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annotation rule: PRU00740

General rule information [?]

Accession PRU00740
Dates 25-NOV-2008 (Created)
21-NOV-2019 (Last updated, Version 7)
Data class Domain
Predictors PROSITE; PS51407; LAMP_3
Names Lysosome-associated membrane glycoprotein (lamp) family; LAMP family
Function Lysosome-associated membrane glycoproteins (lamp) are integral membrane proteins, specific to lysosomes.

Propagated annotation [?]

Comments [?]

case <OC:Chordata>
Subcellular location Lysosome membrane; Single-pass type I membrane protein.
Subcellular location Membrane; Single-pass type I membrane protein.
end case

Similarity Belongs to the LAMP family.

Computed features [?]

General Transmembrane; -; 1;

Cross-references [?]

case <Feature:PS51407:11=C>
PROSITE PS00310; LAMP_1; 1;
end case

case <Feature:PS51407:345=C>
PROSITE PS00311; LAMP_2; 1;
end case

Gene Ontology [?]

case <OC:Chordata>
GO:0005764; Cellular component: lysosome.
GO:0005765; Cellular component: lysosomal membrane.
end case

GO:0016020; Cellular component: membrane.
GO:0016021; Cellular component: integral component of membrane.

Keywords [?]

case <OC:Chordata>
end case

case <FTTag:disulf>
end case

Features [?]

case <Feature:PS51407:374=K>
From: PS51407
Key     From     To       Description   Tag   Condition   FTGroup
TRANSMEM     352     373       Helical        
TOPO_DOM     374     387       Cytoplasmic        
TRANSMEM     352     376       Helical        
TOPO_DOM     377     387       Cytoplasmic        
end case

DISULFID     11     50           disulf   C-x*-C  
DISULFID     124     160           disulf   C-x*-C  
DISULFID     202     240           disulf   C-x*-C  
DISULFID     308     345           disulf   C-x*-C  

Additional information [?]

Size range 230-410 amino acids
Related rules None
Repeats 1
Topology Undefined
Examples P13473 (LAMP2_HUMAN); Q7TST5 (LAMP3_MOUSE); Q11117 (LMP1_CAEEL): [Recover all]
Eukaryota; Metazoa


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UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Eukaryota [18]