Home  |  Contact
annotation rule: PRU00736

General rule information [?]

Accession PRU00736
Dates 10-DEC-2008 (Created)
21-NOV-2019 (Last updated, Version 10)
Data class Domain
Predictors PROSITE; PS51403; NC1_IV
Name Collagen IV carboxyl-terminal non-collagenous (NC1) domain
Function Each type IV chain contains a long triple-helical collagenous domain flanked by a short 7S domain of 25 residues and a globular non-collagenous NC1 domain of ~230 residues at the N- and C-terminus, respectively.

Propagated annotation [?]

Comments [?]

Subcellular location Secreted, extracellular space, extracellular matrix, basement membrane.
Domain Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.
Ptm Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
Similarity Belongs to the type IV collagen family.

Gene Ontology [?]

GO:0005604; Cellular component: basement membrane.
GO:0031012; Cellular component: extracellular matrix.

Keywords [?]

case <FTTag:disulf>
end case

Features [?]

From: PS51403
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Collagen IV NC1 #        
DISULFID     16     106           disulf   C-x*-C  
DISULFID     49     103           disulf   C-x*-C  
DISULFID     61     67           disulf   C-x*-C  
DISULFID     125     220           disulf   C-x*-C  
DISULFID     159     217           disulf   C-x*-C  
DISULFID     171     177           disulf   C-x*-C  

Additional information [?]

Size range 220-230 amino acids
Related rules None
Repeats 1
Topology Not cytoplasmic
Example P02462 (CO4A1_HUMAN)
Eukaryota; Metazoa
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]