We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00740
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00740
General rule information
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| Accession | PRU00740 |
| Dates | 25-NOV-2008 (Created)
30-SEP-2022 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51407; LAMP_3 |
Name | Lysosome-associated membrane glycoprotein (lamp) family |
| Function | Lysosome-associated membrane glycoproteins (lamp) are integral membrane proteins, specific to lysosomes. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | P13473; Q7TST5; Q11117; |
Propagated annotation
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Comments
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| case <OC:Chordata> | |
| SUBCELLULAR LOCATION | Lysosome membrane; Single-pass type I membrane protein. |
| else | |
| SUBCELLULAR LOCATION | Membrane; Single-pass type I membrane protein. |
| end case | |
| SIMILARITY | Belongs to the LAMP family. |
Keywords
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| case <OC:Chordata> | |
| Lysosome | |
| end case | |
| Membrane | |
| Transmembrane | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| case <OCellular component:Chordata> | |
| GO:0005764; Cellular component:lysosome | |
| GO:0005765; Cellular component:lysosomal membrane | |
| end case | |
| GO:0016020; Cellular component:membrane | |
Cross-references
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| General | Transmembrane; -; 1; |
| PROSITE | PS00310; LAMP_1; 1; |
| PROSITE | PS00311; LAMP_2; 1; |
Features
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| From: PS51407 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <Feature:PS51407:374=K> | ||||||||||||
| TRANSMEM | 352 | 373 | /note="Helical" | |||||||||
| TOPO_DOM | 374 | 387 | /note="Cytoplasmic" | |||||||||
| else | ||||||||||||
| TRANSMEM | 352 | 376 | /note="Helical" | |||||||||
| TOPO_DOM | 377 | 387 | /note="Cytoplasmic" | |||||||||
| end case | ||||||||||||
| DISULFID | 11 | 50 | disulf | C-x*-C | ||||||||
| DISULFID | 124 | 160 | disulf | C-x*-C | ||||||||
| DISULFID | 202 | 240 | disulf | C-x*-C | ||||||||
| DISULFID | 308 | 345 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 230-410 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [18] All [ 18 ]
- Retrieve set of proteins with 3D structure for this domain