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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00746


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00746
General rule information [?]

Accession PRU00746
Dates 12-DEC-2008 (Created)
13-FEB-2023 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS51413; DBINO
Name DBINO domain
Function The DBINO (DNA binding domain of INO80) domain is characteristic of the INO80 subfamily and is predicted to have DNA-binding function.
Scope(s) Eukaryota
Example(s) O14148;

Propagated annotation [?]

Comments [?]

FUNCTIONATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
SUBUNITComponent of the INO80 chromatin-remodeling complex.
SUBCELLULAR LOCATIONNucleus.

Keywords [?]

Activator
DNA damage
DNA repair
DNA-binding
Nucleus
Transcription
Transcription regulation

Gene Ontology [?]

GO:0006325; Biological process:chromatin organization
GO:0006974; Biological process:DNA damage response
GO:0006281; Biological process:DNA repair
GO:0003677; Molecular function:DNA binding
GO:0005634; Cellular component:nucleus
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Features [?]

From: PS51413
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="DBINO #"

Additional information [?]

Size range 125-135 amino acids
Related rules None
Fusion None
Repeats 1
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]