ProRule PRU00740

General rule information [?]

Accession PRU00740
Dates 25-NOV-2008 (Created)
30-SEP-2022 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51407; LAMP_3
Name Lysosome-associated membrane glycoprotein (lamp) family
Function Lysosome-associated membrane glycoproteins (lamp) are integral membrane proteins, specific to lysosomes.
Scope(s) Eukaryota
Example(s) P13473 (LAMP2_HUMAN); Q7TST5 (LAMP3_MOUSE); Q11117 (LMP1_CAEEL);

Propagated annotation [?]

Comments [?]

case <OC:Chordata>
SUBCELLULAR LOCATIONLysosome membrane; Single-pass type I membrane protein.
SUBCELLULAR LOCATIONMembrane; Single-pass type I membrane protein.
end case
SIMILARITYBelongs to the LAMP family.

Keywords [?]

case <OC:Chordata>
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

case <OCellular component:Chordata>
GO:0005764; Cellular component:lysosome
GO:0005765; Cellular component:lysosomal membrane
end case
GO:0016020; Cellular component:membrane

Cross-references [?]

General Transmembrane; -; 1;
PROSITE PS00310; LAMP_1; 1;
PROSITE PS00311; LAMP_2; 1;

Features [?]

From: PS51407
Key From To Description Tag Condition FTGroup
case <Feature:PS51407:374=K>
TRANSMEM 352 373 /note="Helical"
TOPO_DOM 374 387 /note="Cytoplasmic"
TRANSMEM 352 376 /note="Helical"
TOPO_DOM 377 387 /note="Cytoplasmic"
end case
DISULFID 11 50 disulf C-x*-C
DISULFID 124 160 disulf C-x*-C
DISULFID 202 240 disulf C-x*-C
DISULFID 308 345 disulf C-x*-C

Additional information [?]

Size range 230-410 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]