We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00745
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00745
General rule information
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| Accession | PRU00745 |
| Dates | 28-NOV-2008 (Created)
21-NOV-2019 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51412; MACPF_2 |
Name | Membrane attack complex/perforin (MACPF) domain |
| Function | The MACPF domain oligomerizes, undergoes conformational change, and is required for lytic activity. |
| Scope(s) |
Eukaryota Bacteria |
| Example(s) | Q29RU4; |
Propagated annotation
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Cross-references
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| PROSITE | PS00279; MACPF_1; 1; |
Features
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| From: PS51412 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="MACPF #" | |||||||||
Additional information
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| Size range | 315-385 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Not cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [58] All [ 58 ]
- Retrieve set of proteins with 3D structure for this domain