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annotation rule: PRU00748

General rule information [?]

Accession PRU00748
Dates 3-MAR-2009 (Created)
21-NOV-2019 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS51415; XYLOSE_ISOMERASE
Name Xylose isomerase family
Function Xylose isomerase (EC 5.3.1.5) is an enzyme found in microorganisms and plants which catalyzes the interconversion of the aldo sugars D-xylose or D-glucose to the keto sugars D-xylulose and D-fructose. The catalytic activity requires magnesium, cobalt or manganese.

Propagated annotation [?]


Description [?]

case <FT:1>
AltName: Full=Xylose isomerase; EC 5.3.1.5;

Comments [?]

Catalytic activity RHEA:22816: D-xylose = D-xylulose
EC 5.3.1.5
end case

case not <OC:Viridiplantae>
Cofactor Mg(2+)
Note: Binds 2 magnesium ions per subunit.
else case <OC:Viridiplantae>
Cofactor Mn(2+)
Note: Binds 2 manganese ions per subunit.
end case

Subunit Homotetramer.
case <OC:Bacteria>
Subcellular location Cytoplasm.
end case

Similarity Belongs to the xylose isomerase family.

Gene Ontology [?]

GO:0009045; Molecular function: xylose isomerase activity.
GO:0042732; Biological process: D-xylose metabolic process.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0016853; Molecular function: isomerase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0046872; Molecular function: metal ion binding.
GO:0006098; Biological process: pentose-phosphate shunt.
case <OC:Viridiplantae>
GO:0030145; Molecular function: manganese ion binding.
end case

case <OC:Bacteria>
GO:0005737; Cellular component: cytoplasm.
end case


Keywords [?]

Carbohydrate metabolism
Isomerase
Magnesium
Metal-binding
Pentose shunt
Xylose metabolism
case <OC:Viridiplantae>
Manganese
end case

case <OC:Bacteria>
Cytoplasm
end case


Features [?]

From: PS51415
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     66     66             H  
case not <OC:Viridiplantae>
METAL     197     197       Magnesium 1     E  
METAL     233     233       Magnesium 1     E  
METAL     233     233       Magnesium 2     E  
METAL     236     236       Magnesium 2     H  
METAL     261     261       Magnesium 1     D  
METAL     272     272       Magnesium 2     D  
METAL     274     274       Magnesium 2     D  
METAL     304     304       Magnesium 1     D  
else case <OC:Viridiplantae>
METAL     197     197       Manganese 1     E  
METAL     233     233       Manganese 1     E  
METAL     233     233       Manganese 2     E  
METAL     236     236       Manganese 2     H  
METAL     261     261       Manganese 1     D  
METAL     272     272       Manganese 2     D  
METAL     274     274       Manganese 2     D  
METAL     304     304       Manganese 1     D  
end case


Additional information [?]

Size range 370-420 amino acids
Related rules None
Repeats 1
Topology Undefined
Examples Q93RJ9 (XYLA_STROI); Q9FKK7 (XYLA_ARATH): [Recover all]
Scope
Eukaryota
Bacteria

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]