PRU00726
General rule information
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Accession | PRU00726 |
Dates | 11-JUL-2008 (Created) 19-NOV-2022 (Last updated, Version 12) |
Data class | Domain |
Predictors | PROSITE; PS51393; LIPOXYGENASE_3 |
Name | Lipoxygenase iron-binding catalytic domain |
Function | Lipoxygenases (EC 1.13.11.-) form a class of iron-containing fatty acid dioxygenases, which catalyze the hydroperoxidation of lipids, containing a cis,cis-1,4-pentadiene structure. |
Propagated annotation
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Description
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case <OC:Viridiplantae>
AltName: Full=lipoxygenase; EC 1.13.11.-; |
Comments
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Function | Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure. |
end case
case <FTGroup:1>
Cofactor | Fe cation Note: Binds 1 Fe cation per subunit. |
end case
case <OC:Viridiplantae>
Pathway | Lipid metabolism; oxylipin biosynthesis. |
end case
case <OC:Metazoa>
Subcellular location | Cytoplasm. |
end case
case <OC:Bacteria>
Subcellular location | Periplasm. |
end case
Cross-references
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case <Feature:PS51393:340=H> and <Feature:PS51393:345=H>
PROSITE | PS00711; LIPOXYGENASE_1; 1; |
end case
case <Feature:PS51393:530=H>
PROSITE | PS00081; LIPOXYGENASE_2; 1; |
end case
Gene Ontology
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GO:0016702; Molecular function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen.
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
GO:0046872; Molecular function: metal ion binding.
GO:0046872; Molecular function: metal ion binding.
end case
GO:0016491; Molecular function: oxidoreductase activity.
case <OC:Viridiplantae>
GO:0006633; Biological process: fatty acid biosynthetic process.
GO:0008610; Biological process: lipid biosynthetic process.
GO:0031408; Biological process: oxylipin biosynthetic process.
GO:0008610; Biological process: lipid biosynthetic process.
GO:0031408; Biological process: oxylipin biosynthetic process.
end case
case <OC:Bacteria>
GO:0042597; Cellular component: periplasmic space.
end case
Keywords
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case <FTGroup:1>
end case
case <OC:Viridiplantae>
Lipid metabolism
Lipid biosynthesis
Fatty acid biosynthesis
Fatty acid metabolism
Oxylipin biosynthesis
Lipid biosynthesis
Fatty acid biosynthesis
Fatty acid metabolism
Oxylipin biosynthesis
end case
case <OC:Bacteria>
end case
Features
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From: PS51393 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | Lipoxygenase # | |||||||||
BINDING | 340 | 340 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 345 | 345 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 530 | 530 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 534 | 534 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_note="catalytic | [NH] | 1 | |||||||
BINDING | 678 | 678 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" /ligand_note="catalytic | I | 1 |
Additional information
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Size range | 540-730 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Examples | Q84YK8 (LOXC2_ORYSJ); Q9BYJ1 (LOXE3_HUMAN); Q8RNT4 (LOX_PSEAI): [Recover all] |
Scope | Eukaryota
Bacteria |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Bacteria [3] Eukaryota [76] All [ 79 ]
- Retrieve set of proteins with 3D structure for this domain