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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00736


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PURL: https://purl.expasy.org/prosite/rule/PRU00736
General rule information [?]

Accession PRU00736
Dates 10-DEC-2008 (Created)
21-NOV-2019 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS51403; NC1_IV
Name Collagen IV carboxyl-terminal non-collagenous (NC1) domain
Function Each type IV chain contains a long triple-helical collagenous domain flanked by a short 7S domain of 25 residues and a globular non-collagenous NC1 domain of ~230 residues at the N- and C-terminus, respectively.
Scope(s) Eukaryota
Metazoa
Example(s) P02462;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONSecreted, extracellular space, extracellular matrix, basement membrane.
DOMAINAlpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.
PTMProlines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
PTMType IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
SIMILARITYBelongs to the type IV collagen family.

Keywords [?]

Basement membrane
Collagen
Extracellular matrix
Secreted
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

GO:0005604; Cellular component:basement membrane
GO:0031012; Cellular component:extracellular matrix

Features [?]

From: PS51403
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Collagen IV NC1 #"
DISULFID 16 106 disulf C-x*-C
DISULFID 49 103 disulf C-x*-C
DISULFID 61 67 disulf C-x*-C
DISULFID 125 220 disulf C-x*-C
DISULFID 159 217 disulf C-x*-C
DISULFID 171 177 disulf C-x*-C

Additional information [?]

Size range 220-230 amino acids
Related rules None
Fusion None
Repeats 1
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]