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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00720


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00720
General rule information [?]

Accession PRU00720
Dates 31-JUL-2008 (Created)
21-NOV-2019 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51388; GED
Name GED domain
Function Dynamin superfamily members are large GTPases, conserved through evolution mainly described as mechanochemical enzymes involved in membrane scission events. All members display a common architecture: a large GTPase domain followed by a 'middle domain' of ill-defined function and a downstream coiled-coil GTPase effector domain (GED) that functions in higher order assembly and as a GTPase activating protein (GAP) for dynamin's GTPase activity.
Scope(s) Eukaryota
Example(s) Q05193;

Propagated annotation [?]

Features [?]

From: PS51388
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="GED #"

Additional information [?]

Size range 70-100 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]