ProRule PRU00736

General rule information [?]

Accession PRU00736
Dates 10-DEC-2008 (Created)
21-NOV-2019 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS51403; NC1_IV
Name Collagen IV carboxyl-terminal non-collagenous (NC1) domain
Function Each type IV chain contains a long triple-helical collagenous domain flanked by a short 7S domain of 25 residues and a globular non-collagenous NC1 domain of ~230 residues at the N- and C-terminus, respectively.
Scope(s) Eukaryota
Example(s) P02462 (CO4A1_HUMAN);

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONSecreted, extracellular space, extracellular matrix, basement membrane.
DOMAINAlpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.
PTMProlines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
PTMType IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
SIMILARITYBelongs to the type IV collagen family.

Keywords [?]

Gene Ontology [?]

GO:0005604; Cellular component:basement membrane
GO:0031012; Cellular component:extracellular matrix

Features [?]

From: PS51403
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Collagen IV NC1 #"
DISULFID 16 106 disulf C-x*-C
DISULFID 49 103 disulf C-x*-C
DISULFID 61 67 disulf C-x*-C
DISULFID 125 220 disulf C-x*-C
DISULFID 159 217 disulf C-x*-C
DISULFID 171 177 disulf C-x*-C

Additional information [?]

Size range 220-230 amino acids
Related rules None
Fusion None
Repeats 1
Topology Not cytoplasmic


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UniProtKB rule member sequences [?]