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ProRule PRU00748


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PURL: https://purl.expasy.org/prosite/rule/PRU00748
General rule information [?]

Accession PRU00748
Dates 03-MAR-2009 (Created)
19-NOV-2022 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS51415; XYLOSE_ISOMERASE
Name Xylose isomerase family
Function Xylose isomerase (EC 5.3.1.5) is an enzyme found in microorganisms and plants which catalyzes the interconversion of the aldo sugars D-xylose or D-glucose to the keto sugars D-xylulose and D-fructose. The catalytic activity requires magnesium, cobalt or manganese.
Scope(s) Eukaryota
Bacteria
Example(s) Q93RJ9; Q9FKK7;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FT:1>
Protein name AltName: Full=Xylose isomerase;
                 EC=5.3.1.5;

Comments [?]

CATALYTIC ACTIVITY Reaction=alpha-D-xylose = alpha-D-xylulofuranose; Xref=Rhea:RHEA:22816, ChEBI:CHEBI:28518, ChEBI:CHEBI:188998; EC=5.3.1.5;
end case
case not <OC:Viridiplantae>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
else case <OC:Viridiplantae>
COFACTOR Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 manganese ions per subunit.;
end case
SUBUNITHomotetramer.
case <OC:Bacteria>
SUBCELLULAR LOCATIONCytoplasm.
end case
SIMILARITYBelongs to the xylose isomerase family.

Keywords [?]

Carbohydrate metabolism
Isomerase
Magnesium
Metal-binding
Pentose shunt
Xylose metabolism
case <OC:Viridiplantae>
Manganese
end case
case <OC:Bacteria>
Cytoplasm
end case

Gene Ontology [?]

GO:0009045; Molecular function:xylose isomerase activity
GO:0042732; Biological process:D-xylose metabolic process
GO:0005975; Biological process:carbohydrate metabolic process
GO:0016853; Molecular function:isomerase activity
GO:0000287; Molecular function:magnesium ion binding
GO:0046872; Molecular function:metal ion binding
GO:0006098; Biological process:pentose-phosphate shunt
case <OCellular component:Viridiplantae>
GO:0030145; Molecular function:manganese ion binding
end case
case <OCellular component:Bacteria>
GO:0005737; Cellular component:cytoplasm
end case

Features [?]

From: PS51415
Key From To Description Tag Condition FTGroup
ACT_SITE 66 66 H
case not <OC:Viridiplantae>
BINDING 197 197 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"		 E
BINDING 233 233 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"		 E
BINDING 233 233 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"		 E
BINDING 236 236 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"		 H
BINDING 261 261 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"		 D
BINDING 272 272 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"		 D
BINDING 274 274 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"		 D
BINDING 304 304 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"		 D
else case <OC:Viridiplantae>
BINDING 197 197 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="1"		 E
BINDING 233 233 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="1"		 E
BINDING 233 233 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="2"		 E
BINDING 236 236 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="2"		 H
BINDING 261 261 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="1"		 D
BINDING 272 272 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="2"		 D
BINDING 274 274 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="2"		 D
BINDING 304 304 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="1"		 D
end case

Additional information [?]

Size range 370-420 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]