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annotation rule: PRU00748

General rule information [?]

Accession PRU00748
Dates 3-MAR-2009 (Created)
21-NOV-2019 (Last updated, Version 8)
Data class Domain
Name Xylose isomerase family
Function Xylose isomerase (EC is an enzyme found in microorganisms and plants which catalyzes the interconversion of the aldo sugars D-xylose or D-glucose to the keto sugars D-xylulose and D-fructose. The catalytic activity requires magnesium, cobalt or manganese.

Propagated annotation [?]

Description [?]

case <FT:1>
AltName: Full=Xylose isomerase; EC;

Comments [?]

Catalytic activity RHEA:22816: D-xylose = D-xylulose
end case

case not <OC:Viridiplantae>
Cofactor Mg(2+)
Note: Binds 2 magnesium ions per subunit.
else case <OC:Viridiplantae>
Cofactor Mn(2+)
Note: Binds 2 manganese ions per subunit.
end case

Subunit Homotetramer.
case <OC:Bacteria>
Subcellular location Cytoplasm.
end case

Similarity Belongs to the xylose isomerase family.

Gene Ontology [?]

GO:0009045; Molecular function: xylose isomerase activity.
GO:0042732; Biological process: D-xylose metabolic process.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0016853; Molecular function: isomerase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0046872; Molecular function: metal ion binding.
GO:0006098; Biological process: pentose-phosphate shunt.
case <OC:Viridiplantae>
GO:0030145; Molecular function: manganese ion binding.
end case

case <OC:Bacteria>
GO:0005737; Cellular component: cytoplasm.
end case

Keywords [?]

case <OC:Viridiplantae>
end case

case <OC:Bacteria>
end case

Features [?]

From: PS51415
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     66     66             H  
case not <OC:Viridiplantae>
METAL     197     197       Magnesium 1     E  
METAL     233     233       Magnesium 1     E  
METAL     233     233       Magnesium 2     E  
METAL     236     236       Magnesium 2     H  
METAL     261     261       Magnesium 1     D  
METAL     272     272       Magnesium 2     D  
METAL     274     274       Magnesium 2     D  
METAL     304     304       Magnesium 1     D  
else case <OC:Viridiplantae>
METAL     197     197       Manganese 1     E  
METAL     233     233       Manganese 1     E  
METAL     233     233       Manganese 2     E  
METAL     236     236       Manganese 2     H  
METAL     261     261       Manganese 1     D  
METAL     272     272       Manganese 2     D  
METAL     274     274       Manganese 2     D  
METAL     304     304       Manganese 1     D  
end case

Additional information [?]

Size range 370-420 amino acids
Related rules None
Repeats 1
Topology Undefined
Examples Q93RJ9 (XYLA_STROI); Q9FKK7 (XYLA_ARATH): [Recover all]


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UniProtKB rule member sequences [?]