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annotation rule: PRU00726

General rule information [?]

Accession PRU00726
Dates 11-JUL-2008 (Created)
21-NOV-2019 (Last updated, Version 10)
Data class Domain
Predictors PROSITE; PS51393; LIPOXYGENASE_3
Name Lipoxygenase iron-binding catalytic domain
Function Lipoxygenases (EC 1.13.11.-) form a class of iron-containing fatty acid dioxygenases, which catalyze the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure.

Propagated annotation [?]


Description [?]

case <OC:Viridiplantae>
AltName: Full=lipoxygenase; EC 1.13.11.-;

Comments [?]

Function Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure.
end case

case <FTGroup:1>
Cofactor Fe cation
Note: Binds 1 Fe cation per subunit.
end case

case <OC:Viridiplantae>
Pathway Lipid metabolism; oxylipin biosynthesis.
end case

case <OC:Metazoa>
Subcellular location Cytoplasm.
end case

case <OC:Bacteria>
Subcellular location Periplasm.
end case


Cross-references [?]

case <Feature:PS51393:340=H> and <Feature:PS51393:345=H>
PROSITE PS00711; LIPOXYGENASE_1; 1;
end case

case <Feature:PS51393:530=H>
PROSITE PS00081; LIPOXYGENASE_2; 1;
end case


Gene Ontology [?]

GO:0016702; Molecular function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen.
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
GO:0046872; Molecular function: metal ion binding.
end case

GO:0016491; Molecular function: oxidoreductase activity.
case <OC:Viridiplantae>
GO:0006633; Biological process: fatty acid biosynthetic process.
GO:0008610; Biological process: lipid biosynthetic process.
GO:0031408; Biological process: oxylipin biosynthetic process.
end case

case <OC:Bacteria>
GO:0042597; Cellular component: periplasmic space.
end case


Keywords [?]

Dioxygenase
case <FTGroup:1>
Iron
Metal-binding
end case

Oxidoreductase
case <OC:Viridiplantae>
Lipid metabolism
Lipid biosynthesis
Fatty acid biosynthesis
Fatty acid metabolism
Oxylipin biosynthesis
end case

case <OC:Bacteria>
Periplasm
end case


Features [?]

From: PS51393
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Lipoxygenase #        
METAL     340     340       Iron; catalytic     H   1
METAL     345     345       Iron; catalytic     H   1
METAL     530     530       Iron; catalytic     H   1
METAL     534     534       Iron; catalytic     [NH]   1
METAL     678     678       Iron; via carboxylate; catalytic     I   1

Additional information [?]

Size range 540-730 amino acids
Related rules None
Repeats 1
Topology Undefined
Examples Q84YK8 (LOXC2_ORYSJ); Q9BYJ1 (LOXE3_HUMAN); Q8RNT4 (LOX_PSEAI): [Recover all]
Scope
Eukaryota
Bacteria

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]