PROSITE logo

ProRule PRU00726


General rule information [?]

Accession PRU00726
Dates 11-JUL-2008 (Created)
19-NOV-2022 (Last updated, Version 12)
Data class Domain;
Predictors PROSITE; PS51393; LIPOXYGENASE_3
Name Lipoxygenase iron-binding catalytic domain
Function Lipoxygenases (EC 1.13.11.-) form a class of iron-containing fatty acid dioxygenases, which catalyze the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure.
Scope(s) Eukaryota
Bacteria
Example(s) Q84YK8 (); Q9BYJ1 (); Q8RNT4 (LOX_PSEAI);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Viridiplantae>
Protein name AltName: Full=lipoxygenase;
                 EC=1.13.11.-;

Comments [?]

FUNCTIONPlant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure.
end case

Keywords [?]


Gene Ontology [?]

GO:0016702; Molecular function:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
case <FTGroup:1>
GO:0005506; Molecular function:iron ion binding
GO:0046872; Molecular function:metal ion binding
end case
GO:0016491; Molecular function:oxidoreductase activity
case <OCellular component:Viridiplantae>
GO:0006633; Biological process:fatty acid biosynthetic process
GO:0008610; Biological process:lipid biosynthetic process
GO:0031408; Biological process:oxylipin biosynthetic process
end case
case <OCellular component:Bacteria>
GO:0042597; Cellular component:periplasmic space
end case

Cross-references [?]

PROSITE PS00711; LIPOXYGENASE_1; 1;
PROSITE PS00081; LIPOXYGENASE_2; 1;

Features [?]

From: PS51393
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Lipoxygenase #"
BINDING 340 340 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
/ligand_note="catalytic"
H 1
BINDING 345 345 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
/ligand_note="catalytic"
H 1
BINDING 530 530 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
/ligand_note="catalytic"
H 1
BINDING 534 534 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
/ligand_note="catalytic"
[NH] 1
BINDING 678 678 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
/ligand_note="catalytic"
I 1

Additional information [?]

Size range 540-730 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



View rule in raw text format (no links)

UniProtKB rule member sequences [?]