binding
GO:0006228; Biological process:UTP biosynthetic process
GO:0006183; Biological process:GTP biosynthetic process
GO:0016310; Biological process:phosphorylation
GO:0046872; Molecular function:metal ion binding

Cross-references [?]


Features [?]

From: PS51374
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="NDPK-like #"
case <FTGroup:1>
ACT_SITE 114 114 /note="Pros-phosphohistidine intermediate" act_site H
end case
BINDING 8 8 /ligand="ATP"
K 1
BINDING 56 56 /ligand="ATP"
F 1
BINDING 84 84 /ligand="ATP"
R 1
BINDING 90 90 /ligand="ATP"
T 1
BINDING 101 101 /ligand="ATP"
R 1
BINDING 111 111 /ligand="ATP"
N 1

Additional information [?]

Size range 21-180 amino acids
Related rules None
Fusion None
Repeats 1-3
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB rule member sequences [?]