General rule information
[?]
Accession |
PRU00726 |
Dates |
11-JUL-2008 (Created) 21-NOV-2019 (Last updated, Version 10) |
Predictors |
PROSITE; PS51393; LIPOXYGENASE_3
|
Name |
Lipoxygenase iron-binding catalytic domain |
Function |
Lipoxygenases (EC 1.13.11.-) form a class of iron-containing fatty acid dioxygenases, which catalyze the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure. |
Propagated annotation
[?]
case <OC:Viridiplantae>
Function |
Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure. |
end case
case <FTGroup:1>
Cofactor |
Fe cation Note: Binds 1 Fe cation per subunit. |
end case
case <OC:Viridiplantae>
Pathway |
Lipid metabolism; oxylipin biosynthesis. |
end case
case <OC:Metazoa>
Subcellular location |
Cytoplasm. |
end case
case <OC:Bacteria>
Subcellular location |
Periplasm. |
end case
case <Feature:PS51393:340=H> and <Feature:PS51393:345=H>
PROSITE |
PS00711; LIPOXYGENASE_1; 1; |
end case
case <Feature:PS51393:530=H>
PROSITE |
PS00081; LIPOXYGENASE_2; 1; |
end case
GO:0016702; Molecular function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen.
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
GO:0046872; Molecular function: metal ion binding.
end case
GO:0016491; Molecular function: oxidoreductase activity.
case <OC:Viridiplantae>
GO:0006633; Biological process: fatty acid biosynthetic process.
GO:0008610; Biological process: lipid biosynthetic process.
GO:0031408; Biological process: oxylipin biosynthetic process.
end case
case <OC:Bacteria>
GO:0042597; Cellular component: periplasmic space.
end case
case <FTGroup:1>
end case
case <OC:Viridiplantae>
end case
case <OC:Bacteria>
end case
From: PS51393 |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
|
DOMAIN
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from
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to
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Lipoxygenase #
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METAL
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340
|
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340
|
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Iron; catalytic
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H
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1
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METAL
|
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345
|
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345
|
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Iron; catalytic
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|
|
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H
|
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1
|
METAL
|
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530
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530
|
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Iron; catalytic
|
|
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|
H
|
|
1
|
METAL
|
|
534
|
|
534
|
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Iron; catalytic
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|
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[NH]
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1
|
METAL
|
|
678
|
|
678
|
|
Iron; via carboxylate; catalytic
|
|
|
|
I
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|
1
|
Additional information
[?]
Size range |
540-730 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Examples |
Q84YK8 (LOXC2_ORYSJ); Q9BYJ1 (LOXE3_HUMAN); Q8RNT4 (LOX_PSEAI): [Recover all] |
Scope |
Eukaryota
Bacteria |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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